Keur van grafsteenen op de Nederl.-Portug.-Israe͏̈l. begraafplaats te Ouderkerk aan den Amstel met beschrijving en biographische aanteekeningen : tot inleiding een en ander over deze en de vroegere begraafplaats der Nederl.-Portug.-Israe͏̈l. gemeente te Amsterdam ; eerste bundel

von D. Henriques de Castro

Chronologisch handboekje voor de geschiedenis der Israeliten van de schepping der wereld tot op onzen tijd

uit de deloofwaardigste bronnen bearb. door S. I. Mulder

Dr. Samson Philip Nathan : ein Lebens- u. Charakterbild

von Salomon Goldschmidt

De beide oudste hebreeuwsche bijbeluitgaven van Amsterdam

[Jac. Zwarts]

Šeërith Jisrael : of Lotgevallen der Joden in alle werelddeelen, van af de verwoesting des 2. tempels tot het jaar 1770

door Menachem Man ben Salomo Halevi... uit het Joodsch-Duitsch vertaald door L. Goudsmit ... verrijkt door G. I. Polak

Catalogus der tentoonstelling in het Portugeesch Israelietisch Seminarium "Ets Haim" te Amsterdam : ter herinnering aan het driehonderd-jarig jubileum van het eerste door Menassah Ben Israel te Amsterdam gedrukte Hebreeuuwsche boek

samengesteld da J. S. Da Silva Rosa

Ellis-van Creveld Syndrome in Grey Alpine Cattle: Morphologic, Immunophenotypic, and Molecular Characterization

Ellis-van Creveld (EvC) syndrome is a human autosomal recessive disorder caused by a mutation in either the EVC or EVC2 gene, and presents with short limbs, polydactyly, and ectodermal and heart defects. The aim of this study was to understand the pathologic basis by which deletions in the EVC2 gene lead to chondrodysplastic dwarfism and to describe the morphologic, immunohistochemical, and molecular hallmarks of EvC syndrome in cattle. Five Grey Alpine calves, with a known mutation in the EVC2 gene, were autopsied. Immunohistochemistry was performed on bone using antibodies to collagen II, collagen X, sonic hedgehog, fibroblast growth factor 2, and Ki67. Reverse transcription polymerase chain reaction was performed to analyze EVC1 and EVC2 gene expression. Autopsy revealed long bones that were severely reduced in length, as well as genital and heart defects. Collagen II was detected in control calves in the resting, proliferative, and hypertrophic zones and in the primary and secondary spongiosa, with a loss of labeling in the resting zone of 2 dwarfs. Collagen X was expressed in hypertrophic zone in the controls but was absent in the EvC cases. In affected calves and controls, sonic hedgehog labeled hypertrophic chondrocytes and primary and secondary spongiosa similarly. FGF2 was expressed in chondrocytes of all growth plate zones in the control calves but was lost in most EvC cases. The Ki67 index was lower in cases compared with controls. EVC and EVC2 transcripts were detected. Our data suggest that EvC syndrome of Grey Alpine cattle is a disorder of chondrocyte differentiation, with accelerated differentiation and premature hypertrophy of chondrocytes, and could be a spontaneous model for the equivalent human disease.