Songs for soprano, alto, tenor and bass: Op. 41, 48, 59, 88, 100.

Mode of access: Internet.

Die englischen Marineausgaben und deren Deckung seit 1887-88.

Thesis (doctoral)--Ludwig-Maximilians-Universitat Munchen.

Proposed Gulf of Alaska/Cook Inlet lease sale 88 : final environmental impact statement /

Item 603-G

Galleria biografica della Nuova rivista degli scacchi : (estratti dalle annate 1885-86-87-88).

"Ritratti e biografie di G.M. Borgi, G. Moreno, G.B. Maluta, C.B. Vansittart, L. Sprega, V. Salimbeni."

Fragm. lat. II 88 - Breviarium (Sonn- und Ferialtage nach Pfingsten)

Trägerbände: Inc. qu. 781; Inc. qu. 1106; Inc. oct. 387; Inc. oct. 395; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Fragm. lat. I 80 - Psalterium (Ps 67,31 - 36; 68,1 - 4; 73,10 - 23; 88,8 - 25)

Trägerband: Inc. fol. 237; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Fragm. lat. I 88 - Missale (Sabb. a.Dom.passionis; Dom.; Fer.III p.Dom.passionis)

Trägerband: Inc. qu. 1011

Handbüchlein zur angenehmen und nützlichen Beschäftigung für junge Damen, oder Encyclopädie der vorzüglichsten weiblichen Kunstarbeiten, namentlich des Zuschneidens und Nähens der Wäsche ... ; mit 88 Abbildungen

von Charlotte L***

Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88)

The phosphosulfomannan 1 (PI-88) is a mixture of highly sulfated oligosaccharides that is currently undergoing clinical evaluation in cancer patients. As well as it's anticancer properties, 1 displays a number of other interesting biological activities. A series of analogues of 1 were synthesized with a single carbon (pentasaccharide) backbone to facilitate structural characterization and interpretation of biological results. In a fashion similar to 1, all compounds were able to inhibit heparanase and to bind tightly to the proangiogenic growth factors FGF-1, FGF-2, and VEGF. The compounds also inhibited the infection of cells and cell-to-cell spread of herpes simplex virus (HSV-1). Preliminary pharmacokinetic data indicated that the compounds displayed different pharmacokinetic behavior compared with 1. Of particular note was the n-octyl derivative, which was cleared 3 times less rapidly than 1 and may provide increased systemic exposure.