Crystal structures of isotypic poly[bis(benzimidazolium) [tetra-μ-iodido-stannate(II)]] and poly[bis(5,6-difluorobenzimidazolium) [tetra-μ-iodido-stannate(II)]]

The isostructural title compounds, {(C7H7N2)2[SnI4]}n, (1), and {(C7H5F2N2)2[SnI4]}n, (2), show a layered perovskite-type structure composed of anionic {[SnI4]2-}n sheets parallel to (100), which are decorated on both sides with templating benzimidazolium or 5,6-di­fluoro­benzimidazolium cations, respectively. These planar organic heterocycles mainly form N-H...I hydrogen bonds to the terminal I atoms of the corner-sharing [SnI6] octa­hedra (point group symmetry 2) from the inorganic layer, but not to the bridging ones. This is in contrast to most of the reported structures of related compounds where ammonium cations are involved. Here hydrogen bonding to both types of iodine atoms and thereby a distortion of the inorganic layers to various extents is observed. For (1) and (2), all Sn-I-Sn angles are linear and no out-of-plane distortions of the inorganic layers occur, a fact of relevance in view of the material properties. The arrangement of the aromatic cations is mainly determined through the direction of the N-H...I hydrogen bonds. The coherence between organic bilayers along [100] is mainly achieved through van der Waals inter­actions.

Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer

The gastrin-releasing peptide receptor (GRPr) is an important molecular target for the visualization and therapy of tumors and can be targeted with radiolabeled bombesin derivatives. The present study aims to develop statine-based bombesin receptor antagonists suitable for labeling with 64Cu for imaging by positron emission tomography (PET). The potent GRPr antagonist D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 was conjugated to the sarcophagine (3,6,10,13,16,19-hexaazabicyclo[6.6.6] icosane=Sar) derivative 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid (MeCOSar) via PEG4 (LE1) and PEG2 (LE2) spacers and radiolabeled with 64Cu2+ with >95% yield and specific activities of about 100 MBq/nmol. Both Cu(II) conjugates have high affinity for GRPr (IC50: natCu-LE1, 1.4±0.1 nM; natCu-LE2, 3.8±0.6 nM). The antagonistic properties of both conjugates were confirmed by Ca2+-flux measurements. Biodistribution studies of Cu-64-LE1 exhibited specific targeting of the tumor (19.6±4.7% IA/g at 1 h p.i.) and GRPr-positive organs. Biodistribution and PET images at 4 and 24 h postinjection showed increasing tumor-to-background ratios with time. This was illustrated by the acquisition of PET images showing high tumor-to-normal tissue contrast. This study demonstrates the high affinity of the MeCOSar-PEGx-bombesin conjugates to GRPr. The stability of 64Cu complexes of MeCOSar, the long half-life of 64Cu, and the suitable biodistribution profile of the 64Cu-labeled peptides lead to PET images of high contrast suitable for potential translation into the clinic.

Na 1 Nachlass Max Horkheimer, 69 - Korrespondenzen u..a mit Lilly Eckmeyer (p. II 6, 1-91)

5 Briefe zwischen C. C. Eckhardt und Max Horkheimer, 1942; 41 Briefe und Beilage zwischen Lilly Eckmeyer und Max Horkheimer, 1947-1950; 1 Brief und Beilage von Max Horkheimer an das Colegio de Mexico, 1943; 15 Briefe zwischen K. Heiner Emhardt und Max Horkheimer, 1945-1948; 8 Briefe und Beilage zwischen Ernst Engelberg und Max Horkheimer, 1946-1947; 5 Briefe zwischen Gertrude Speer und Max Horkheimer, 1946 siehe auch Ernst Engelberg; 1 Brief von Max Horkheimer an Erik H. Erikson, 1946; 2 Briefe und Beilage zwischen Esprit [Zeitschrift] und Max Horkheimer, 1947, 1948;

Vorstellung der scharpffen Execution, wie selbige an 6 Malefitz Personen in der Fürstlichen Statt Wohlau, den 27. April, vnd II July deß 1661. Jahrs, vollzogen worden : Von ihrem abscheulichen Verbrechen, meldet der Text weitläufftig

Original: Text fehlt. Risse u. kleinere Fehlstellen im Kupferstich

Der fliegende Holländer (II. 6.)

Signatur des Originals: S 36/F07552

Fragm. lat. I 100 - De consolatione philosophiae (II 8,6 - III 1,3; III 6,5 - 8,3), mit Rand- und Interlinearglossen

Trägerband: Ms. Praed. 109; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Fragm. lat. II 6 - Ordo iudiciarius. Versus de arboribus, volucribus, piscibus et herbis, mit deutschen Interlinearglossen

Trägerbände: Ms. Barth. 26; Ms. Barth. 29; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

II Jornadas Internacionales y III Nacionales de Estudios Clásicos Ordia Prima: Sexo, cuerpo y género y saber en la antigüedad grecolatina : Córdoba, Universidad Nacional de Córdoba, 6, 7 y 8 de agosto de 2009

Fil: Pedernera, Soledad. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

II Jornadas Internacionales y III Nacionales de Estudios Clásicos Ordia Prima: Sexo, cuerpo y género y saber en la antigüedad grecolatina : Córdoba, Universidad Nacional de Córdoba, 6, 7 y 8 de agosto de 2009

Fil: Pedernera, Soledad. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.