Isolation and structural determination of non-racemic tertiary cathinone derivatives

The racemic tertiary cathinones N,N-dimethylcathinone (1), N,N-diethylcathinone (2) and 2-(1-pyrrolidinyl)-propiophenone (3) have been prepared in reasonable yield and characterized using NMR and mass spectroscopy. HPLC indicates that these compounds are isolated as the anticipated racemic mixture. These can then be co-crystallized with (+)-O,O′-di-p-toluoyl-d-tartaric, (+)-O,O′-dibenzoyl-d-tartaric and (-)-O,O′-dibenzoyl-l-tartaric acids giving the single enantiomers S and R respectively of 1, 2 and 3, in the presence of sodium hydroxide through a dynamic kinetic resolution. X-ray structural determination confirmed the enantioselectivity. The free amines could be obtained following basification and extraction. In methanol these are reasonably stable for the period of several hours, and their identity was confirmed by HPLC and CD spectroscopy.

Swellable polymer films containing Au nanoparticles for point-of-care therapeutic drug monitoring using surface-enhanced Raman spectroscopy

Large (10 × 10 cm) sheets of surface-enhanced Raman spectroscopy (SERS) active polymer have been prepared by stabilising metal nanoparticle aggregates within dry hydroxyethylcellulose (HEC) films. In these films the aggregates are protected by the polymer matrix during storage but in use they are released when aqueous analyte droplets cause the films to swell to their gel form. The fact that these "Poly-SERS" films can be prepared in bulk but then cut to size and stored in air before use means that they provide a cost effective and convenient method for routine SERS analysis. Here we have tested both Ag and Au Poly-SERS films for use in point-of-care monitoring of therapeutic drugs, using phenytoin as the test compound. Phenytoin in water could readily be detected using Ag Poly-SERS films but dissolving the compound in phosphate buffered saline (PBS) to mimic body fluid samples caused loss of the drug signal due to competition for metal surface sites from Cl^- ions in the buffer solution. However, with Au Poly-SERS films there was no detectable interference from Cl^- and these materials allowed phenytoin to be detected at 1.8 mg L^-1, even in PBS. The target range of detection of phenytoin in therapeutic drug monitoring is 10-20 mg L^-1. With the Au Poly-SERS films, the absolute signal generated by a given concentration of phenytoin was lower for the films than for the parent colloid but the SERS signals were still high enough to be used for therapeutic monitoring, so the cost in sensitivity for moving from simple aqueous colloids to films is not so large that it outweighs the advantages which the films bring for practical applications, in particular their ease of use and long shelf life.

Gender mismatch between donor and recipient is a factor of morbidity but does not condition survival after cardiac transplantation

We intended to evaluate the influence of sex mismatch between donor and recipient, which is still under much debate, on survival and comorbidities after cardiac transplantation. From November 2003 to December 2013, a total of 258 patients were transplanted in our center. From these, 200 receptors were male (77.5%) and constituted our study population, further divided into those who received the heart from a female donor (Group A) - 44 patients (22%) and those who received it from a male donor (Group B) - 156 (78%). Median follow-up was 4.2 ± 3.0 years (1-10 years). The two groups were quite comparable with each other, except for body mass index, systolic pulmonary artery pressure, and transpulmonary gradient, which were significantly lower in Group A. A low donor/recipient weigh ratio (<0.8) was avoided whenever possible. Hospital mortality was not different in the two groups. During follow-up, global survival was similar, as was survival free from acute cellular rejection and cardiac allograft vasculopathy. However, patients in Group A had decreased survival free from serious infections and malignant tumors. Allocation of female donors to male receptors can be done safely, at least in receptors without pulmonary hypertension and when an adequate donor/recipient weigh ratio is ensured.

“Digital Diagnostics and Communication (DDC) system” Redesigning the Emergency Ambulance

During the development of a new treatment space for the UK emergency ambulance participatory observations with front-line clinicians revealed the need for an integrated patient monitoring, communication and navigation system. The research identified the different information touch-points and requirements through modes of use analysis, day-in-the-life study and simulation workshops with clinicians. Emergency scenario and role-play with paramedics identified 5 distinct ambulance modes of use. Information flow diagrams were created and checked by paramedics and digital User Interface (UI) wireframes were developed and evaluated by clinicians during clinical evaluations. Feedback from clinicians defined UI design specification further leading to a final design proposal. This research was a further development from the 2007 EPSRC funded “Smart Pods” project. The resulting interactive prototype was co-designed in collaboration with ambulance crews and provides a vision of what could be achieved by integrating well-proven IT technologies and protocols into a package relevant in the emergency medicine field. The system has been reviewed by over 40 ambulance crews and is part of a newly co-designed ambulance treatment space.

Gender mismatch between donor and recipient is a factor of morbidity but does not condition survival after cardiac transplantation

We intended to evaluate the influence of sex mismatch between donor and recipient, which is still under much debate, on survival and comorbidities after cardiac transplantation. From November 2003 to December 2013, a total of 258 patients were transplanted in our center. From these, 200 receptors were male (77.5%) and constituted our study population, further divided into those who received the heart from a female donor (Group A) - 44 patients (22%) and those who received it from a male donor (Group B) - 156 (78%). Median follow-up was 4.2 ± 3.0 years (1-10 years). The two groups were quite comparable with each other, except for body mass index, systolic pulmonary artery pressure, and transpulmonary gradient, which were significantly lower in Group A. A low donor/recipient weigh ratio (<0.8) was avoided whenever possible. Hospital mortality was not different in the two groups. During follow-up, global survival was similar, as was survival free from acute cellular rejection and cardiac allograft vasculopathy. However, patients in Group A had decreased survival free from serious infections and malignant tumors. Allocation of female donors to male receptors can be done safely, at least in receptors without pulmonary hypertension and when an adequate donor/recipient weigh ratio is ensured.

Professor em formação em busca da excelência na sua prática

Relatório de estágio apresentado à Escola Superior de Educação de Paula Frassinetti, para obtenção do grau de mestre em Ensino do 1º e 2º ciclos do ensino básico

Relaciones entre conducta agresiva y metas académicas: estudio con una muestra de estudiantes españoles de Educación Secundaria Obligatoria

Este estudio analizó la relación entre la conducta agresiva y las metas académicas en una muestra de 2.022 estudiantes españoles de Educación Secundaria Obligatoria (ESO ). La conducta agresiva fue evaluada con el Teenage Inventory of Social Skills (TISS) y las metas académicas mediante el Achievement Goal Tendencies Questionnaire (AGTQ). Los resultados revelaron que los estudiantes con alta conducta agresiva, de ambos sexos y de todos los cursos académicos de ESO , presentaron puntuaciones significativamente más altas en metas de reforzamiento social que sus iguales con baja conducta agresiva. Los análisis de regresión logística mostraron que la conducta agresiva fue un predictor positivo y estadísticamente significativo de las metas de reforzamiento social en ambos sexos y en todos los cursos de ESO.

Um olhar sobre o castelo de Noudar: do castelo medieval à ruína: Proposta de valorização do lugar

O Castelo de Noudar está implantado num íngreme promontório da herdade da Coitadinha, a Noroeste de Barrancos, integrando o atual Parque da Natureza de Noudar. Construído a partir de 1303, foi alvo de diversas transformações ao longo do tempo, para responder às exigências militares de cada época, e chega aos nossos dias num avançado estado de decadência física. A investigação desenvolvida assenta, em grande parte, no desenho: de Noudar a uma escala territorial, como elemento que participa numa rede fortificada complexa; da evolução morfológica e funcional, que nos permite ter noção das várias configurações do castelo ao longo dos séculos; num desenho propositivo que desenvolve uma estratégia para valorização do lugar e do seu património material e imaterial. Hoje é fundamental compreender como as valências do Parque e da fortaleza se podem cruzar? Este trabalho pretende refletir sobre possibilidades de valorização para contrariar a degradação em que a fortaleza se encontra; ABSTRACT: The Noudar Castle is located in a steep promontory in the herdade da Coitadinha, Northeast from Barrancos, part of the Natural Park of Noudar. Its construction began in 1303, and underwent several transformations throughout its existence, adapting to the military advancements thru out the ages. Today, it shows an advanced state of decay. The investigation is focused on the design of Noudar on a territorial scale, taking part in a complex network of fortified systems; its functional and morphological evolution, which allows us to comprehend the configurations of the castle throughout the centuries; and on a proposed design that develops a strategy to enhance and bring value to this place and its material and non-material heritage. Today it's crucial to comprehend how can the values of the Park and fortress intertwine. This thesis reflects on the possibilities of valuing this site, counter acting the decay which has fallen upon it.

PPARα regulates endothelial progenitor cell maturation and myeloid lineage differentiation through a NADPH oxidase-dependent mechanism in mice

International audience

Compounds, creativity and complexity in climate change communication: the case of ‘carbon indulgences’

This article deals with climate change from a linguistic perspective. Climate change is an extremely complex issue that has exercised the minds of experts and policy makers with renewed urgency in recent years. It has prompted an explosion of writing in the media, on the internet and in the domain of popular science and literature, as well as a proliferation of new compounds around the word ‘carbon’ as a hub, such as ‘carbon indulgence’, a new compound that will be studied in this article. Through a linguistic analysis of lexical and discourse formations around such ‘carbon compounds’ we aim to contribute to a broader understanding of the meaning of climate change. Lexical carbon compounds are used here as indicators for observing how human symbolic cultures change and adapt in response to environmental threats and how symbolic innovation and transmission occurs.

Los saberes profesionales docentes en la enseñanza de prácticas investigativas en escuelas secundarias : Una primera aproximación

La presente Tesina de Licenciatura se propusoanalizar y caracterizar los saberes profesionales docentes que intervienen en la enseñanza de prácticas investigativas, en escuelas secundarias de la Provincia de Buenos Aires, específicamente en el espacio curricular Proyecto de Investigación en Ciencias Sociales (6o año del ciclo superior de la escuela secundaria). Asimismo, se puso especial foco en la indagación acerca de las propuestas de enseñanza que los docentes desarrollan, sobre qué fundamentos apoyan sus decisiones, qué relaciones establecen con el diseño curricular y qué influencias perciben del contexto institucional en sus propuestas. Se trató de un estudio realizado desde el paradigma hermenéutico. En este marco se realizaron entrevistas semiestructuradas a docentes que se desempeñaban en este espacio curricular. Es decir que el análisis se centró únicamente en el discurso de los/as docentes entrevistados. A partir de dicho análisis, y con base en los estudios sobre saberes y conocimientos docentes, en una primera aproximación, se identificaron y caracterizaron saberes que pusieron en juego los/as docentes en las propuestas que expresaron desarrollar, sus fundamentos y procedencias

Los saberes profesionales docentes en la enseñanza de prácticas investigativas en escuelas secundarias : Una primera aproximación

La presente Tesina de Licenciatura se propusoanalizar y caracterizar los saberes profesionales docentes que intervienen en la enseñanza de prácticas investigativas, en escuelas secundarias de la Provincia de Buenos Aires, específicamente en el espacio curricular Proyecto de Investigación en Ciencias Sociales (6o año del ciclo superior de la escuela secundaria). Asimismo, se puso especial foco en la indagación acerca de las propuestas de enseñanza que los docentes desarrollan, sobre qué fundamentos apoyan sus decisiones, qué relaciones establecen con el diseño curricular y qué influencias perciben del contexto institucional en sus propuestas. Se trató de un estudio realizado desde el paradigma hermenéutico. En este marco se realizaron entrevistas semiestructuradas a docentes que se desempeñaban en este espacio curricular. Es decir que el análisis se centró únicamente en el discurso de los/as docentes entrevistados. A partir de dicho análisis, y con base en los estudios sobre saberes y conocimientos docentes, en una primera aproximación, se identificaron y caracterizaron saberes que pusieron en juego los/as docentes en las propuestas que expresaron desarrollar, sus fundamentos y procedencias

Los saberes profesionales docentes en la enseñanza de prácticas investigativas en escuelas secundarias : Una primera aproximación

La presente Tesina de Licenciatura se propusoanalizar y caracterizar los saberes profesionales docentes que intervienen en la enseñanza de prácticas investigativas, en escuelas secundarias de la Provincia de Buenos Aires, específicamente en el espacio curricular Proyecto de Investigación en Ciencias Sociales (6o año del ciclo superior de la escuela secundaria). Asimismo, se puso especial foco en la indagación acerca de las propuestas de enseñanza que los docentes desarrollan, sobre qué fundamentos apoyan sus decisiones, qué relaciones establecen con el diseño curricular y qué influencias perciben del contexto institucional en sus propuestas. Se trató de un estudio realizado desde el paradigma hermenéutico. En este marco se realizaron entrevistas semiestructuradas a docentes que se desempeñaban en este espacio curricular. Es decir que el análisis se centró únicamente en el discurso de los/as docentes entrevistados. A partir de dicho análisis, y con base en los estudios sobre saberes y conocimientos docentes, en una primera aproximación, se identificaron y caracterizaron saberes que pusieron en juego los/as docentes en las propuestas que expresaron desarrollar, sus fundamentos y procedencias

Lean e sua aplicabilidade na indústria da construção

Nos tempos que correm a gestão de topo das empresas tem como desafio adaptar-se às exigências do mercado, tendo em conta a crise atravessada nos diversos setores. O lean mais do que uma ferramenta, é uma filosofia de vida que visa a excelência. Esta filosofia contém dois pilares importantes, a melhoria contínua e o respeito pelas pessoas. A melhoria contínua pretendida visa a obtenção do valor esperado e definido perante um desafio. O lean é uma filosofia de gestão que nasce após a segunda guerra mundial caracterizado como sistema de produção enxuto que visa eliminação de desperdícios. Algumas empresas do setor da construção após verificar os resultados satisfatórios noutras áreas, impuseram a implementação da filosofia lean nas suas organizações. Esta implementação passa por adotar ferramentas que visam a eliminação de desperdícios, produção puxada e a flexibilidade de processos. A construção adotou ferramentas tais como: just in time, definição de valor, definição de desperdício, fluxo contínuo, task time, sistema puxado, poka-yoke, kanban, heijunka (nivelamento de produção), seis sigmas, last planner, kaizen, fluxo de valor, 5S`s. A presente tese pretende clarificar algumas destas ferramentas e conceitos, aproximando-os da área da construção. Inclui-se um questionário a um grupo de trabalhadores de uma empresa de construção que está na fase inicial de implementação do lean. O questionário visou entender em que fase se encontra a implementação e a importância dada ao tema pelos trabalhadores. Foram analisados alguns casos práticos onde a gestão da empresa decidiu implementar o lean.