Biosusceptometria de corrente alternada para avaliação do trânsito gastrintestinal de alimentos líquidos em ratos

The gastrointestinal tract is the main route of nutrients absorption and drugs delivery. Is important to know the parameters related to the tract, like gastric emptying and gastrointestinal transit, in order to better understand the behavior of different kind of meals or drugs passing through the GIT. Many techniques are used to study these parameters, such as manometry, scintigraphy, phenol red, activated charcoal and carbon-13 reading. However, these methods use radiation, are invasive and require animal sacrifice. As an alternative proposal, the Alternate Current Biosusceptometry (ACB), a magnetic technique, has proved to be effective for these studies with small animals, in a noninvasive way, low cost, radiation free and avoiding the animal death. Associating the ACB to magnetic micro or nanoparticles used as tracers, it is possible to observe the meal behavior inside of the GIT. Focusing meanly on liquid meals digestion, this paper had the objective to evaluate the efficiency of the ACB technique in gastric emptying and gastrointestinal transit evaluation of liquid meals in rats. To perform the experiments, magnetic nanoparticles (ferrite, MgFe2O4) were used on a 1,5 ml solution introduced by gavage on similar weight and age rats. The sensor made by 2 pairs of coils, capable of generating and detecting magnetic fields, creates a field on the interest place and when this field is in contact with the marked meal, it changes, resulting on a variation of the measured voltage. The voltage variation is analyzed and is obtained a particle concentration on the interest region. The results showed that is possible to apply the ACB technique on the GIT evaluation of liquid particles digestion, gastric emptying and meal cecum arrival time curves were obtained and from that, is possible to observe a pattern of gastrointestinal transit. Both mean process time values were acquired, proving the technique capability of ...

Advanced SPM studies on the growth of ultrathin films of organic semiconductors at metal and dielectric interfaces

Many studies on the morphology, molecular orientation, device performance, substrate nature and growth parameter dependence have been carried out since the proposal of Sexithiophene (6T) for organic electronics [ ] However, these studies were mostly performed on films thicker than 20nm and without specifically addressing the relationship between morphology and molecular orientation within the nano and micro structures of ultrathin films of 0-3 monolayers. In 2004, the observation that in OFETs only the first few monolayers at the interface in contact with the gate insulator contribute to the charge transport [ ], underlined the importance to study submonolayer films and their evolution up to a few monolayers of thickness with appropriate experimental techniques. We present here a detailed Non-contact Atomic Force Microscopy and Scanning Tunneling Microscopy study on various substrates aiming at the investigation of growth mechanisms. Most reported similar studies are performed on ideal metals in UHV. However it is important to investigate the details of organic film growth on less ideal and even technological surfaces and device testpatterns. The present work addresses the growth of ultra thin organic films in-situ and quasi real-time by NC-AFM. An organic effusion cell is installed to evaporate the organic material directly onto the SPM sample scanning stage.

COMPUTATIONAL STUDY OF MICROSTRUCTURE-PROPERTYMECHANISM RELATIONS IN FERROIC COMPOSITES

Ferroic materials, as notable members of smart materials, have been widely used in applications that perform sensing, actuation and control. The macroscopic property change of ferroic materials may become remarkably large during ferroic phase transition, leading to the fact that the macroscopic properties can be tuned by carefully applying a suitable external field (electric, magnetic, stress). To obtain an enhancement in physical and/or mechanical properties, different kinds of ferroic composites have been fabricated. The properties of a ferroic composite are determined not only by the properties and relative amounts of the constituent phases, but also by the microstructure of individual phase such as the phase connectivity, phase size, shape and spatial arrangement. This dissertation mainly focuses on the computational study of microstructure – property – mechanism relations in two representative ferroic composites, i.e., two-phase particulate magnetoelectric (ME) composite and polymer matrix ferroelectric composite. The former is a great example of ferroic composite exhibiting a new property and functionality that neither of the constituent phases possesses individually. The latter well represents the kind of ferroic composites having property combinations that are better than the existing materials. Phase field modeling was employed as the computing tool, and the required models for ferroic composites were developed based on existing models for monolithic materials. Extensive computational simulations were performed to investigate the microstructure-property relations and the underlying mechanism in ferroic composites. In particulate, it is found that for ME composite 0-3 connectivity (isolated magnetostrictive phase) is necessary to exhibit ME effect, and small but finite electrical conductivity of isolated magnetic phase can beneficially enhance ME effect. It is revealed that longitudinal and transverse ME coefficients of isotropic 0-3 particulate composites can be effectively tailored by controlling magnetic domain structures without resort to anisotropic two-phase microstructures. Simulations also show that the macroscopic properties of the ferroelectricpolymer composites critically depend on the ferroelectric phase connectivity while are not sensitive to the sizes and internal grain structures of the ceramic particles. Texturing is found critical to exploit the paraelectric«ferroelectric phase transition and nonlinear polarization behavior in paraelectric polycrystal and its polymer matrix composite. Additionally, a Diffuse Interface Field model was developed to simulate packing and motion in liquid phase which is promising for studying the fabrication of particulatepolymer composites.

Rompendo velhas mortalhas: a violência contra a mulher e sua relação com o Imaginário Androcêntrico de Deus na Igreja Metodista do Chile.

A presente tese tem como objetivo abordar e analisar a violência contra a mulher e a relação que existiria entre essa conduta e a imagem androcêntrica de "Deus", em um contexto específico: homens e mulheres da Igreja Metodista no Chile. Fizemos uma leitura analítica da maneira de se relacionar as mulheres e os homens nos matrimônios, e as mulheres e os homens com "Deus". O intuito é explorar as similitudes que existem entre a atitude hierárquica do homem na sociedade e na família e o modelo de "Deus" masculino presente no imaginário coletivo da sociedade. A questão foi desenvolvida tendo como eixo principal a imagem indrocêntrica de "Deus" e as variáveis que desde essa imagem se desprendem, a saber, a construção e a ideologia androcêntrica, a sobrevalorização da hegemonia e a linguagem masculina e a legitimação da violência contra mulher. Esta situação é analisada desde um contexto específico a Igreja Metodista no Chile, mas este fato é apenas o contexto de onde começamos a observar os casos de violência contra a mulher, o que permitiu sair desse contexto restringido, para um contexto mais abrangente. Por conseguinte, na procura de fundamentos para elucidar as hipóteses, levantamos alguns elementos antropológicos herdados das ideologias e crenças dos espanhóis e dos indígenas, os quais foram fundamentais na construção do ethos e da idiossincrasia chilena. Para a análise e a crítica do imaginário masculino de Deus, privilegiamos a produção da teologia feminista e, para o conceito de violência que contem a noção de poder, privilegiamos a concepção de micro-poder, estimando que a violência contra da mulher se concretiza, primordialmente, em nível de micro estruturas, ainda que o fato esteja legitimado em nível de macro estruturas. O objetivo desta tese é contribuir na reflexão teológico-pastoral desde a perspectiva da mulher, visando fornecer elementos de debate no caminho à superação da violência.(AU)

Rompendo velhas mortalhas: a violência contra a mulher e sua relação com o Imaginário Androcêntrico de Deus na Igreja Metodista do Chile.

A presente tese tem como objetivo abordar e analisar a violência contra a mulher e a relação que existiria entre essa conduta e a imagem androcêntrica de "Deus", em um contexto específico: homens e mulheres da Igreja Metodista no Chile. Fizemos uma leitura analítica da maneira de se relacionar as mulheres e os homens nos matrimônios, e as mulheres e os homens com "Deus". O intuito é explorar as similitudes que existem entre a atitude hierárquica do homem na sociedade e na família e o modelo de "Deus" masculino presente no imaginário coletivo da sociedade. A questão foi desenvolvida tendo como eixo principal a imagem indrocêntrica de "Deus" e as variáveis que desde essa imagem se desprendem, a saber, a construção e a ideologia androcêntrica, a sobrevalorização da hegemonia e a linguagem masculina e a legitimação da violência contra mulher. Esta situação é analisada desde um contexto específico a Igreja Metodista no Chile, mas este fato é apenas o contexto de onde começamos a observar os casos de violência contra a mulher, o que permitiu sair desse contexto restringido, para um contexto mais abrangente. Por conseguinte, na procura de fundamentos para elucidar as hipóteses, levantamos alguns elementos antropológicos herdados das ideologias e crenças dos espanhóis e dos indígenas, os quais foram fundamentais na construção do ethos e da idiossincrasia chilena. Para a análise e a crítica do imaginário masculino de Deus, privilegiamos a produção da teologia feminista e, para o conceito de violência que contem a noção de poder, privilegiamos a concepção de micro-poder, estimando que a violência contra da mulher se concretiza, primordialmente, em nível de micro estruturas, ainda que o fato esteja legitimado em nível de macro estruturas. O objetivo desta tese é contribuir na reflexão teológico-pastoral desde a perspectiva da mulher, visando fornecer elementos de debate no caminho à superação da violência.(AU)

Rompendo velhas mortalhas: a violência contra a mulher e sua relação com o Imaginário Androcêntrico de Deus na Igreja Metodista do Chile.

A presente tese tem como objetivo abordar e analisar a violência contra a mulher e a relação que existiria entre essa conduta e a imagem androcêntrica de "Deus", em um contexto específico: homens e mulheres da Igreja Metodista no Chile. Fizemos uma leitura analítica da maneira de se relacionar as mulheres e os homens nos matrimônios, e as mulheres e os homens com "Deus". O intuito é explorar as similitudes que existem entre a atitude hierárquica do homem na sociedade e na família e o modelo de "Deus" masculino presente no imaginário coletivo da sociedade. A questão foi desenvolvida tendo como eixo principal a imagem indrocêntrica de "Deus" e as variáveis que desde essa imagem se desprendem, a saber, a construção e a ideologia androcêntrica, a sobrevalorização da hegemonia e a linguagem masculina e a legitimação da violência contra mulher. Esta situação é analisada desde um contexto específico a Igreja Metodista no Chile, mas este fato é apenas o contexto de onde começamos a observar os casos de violência contra a mulher, o que permitiu sair desse contexto restringido, para um contexto mais abrangente. Por conseguinte, na procura de fundamentos para elucidar as hipóteses, levantamos alguns elementos antropológicos herdados das ideologias e crenças dos espanhóis e dos indígenas, os quais foram fundamentais na construção do ethos e da idiossincrasia chilena. Para a análise e a crítica do imaginário masculino de Deus, privilegiamos a produção da teologia feminista e, para o conceito de violência que contem a noção de poder, privilegiamos a concepção de micro-poder, estimando que a violência contra da mulher se concretiza, primordialmente, em nível de micro estruturas, ainda que o fato esteja legitimado em nível de macro estruturas. O objetivo desta tese é contribuir na reflexão teológico-pastoral desde a perspectiva da mulher, visando fornecer elementos de debate no caminho à superação da violência.(AU)

Microstructures layering, mechanisms in the middle waters of the Persian Gulf

Layered structures, known as micro structures in marine environments are common features of which their formation mechanisms are first reviewed. Some methods of measuring such features based on the measurements and theories are presented for the Persian Gulf. This includes determination of layers with temperature inversion (TI) associated with double diffusive convection (DDC). The relevant associated parameters are estimated from ROPME CTD data for late winter and early summer of 1992. Only in certain parts temperature inversion and DDC are observed which seem to produce layered structures. Observations show that the places with TI and DDC are mainly confined to the frontal regions where the water entering the Persian Gulf and water exiting it meet, nearly along the axis of the Gulf. TI and DDC is mainly observer in the northern bound of the front. Typical density ratio for regions with TI and DDC is 0.7 to 0.2 and the mean depth is at about 37 ± 3 m for the Persian Gulf. TI and DDC are also found in the outflow from the Persian Gulf to the Oman Gulf which is found to be at a depth of about 250 m. Horizontal addiction and reduction of solar heating seem to be the main reasons in producing layers with TI and DDC. It is also found that the regime of DDC in the Persian Gulf is more diffusive and the flow associated with intrusion layers with TI is non-isopycnal (more unstable). However for the Oman sea both diffusive and finger regime are observed and the flow is inferred to be isopycnal (more stable statically). Typical heat and salt fluxes due to DDC are found to be 6 W/m2 and 0.36 W/m2 respectively. Effective salinity diffusivity, Ks and heat diffusivity, Kr have been estimated for the places with DDC in the Persian Gulf and Oman Gulf (Ks=1.1 *10-7 m2/s, KT= 1.88*10-6 m2/s). Their values are within the values obtained by others. The buoyancy frequency for the Persian Gulf with typical mean value of 0.05s-1 is much higher than these of the free Oceans. Such large values of N (typically 0.05 s-1) indicate that processes such as tide can produce strong internal waves which may be another factor in producing layered structures. This requires separate study.

Integracja europejska w mikroperspektywie. Graniczne miasta blizniacze w Europie Zachodniej i Srodkowo-Wschodniej

The dynamization of integration processes in Europe has generated numerous research topics for political analysis. Border integration is an expression of the broader unification processes of certain structures. It is also a manifestation of the observation that people think globally, but function locally. The European integration perspective is therefore practically implemented in micro structures, exemplified by border twin towns. The objective of this paper is to revive the micro perspective as a useful approach in the investigation of integration processes. This perspective is applied in the field of border studies, which focus on research into the transformation of European borders resulting from integration processes, as well as on the transformations of the concepts of statehood, territoriality and sovereignty. It is assumed that these phenomena are definitely more observable at the outskirts of states than in their centers. Theoretical and empirical considerations are based on the example of border twin towns, as the European units of local government that integrate across borders. The main differences between the integration of towns in Western Europe and Central and Eastern Europe are also indicated in the analysis.

Unconventional Ni–P alloy-catalyzed CVD of carbon coil-like micro- and nano-structures

Conventional catalyzed thermal CVD of carbon microcoils commonly suffers from poor control of the coil shape and morphology and rarely reaches the nanoscale size range. This article reports on an unconventional Ni-P alloy-catalyzed, high-throughput, highly reproducible CVD of ultra-long carbon coil-like micro- and nano-structures using acetylene precursor at relatively low process temperatures. Helical carbon microcoils with consistently uniform, circular cross-sections and a high degree of crystallinity have been synthesized at 750 °C. A further reduction of the temperature to 650 °C led to the growth of ultra-long (up to several mm) wave-like carbon nanofibers made of two nanowires with the diameters in the 100-200 nm range. The results of the XRD and Raman analysis reveal that the nanofibers feature only a slightly more disordered structure compared to the microcoils. Our results suggest that morphology and structure of the carbon coil-like micro- and nano-structures can be tailored by the appropriate alloying of the catalyst and the choice of the CVD process parameters.

Single voxel Magnetic Resonance Spectroscopic (1H-MRS) analysis of deep brain structures after traumatic prefrontal brain injury (TBI) in rat

Chronic difficulties arising from mild brain injury (TBI) are difficult to predict because the processes underlying changes after TBI are poorly understood. In mild brain injury the extent of neuropsychiatric and cognitive symptoms correspond poorly to overt tissue loss (Barth 1983; Liu 2010). Cellular, immune and hormonal cascades occurring after injury and continuing during the healing process may impact uninjured brain regions sensitive to the effects of physiological and emotional stress, which receive projections from the injury site. Changes in these most basic properties due to injury or disease have profound implications for virtually every aspect of brain function through disruption of neurotransmitter, neuroendocrine and metabolic systems. In order to screen for changes in transmitter and metabolic activity, in this study we developed Single voxel proton Magnetic Resonance Spectroscopy (1H-MRS) for use in both injured and control animals. We first evaluated if 1H-MRS could be used to evaluate in vivo, alterations in brain metabolism and catabolism of the prefrontal cortex, amygdala and ventral hippocampus in both control and injured animals after controlled cortical impact injury to the rat prefrontal cortex. We found that metabolite measurements for Myo-Inositol, Choline, creatine, Glutamate+Glutamine, and N-acetyl-acetate are attainable in deep brain structures in vivo in injured and controls rats. We next seek to evaluate longitudinally, in vivo, alterations in brain metabolism and catabolism of the prefrontal cortex, amygdala and ventral hippocampus during the first month after controlled cortical impact injury to the rat prefrontal cortex. These ongoing studies will provide data on the changes in transmitters and metabolites over time in injured and non-injured subjects. These studies address some of the fundamental questions about how mild brain injury has such diverse effects on overall brain health and function.

Paleomagnetic and rock magnetic study with emphasis on the Precambrian intrusions and impact structures in Fennoscandia and South Africa

The importance of supercontinents in our understanding of the geological evolution of the planet Earth has been recently emphasized. The role of paleomagnetism in reconstructing lithospheric blocks in their ancient paleopositions is vital. Paleomagnetism is the only quantitative tool for providing ancient latitudes and azimuthal orientations of continents. It also yields information of content of the geomagnetic field in the past. In order to obtain a continuous record on the positions of continents, dated intrusive rocks are required in temporal progression. This is not always possible due to pulse-like occurrences of dykes. In this work we demonstrate that studies of meteorite impact-related rocks may fill some gaps in the paleomagnetic record. This dissertation is based on paleomagnetic and rock magnetic data obtained from samples of the Jänisjärvi impact structure (Russian Karelia, most recent 40Ar-39Ar age of 682 Ma), the Salla diabase dyke (North Finland, U-Pb 1122 Ma), the Valaam monzodioritic sill (Russian Karelia, U-Pb 1458 Ma), and the Vredefort impact structure (South Africa, 2023 Ma). The paleomagnetic study of Jänisjärvi samples was made in order to obtain a pole for Baltica, which lacks paleomagnetic data from 750 to ca. 600 Ma. The position of Baltica at ca. 700 Ma is relevant in order to verify whether the supercontinent Rodinia was already fragmented. The paleomagnetic study of the Salla dyke was conducted to examine the position of Baltica at the onset of supercontinent Rodinia's formation. The virtual geomagnetic pole (VGP) from Salla dyke provides hints that the Mesoproterozoic Baltica - Laurentia unity in the Hudsonland (Columbia, Nuna) supercontinent assembly may have lasted until 1.12 Ga. Moreover, the new VGP of Salla dyke provides new constraint on the timing of the rotation of Baltica relative to Laurentia (e.g. Gower et al., 1990). A paleomagnetic study of the Valaam sill was carried out in order to shed light into the question of existence of Baltica-Laurentia unity in the supercontinent Hudsonland. Combined with results from dyke complex of the Lake Ladoga region (Schehrbakova et al., 2008) a new robust paleomagnetic pole for Baltica is obtained. This pole places Baltica on a latitude of 10°. This low latitude location is supported also by Mesoproterozoic 1.5 1.3 Ga red-bed sedimentation (for example the Satakunta sandstone). The Vredefort impactite samples provide a well dated (2.02 Ga) pole for the Kaapvaal Craton. Rock magnetic data reveal unusually high Koenigsberger ratios (Q values) in all studied lithologies of the Vredefort dome. The high Q values are now first time also seen in samples from the Johannesburg Dome (ca. 120 km away) where there is no impact evidence. Thus, a direct causative link of high Q values to the Vredefort impact event can be ruled out.

Cu-II-Azide Polymers of Cu-3 and Cu-6 Building Units: Synthesis,Structures, and Magnetic Exchange Mechanism

Two new neutral copper-azido polymers [Cu-3(N-3)(6)(tmen)(2)](n)(1)and [Cu-6(N-3)(12)(deen)(2)](n) (2) [tmen = N,N,N, N-tetramethylethylenediamine and deen = N,N-diethylethylenediamine] have been synthesized by using lower molar equivalents of the chelating diamine ligands with Cu(NO3)(2)center dot 3H(2)O and an excess of NaN3. The single crystal X-ray structure shows that in the basic unit of the 1D complex 1, the three Cu-II ions are linked by double end-on azido bridges with Cu-N-EO-Cu angles on both sides of the magnetic exchange critical angle of 108 degrees. Complex 2 is a 3D framework of a basic u-6 cluster. Cryomagnetic susceptibility measurements over a wide range of temperature exhibit dominant ferromagnetic behavior in both the complexes. Density functional theory calculations (B3LYP functional) have been performed on the trinuclear unit to provide a qualitative theoretical interpretation of the overall ferromagnetic behavior shown by the complex 1.

Co(II) and Cr(III) complexes of formate-formamide mixed ligands: synthesis, structures, single crystal-to-single crystal transformation and magnetic behaviour

Solvothermal treatment of an equimolar mixture of Co(NO3)(2)center dot 6H(2)O, HCONH2 and NaN3 in MeOH at 100 degrees C yielded a three-dimensional NaCl type network Co(HCOO)(2)(HCONH2)(2) center dot HCONH2 (1a) containing formamides in the pores of the structure. Solvated pink 1a undergoes single crystal-to-single crystal (SCSC) transformation at 215 degrees C to form the desolvated dark brown product Co(HCOO)(2)-( HCONH2)(2) (1b) with the retention of the original framework. Reversible single crystal-to-single crystal transformation of 1b (brown) to 1a (pink) in the presence of excess formamide was also established at room temperature. The coordination environment around Co(II) in both 1a and 1b is octahedral with a CoN2O4 coordination composition. A similar reaction replacing Co(II) by Cr(III) produced a heterometallic 3D extended network Na[Cr(HCOO)(4)(HCONH2)(2)]center dot 2H(2)O (2a) at 100 degrees C. An increase in reaction temperature to 150 degrees C produced a simple mononuclear complex Cr(HCOO)(3)(HCONH2)(3) center dot 3H(2)O (2b). Variable temperature magnetic studies revealed the presence of a canting phenomena in both 1a and 1b, and hysteresis loop in the field dependent magnetisation plot at 2 K whereas complex 2a is simply paramagnetic in nature.