Impact of FLT3 Internal Tandem Duplication on the Outcome of Related and Unrelated Hematopoietic Transplantation for Adult Acute Myeloid Leukemia in First Remission: A Retrospective Analysis

Purpose Patients with acute myeloid leukemia (AML) and FLT3/internal tandem duplication (FLT3/ITD) have poor prognosis if treated with chemotherapy only. Whether this alteration also affects outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) remains uncertain. Patients and Methods We analyzed 206 patients who underwent HLA-identical sibling and matched unrelated HSCTs reported to the European Group for Blood and Marrow Transplantation with a diagnosis of AML with normal cytogenetics and data on FLT3/ITD (present: n = 120, 58%; absent: n = 86, 42%). Transplantations were performed in first complete remission (CR) after myeloablative conditioning. Results Compared with FLT3/ITD-negative patients, FLT3/ITD-positive patients had higher median leukocyte count at diagnosis (59 v 21 x 10(9)/L; P < .001) and shorter interval from CR to transplantation (87 v 99 days; P = .04). Other characteristics were similar in the two groups. At 2 years, relapse incidence (RI; +/- standard deviation) was higher (30% +/- 5% v 16% +/- 5%; P = .006) and leukemia-free survival (LFS) lower (58% +/- 5% v 71% +/- 6%; P = .04) in FLT3/ITD-positive compared with FLT3/ITD-negative patients. In multivariate analyses, FLT3/ITD led to increased RI (hazard ratio [HR], 3.4; 95% CI, 1.46 to 7.94; P = .005), as did older age, female sex, shorter interval between CR and transplantation, and higher number of chemotherapy courses before achieving CR. FLT3/ITD positivity was associated with decreased LFS (HR, 0.37; 95% CI, 0.19 to 0.73; P = .002), along with older age and higher number of chemotherapy courses before achieving CR. Conclusion FLT3/ITD adversely affected the outcome of HSCT in the same direction it does after chemotherapy; despite this, more than half of the patients harboring this mutation who received transplants were alive and leukemia free at 2 years. To further improve the results, use of FLT3 inhibitors before or after HSCT deserves investigation.

Self-control strength in the relation between trait test anxiety and state anxiety

The present research examined whether in a test situation, the relation between trait test anxiety and state anxiety depends on the momentary availability of self-control strength. Since self-control strength is crucial for emotion regulation, we assume that trait test anxiety is more closely related to state anxiety if self-control strength is depleted than if it is not depleted. We conducted an experiment with 119 undergraduates in which we measured trait test anxiety, manipulated availability of self-control strength, and assessed state anxiety after a test announcement. Consistent with the assumption, multiple regression analyses revealed that trait test anxiety and state anxiety were positively related if self-control strength was depleted, but were not related if self-control strength was intact.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 741 - Abstimmung mit Arthur Schopenhauer in geschäftlichen Angelegenheiten

u.a.: Preisschrift Arthur Schopenhauers über die Freiheit des menschlichen Willens;

Conocimiento sobre alcoholismo y tabaquismo de los alumnos del tercer ciclo de la Educación General Básica (EGB3) de la escuela nº 1055 Corrientes y Josefa Capdevila nº 4-005, departamento de General San Martín

Se eligió a los alumnos de 12-13-14 años (EGB3: que son los alumnos de séptimo, octavo, noveno) porque es en la etapa de la adolescencia en la que se necesitan reforzar los conocimientos y la escuela es uno de los agentes de sociabilización y donde continúa el proceso educativo de la familia. La adolescencia es una de las etapas del ser humano más vulnerable y de grandes cambios mentales y físicos, donde el tabaco y el alcohol ha encontrado su huésped. Según datos obtenido de la Segunda Encuesta Nacional realizada en los años 2007 al 2008 de estadísticas de enseñanza media, de Mendoza las edades donde más consumo hay son 13, 15,17 existiendo una prevalencia, alarmante de 40 veces más del tabaco y 20 veces más para el alcohol en un mes, que 10 veces en un año de sustancias psicoactivas. En el departamento de San Martín también se está padeciendo esta problemática, que se vive a nivel mundial. Se observa que las familias están sufriendo un gran deterioro en su estructura y función y es por ello que se aparece esta gran predisposición al alcoholismo y tabaquismo en los adolescentes. El objetivo general de este trabajo es identificar qué conocimientos poseen sobre alcohol y tabaquismo los alumnos del tercer ciclo de la Educación General Básica (EGB -3), de las escuelas, Josefa Capdevila y Corrientes de San Martín Mendoza. Los objetivos específicos perseguidos fueron: 1-Lograr que los alumnos reconozcan las consecuencias directas e indirectas que tienen dichas sustancias en el organismo y que puedan generar enfermedades irreversibles. 2-Determinar si los alumnos conocen los riesgos a futuro que pueden causarles a su salud el tabaco y alcohol. 3- Reconocer el origen de la información que poseen (familia; vía publica, otra entidad educativa)

Introducción de la anticoncepción de emergencia en la Norma Oficial Mexicana de Planificación Familiar (NOM-005-SSA2-1993)

Population Council

Composition of suspended matter and bottom sediments from the Atlantic Ocean and its seas

The book summarizes data on distribution and composition of sedimentary material suspended in waters of the Atlantic Ocean and its seas. Results of observations of Soviet and foreign expeditions are given. Distribution of suspended matter in sections across the ocean, as well as in the most studied seas are shown. New data on grain size, mineral and chemical composition of suspended matter are published. Summary of history of investigation of bottom sediments from the Atlantic Ocean from the first scientific cruises to the present is done. A brief description of sediment types in the ocean and a detailed description of Mediterranean Sea sediments are given.