The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function.

Platelets in the circulation are triggered by vascular damage to activate, aggregate and form a thrombus that prevents excessive blood loss. Platelet activation is stringently regulated by intracellular signalling cascades, which when activated inappropriately lead to myocardial infarction and stroke. Strategies to address platelet dysfunction have included proteomics approaches which have lead to the discovery of a number of novel regulatory proteins of potential therapeutic value. Global analysis of platelet proteomes may enhance the outcome of these studies by arranging this information in a contextual manner that recapitulates established signalling complexes and predicts novel regulatory processes. Platelet signalling networks have already begun to be exploited with interrogation of protein datasets using in silico methodologies that locate functionally feasible protein clusters for subsequent biochemical validation. Characterization of these biological systems through analysis of spatial and temporal organization of component proteins is developing alongside advances in the proteomics field. This focused review highlights advances in platelet proteomics data mining approaches that complement the emerging systems biology field. We have also highlighted nucleated cell types as key examples that can inform platelet research. Therapeutic translation of these modern approaches to understanding platelet regulatory mechanisms will enable the development of novel anti-thrombotic strategies.

Creating Prestige and Global Networks through Conference Rituals

An international conference is a secular ritual which serves to create, recreate and shape global-wide translocal cultural sharings. Social anthropological theories and methods are used to show that, besides being an information flow junction, the international conference is a network crossroad and a way of socialising new members into aninternational research community. It is also capable of creating prestige and honour for the individual researcher,for the arranging research team, university and city. Rituals do not merely reflect the social relations or cosmology of a society, but are events that in themselves do important things through ritual forms and symbolic statements.

Solar Energy assessment based on weather station data for direct site monitoring in Indonesia

This thesis evaluates different sites for a weather measurement system and a suitable PV- simulation for University of Surabaya (UBAYA) in Indonesia/Java. The weather station is able to monitor all common weather phenomena including solar insolation. It is planned to use the data for scientific and educational purposes in the renewable energy studies. During evaluation and installation it falls into place that official specifications from global meteorological organizations could not be meet for some sensors caused by the conditions of UBAYA campus. After arranging the hardware the weather at the site was monitored for period of time. A comparison with different official sources from ground based and satellite bases measurements showed differences in wind and solar radiation. In some cases the monthly average solar insolation was deviating 42 % for satellite-based measurements. For the ground based it was less than 10 %. The average wind speed has a difference of 33 % compared to a source, which evaluated the wind power in Surabaya. The wind direction shows instabilities towards east compared with data from local weather station at the airport. PSET has the chance to get some investments to investigate photovoltaic on there own roof. With several simulations a suitable roof direction and the yearly and monthly outputs are shown. With a 7.7 kWpeak PV installation with the latest crystalline technology on the market 8.82 MWh/year could be achieved with weather data from 2012. Thin film technology could increase the value up to 9.13 MWh/year. However, the roofs have enough area to install PV. Finally the low price of electricity in Indonesia makes it not worth to feed in the energy into the public grid.

Simulation model using meta heuristic algorithms for achieving optimal arrangement of storage bins in a sawmill yard

Bin planning (arrangements) is a key factor in the timber industry. Improper planning of the storage bins may lead to inefficient transportation of resources, which threaten the overall efficiency and thereby limit the profit margins of sawmills. To address this challenge, a simulation model has been developed. However, as numerous alternatives are available for arranging bins, simulating all possibilities will take an enormous amount of time and it is computationally infeasible. A discrete-event simulation model incorporating meta-heuristic algorithms has therefore been investigated in this study. Preliminary investigations indicate that the results achieved by GA based simulation model are promising and better than the other meta-heuristic algorithm. Further, a sensitivity analysis has been done on the GA based optimal arrangement which contributes to gaining insights and knowledge about the real system that ultimately leads to improved and enhanced efficiency in sawmill yards. It is expected that the results achieved in the work will support timber industries in making optimal decisions with respect to arrangement of storage bins in a sawmill yard.

Bringing Japanese manufacturing systems to America: the feasibility of implementing just-in-time production in the United States

This paper addresses the feasibility of implementing Japanese manufacturing systems in the United States. The recent success of Japanese transplant companies suggests that Just-In-Time (JIT) production is possible within America's industrial environment. Once American workers receive proper training, they have little difficulty participating in rapid setup procedures and utilizing the kanban system. Japanese transplants are gradually developing Japanese-style relationships with their American supplier companies by initiating long-term, mutually beneficial agreements. They are also finding ways to cope with America's problem of distance, which is steadily decreasing as an obstacle to JIT delivery. American companies, however, encounter Significant problems in trying to convert traditionally organized, factories to the JIT system. This paper demonstrates that it is both feasible and beneficial for American manufacturers to implement JIT production techniques. Many of the difficulties manufacturers experience center around a general lack of information about JIT. Once a company realizes its potential for setup-time reduction, a prerequisite for the JIT system, workers and managers can work together to create a new process for handling equipment changeover. Significant results are possible with minimal investment. Also, supervisors often do not realize that the JIT method of ordering goods from suppliers is compatible with current systems. This "kanban system" not only enhances current systems but also reduces the amount of paperwork and scheduling involved. When arranging JlT delivery of supplier goods, American manufacturers tend to overlook important aspects of JIT supplier management. However, by making long-tenn commitments, initiating the open exchange of information, assisting suppliers in reaching new standards of performance, increasing the level of conununication, and relying more on suppliers' engineering capabilities, even American manufacturers can develop Japanese-style supplier relationships that enhance the effectiveness of the system.

A inteligência competitiva como difusora da ação estratégica: diagnóstico do setor vinícola de Bento Gonçalves - RS

The transformation that occurs in the scenery of the companies at this moment, leads them to a competitive environment, making exist more demands of the organizations, turning them more efficient. The companies search each time for more knowledge to follow this transformation, existing the concerning in the adequate way of arranging an organizational strategy that really works. The companies that really get to stand out through a clear, flexible and evolutive strategy have some strength that leads them, followed by directed information to the development of this strategy. This essay analyses the competitive intelligence of the winegrowing sector of Bento Gonçalves, through the establishment of the variable motive-power, organizational strategy and distinguished information. This way, we seek to make a research of this sector improving its peculiarities. The essay starts with the definition of the problem, characterizing the sector through a historic, problem and studied theme. On the theoretical reference, there is an evolution through the variable considered vital to the instauration of the competitive intelligence, beginning from the information to motive-power, organizational strategy, to the strategic information directed to the action. The results of this essay are in a chapter (Competitive Intelligence Analysis), which has the objective to analyze the research through a diagnosis of the winegrowing sector. This essay evaluates the winegrowing sector of Bento Gonçalves, with clear and defined strategies according to its objectives, but it¿s still not achieving in its greatest part to establish an organizational competitive intelligence.

Implementação da política de educação inclusiva nos municípios do Estado de São Paulo: um estudo de caso do município do Guarujá

A presente dissertação de mestrado tem como propósito expor as discussões acerca da temática da implementação da política de educação inclusiva em municípios, destacando e analisando o caso do município de Guarujá. Os objetivos deste trabalho são descrever a implementação da política de educação inclusiva nos municípios e analisar sua rede de atores relevantes. Observando recentes pesquisas sobre a temática, pretende-se discutir a influência do governo federal nessa implementação nos governos subnacionais e discutir a questão federativa na educação, no campo da educação inclusiva. A pesquisa levantou as leis, decretos, declarações e normatizações e os principais planos governamentais e programas que estão conectados ao tema, organizando-os em uma perspectiva histórica. Os principais modelos teóricos utilizados nessa análise são sobre o formato de rede e a perspectiva de jogo na implementação de políticas públicas. Para que essas análises fossem possíveis, observou-se a experiência do município do Guarujá na implementação da política pública de educação inclusiva durante os anos de 2009 a 2012. Levantaram-se dados sobre essa política, que foram organizados para a presente análise, tendo como foco a gestão municipal.

Template-based fluoropolymer ferroelectrets with multiple layers of tubular channels

Significant efforts are devoted to developing new ferroelectrets with well-controlled void distributions or uniform voids and with good long-term and thermal stability of the piezoelectricity. Here, we describe the concept, the fabrication, and the most relevant properties of fluoropolymer ferroelectret systems with three separate films of fluoroethylenepropylene (FEP), alternating with two polytetrafluoroethylene (PTFE) templates. The FEP films are selectively fused by means of a lamination process. Two practically identical PTFE templates are used, which have parallel rectangular openings (1.5×30 mm 2) separated by PTFE ridges of 1.5 mm width. After removing the PTFE templates, a three-layer FEP-film sandwich with tubular channels is obtained. We demonstrate that such FEP-film systems exhibit significant and stable piezoelectricity after charging under a high DC voltage. The resulting piezoelectric effect may be further improved by carefully assembling and arranging the PTFE templates during preparation. ©2010 IEEE.

Los efectos de los desastres en 2004 y 2005: la necesidad de adaptación de largo plazo

Incluye Bibliografía

Letramento digital e letramento escolar: uma abordagem linguística da prática de escrita em blogs

Pós-graduação em Estudos Linguísticos - IBILCE

Métodos metaheurísticos aplicados a um modelo de planejamento de culturas

Pós-graduação em Biometria - IBB

Características e impacto socioeconómico de los huracanes Stan y Wilma en la República Mexicana en el 2005

Incluye Bibliografía

A política nacional de proteção da natureza e seus desdobramentos no território do Parque Nacional dos Lençóis Maranhenses

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação do desempenho de alunos na elaboração do problema de pesquisa em um programa de ensino informatizado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Perfil geográfico multivariado da água consumida no município de Botucatu

Pós-graduação em Biometria - IBB