Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning

STUDY OBJECTIVE: Measurement of acetylcholinesterase (AChE) is recommended in the management of organophosphorus poisoning, which results in 200,000 deaths worldwide annually. The Test-mate ChE 400 is a portable field kit designed for detecting occupational organophosphorus exposure that measures RBC AChE and plasma cholinesterase (PChE) within 4 minutes. We evaluate Test-mate against a reference laboratory test in patients with acute organophosphorus self-poisoning. METHODS: This was a cross-sectional comparison study of 14 patients with acute organophosphorus poisoning between May 2007 and June 2008. RBC AChE and PChE were measured in 96 and 91 samples, respectively, with the Test-mate ChE field kit and compared with a reference laboratory, using the limits of agreement method (Bland and Altman), κ statistics, and Spearman's correlation coefficients. RESULTS: There was good agreement between the Test-mate ChE and the reference laboratory for RBC AChE. The mean difference (Test-mate-reference) was -0.62 U/g hemoglobin, 95% limits of agreement -10.84 to 9.59 U/g hemoglobin. Good agreement was also observed between the categories of mild, moderate, and severe RBC AChE inhibition (weighted κ 0.85; 95% confidence interval [CI] 0.83 to 0.87). Measurement of PChE also showed good agreement, with a mean difference (Test-mate-reference) of +0.06 U/mL blood, 95% limits of agreement -0.41 to 0.53 U/mL blood. Spearman's correlation coefficients were 0.87 (95% CI 0.81 to 0.91) for RBC AChE and 0.76 (95% CI 0.66 to 0.84) for PChE. Analysis for within-subject correlation of subjects did not change the limits of agreement. CONCLUSION: The Test-mate ChE field kit reliably provides rapid measurement of RBC AChE in acute organophosphorus poisoning.

National Conference on Wood Transportation Structures /

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An investigation of truck size and weight limits - technical supplement. Volume 2: truck and rail cost effects of truck size and weight limits. Final report.

Transportation Department, Office of the Assistant Secretary for Policy and International Affairs, Washington, D.C.

An investigation of truck size and weight limits - technical supplement. Volume 3: truck and rail fuel effects of truck size and weight limits.

Transportation Department, Office of the Assistant Secretary for Policy and International Affairs, Washington, D.C.

Development of transit coach bonded brake lining test equipment and test procedures. Progress report. Final report.

Urban Mass Transportation Administration, Washington, D.C.

Rail-highway crossing resource allocation model. Final report.

Federal Railway Administration, Office of Safety, Washington, D.C.

Annotated bibliography of rail transit safety, 1975-1980, with emphasis on safety research and development. Final report.

Urban Mass Transportation Administration, Washington, D.C.

Movable-bed laboratory experiments comparing radiation stress and energy flux factor as predictors of longshore transport rate /

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A lightweight pneumatic coring device : design and field test /

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A survey of national geocoding systems /

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Evaluation of retroreflective markings to increase rail car conspicuity -- safety of highway-railroad grade crossings.

Transportation Systems Center, Cambridge, Mass.

Workshops on technological change in the U.S. automobile industry October 1977 through April 1978 and the symposium on technology, government and the automotive future, October 19-20, 1978. Proceedings. Final report.

National Highway Traffic Safety Administration, Office of Research and Development, Washington, D.C.

Laboratory investigation of tidal inlets on sandy coasts /

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Hydraulics and dynamics of North Inlet, South Carolina, 1975-76 /

"September 1978."