Improvement of the effectiveness of motorist warnings at railroad highway grade crossings. Final report.

Federal Railroad Administration, Office of Research and Development, Washington, D.C.

Implementation guidelines for retiming arterial streets.

Texas Department of Transportation, Austin

Development of guidelines for installation of intersection control beacons. Final report.

Federal Highway Administration, Washington, D.C.

Evaluating the effectiveness of signal timing optimization based on microscopic simulation evaluation

The optimization of the timing parameters of traffic signals provides for efficient operation of traffic along a signalized transportation system. Optimization tools with macroscopic simulation models have been used to determine optimal timing plans. These plans have been, in some cases, evaluated and fine tuned using microscopic simulation tools. A number of studies show inconsistencies between optimization tool results based on macroscopic simulation and the results obtained from microscopic simulation. No attempts have been made to determine the reason behind these inconsistencies. This research investigates whether adjusting the parameters of macroscopic simulation models to correspond to the calibrated microscopic simulation model parameters can reduce said inconsistencies. The adjusted parameters include platoon dispersion model parameters, saturation flow rates, and cruise speeds. The results from this work show that adjusting cruise speeds and saturation flow rates can have significant impacts on improving the optimization/macroscopic simulation results as assessed by microscopic simulation models.

Rephasing of the intersection of city hall of Leiria

This project proposes two possible solutions for the phasing plan of the intersection near the City Hall of Leiria and presents the calculations of the cycle length and the intersection delay for both of them. The main goal of these solutions is to optimize the global functioning of the intersection. Since the number of cars that use an intersection is will fluctuate with time, when using pre-timed traffic lights, adjustments are needed to the settings of the traffic signals, to assure the accommodation of the present traffic flows in the intersection under acceptable conditions for drivers.

Aerodynamic Testing of Variable Message Signs

The increasing nationwide interest in intelligent transportation systems (ITS) and the need for more efficient transportation have led to the expanding use of variable message sign (VMS) technology. VMS panels are substantially heavier than flat panel aluminum signs and have a larger depth (dimension parallel to the direction of traffic). The additional weight and depth can have a significant effect on the aerodynamic forces and inertial loads transmitted to the support structure. The wind induced drag forces and the response of VMS structures is not well understood. Minimum design requirements for VMS structures are contained in the American Association of State Highway Transportation Officials Standard Specification for Structural Support for Highway Signs, Luminaires, and Traffic Signals (AASHTO Specification). However the Specification does not take into account the prismatic geometry of VMS and the complex interaction of the applied aerodynamic forces to the support structure. In view of the lack of code guidance and the limited number research performed so far, targeted experimentation and large scale testing was conducted at the Florida International University (FIU) Wall of Wind (WOW) to provide reliable drag coefficients and investigate the aerodynamic instability of VMS. A comprehensive range of VMS geometries was tested in turbulence representative of the high frequency end of the spectrum in a simulated suburban atmospheric boundary layer. The mean normal, lateral and vertical lift force coefficients, in addition to the twisting moment coefficient and eccentricity ratio, were determined using the measured data for each model. Wind tunnel testing confirmed that drag on a prismatic VMS is smaller than the 1.7 suggested value in the current AASHTO Specification (2013). An alternative to the AASHTO Specification code value is presented in the form of a design matrix. Testing and analysis also indicated that vortex shedding oscillations and galloping instability could be significant for VMS signs with a large depth ratio attached to a structure with a low natural frequency. The effect of corner modification was investigated by testing models with chamfered and rounded corners. Results demonstrated an additional decrease in the drag coefficient but a possible Reynolds number dependency for the rounded corner configuration.

Iowa Motor Vehicle Fuel Reduction Program, 1989

This report documents the results of a three million dollar traffic signal improvement demonstration program, known as the Iowa Motor Vehicle Fuel Reduction Program (the program). The program was funded with the use of oil overcharge funds and administered by the Iowa Departments of Natural Resources and Transportation. The objective of the program was to provide restitution to overcharged motorists by improving the efficiency of traffic signals. More efficient traffic signals reduce fuel consumption, delay, travel time, and automobile pollution while improving traffic safety. The program demonstrated the effectiveness of improving traffic signals and resulted in a 14.20-to-1 benefit-to-cost ratio.

BIKE – Bicycle Knowledge Explorer (Palm Beach)

This route planner, funded by the Palm Beach Metropolitan Planning Organization (MPO), is a joint effort by Florida International University GIS Center and University of Florida Geomatics Program at Fort Lauderdale Research and Education Center. It is designed as a planning tool for bicyclists. Assistance was received from the Palm Beach County Bicycle, Greenways, Pedestrian Advisory Committee.

BIKE – Bicycle Knowledge Explorer [Miami-Dade]

This route planner, funded by the Miami-Dade Metropolitan Planning Organization(MPO), is a joint effort by Florida International University GIS Center and University of Florida Geomatics Program at Fort Lauderdale Research and Education Center. It is designed as a planning tool for bicyclists. Assistance was received from the Miami-Dade County Bicycle/Pedestrian Advisory Committee and various cyclists and transportation professionals.

BIKE – Bicycle Knowledge Explorer [Broward County]

This route planner, funded by the Broward Metropolitan Planning Organization (MPO), is a joint effort by Florida International University GIS Center and University of Florida Geomatics Program at Fort Lauderdale Research and Education Center. It is designed as a planning tool for bicyclists. Assistance was received from the Broward County Bicycle/Pedestrian Advisory Committee and various cyclists and transportation professionals.

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

TGR5 is a G protein-coupled receptor that mediates bile acid (BA) effects on energy balance, inflammation, digestion and sensation. The mechanisms and spatiotemporal control of TGR5 signaling are poorly understood. We investigated TGR5 signaling and trafficking in transfected HEK293 cells and colonocytes (NCM460) that endogenously express TGR5. BAs (deoxycholic acid, DCA, taurolithocholic acid, TLCA) and the selective agonists oleanolic acid (OA) and 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N, 5-dimethylisoxazole-4-carboxamide (CCDC) stimulated cAMP formation but did not induce TGR5 endocytosis or recruitment of β-arrestins, assessed by confocal microscopy. DCA, TLCA and OA did not stimulate TGR5 association with β-arrestin 1/2 or G protein-coupled receptor kinase (GRK) 2/5/6, determined by bioluminescence resonance energy transfer. CCDC stimulated a low level of TGR5 interaction with β-arrestin2 and GRK2. DCA induced cAMP formation at the plasma membrane and cytosol, determined using exchange factor directly regulated by cAMP (Epac2)-based reporters, but cAMP signals did not desensitize. AG1478, an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, the metalloprotease inhibitor batimastat, and methyl-β-cyclodextrin and filipin, which block lipid raft formation, prevented DCA stimulation of extracellular signal regulated kinase (ERK1/2). BRET analysis revealed TGR5 and EGFR interactions that were blocked by disruption of lipid rafts. DCA stimulated TGR5 redistribution to plasma membrane microdomains, localized by immunogold electron microscopy. Thus, TGR5 does not interact with β-arrestins, desensitize or traffic to endosomes. TGR5 signals from plasma membrane rafts that facilitate EGFR interaction and transactivation. An understanding of the spatiotemporal control of TGR5 signaling provides insights into the actions of BAs and therapeutic TGR5 agonists/antagonists.

Traffic Routes and Signals for the Tonoplast

Tonoplast, the membrane delimiting plant vacuoles, regulates ion, water and nutrient movement between the cytosol and the vacuolar lumen through the activity of its membrane proteins. Correct traffic of proteins from the endoplasmic reticulum (ER) to the tonoplast requires (i) approval by the ER quality control, (ii) motifs for exit from the ER and (iii) motifs that promote sorting to the tonoplast. Recent evidence suggests that this traffic follows different pathways that are protein-specific and could also reflect vacuole specialization for lytic or storage function. The routes can be distinguished based on their sensitivity to drugs such as brefeldin A and C834 as well as using mutant plants that are defective in adaptor proteins of vesicle coats, or dominant-negative mutants of Rab GTPases.

Visibility and spacing of lane control signals for freeway traffic management.

Texas Department of Transportation, Austin

Signals, traffic software, and lighting: courses and basic references.

Mode of access: Internet.

Manual of regulations for official traffic signs, signals and markings.

"Revises and supersedes the Manual of regulations published in 1943."