A novel DNA-binding motif in MarA: The first structure for an AraC family transcriptional activator

A crystal structure for a member of the AraC prokaryotic transcriptional activator family, MarA, in complex with its cognate DNA-binding site is described. MarA consists of two similar subdomains, each containing a helix–turn–helix DNA-binding motif. The two recognition helices of the motifs are inserted into adjacent major groove segments on the same face of the DNA but are separated by only 27 Å thereby bending the DNA by ≈35°. Extensive interactions between the recognition helices and the DNA major groove provide the sequence specificity.

Workshop on Schizophrenia

On November 29–30, 1995, the National Academy of Sciences and the Institute of Medicine brought together experts in schizophrenia and specialists in other areas of the biological sciences in a workshop aimed at promoting the application of the latest biological information to this clinical problem. The workshop paid particular attention to evidence of pathology in the brains of people with schizophrenia, and to the possibility that this reflects an abnormality in brain development that eventually leads to the appearance of symptoms. The participants were impressed with the complexity of the problem, and felt that multiple approaches would be required to understand this disease. They recommended that a major focus should be on the search for predisposing genes, but that there should be parallel research in many other areas.

The sponges / by Robert von Lendenfeld.

v.42 (1915) text

Samīr al-Amīr: Ḥāshiyat ʻAbd al-Ḥakīm ibn Makhlūf al-Badawī al-Ḥanafī ʻalá Shar��� al-Muḥaqqiq al-Amīr li-basmalat Shar��� al-Mullawī al-Ṣaghīr ʻalá al-Samarqandīyah fī al-bayān

"Wa-qad ṭarraza al-muḥashshī nuskhatahu allatī ashkhaṣahā ilaynā lil-taṣḥīḥ ʻalayhā bi-ḥawāshin raqīqah wa-nafāʼis anīqah wa-ashāra bi-waḍʻihā maḍbūṭah bi-al-ʻadad qawlah baʻda qawlah fa-ajabnāhu ilá ṭalabihi kamā ajabnāhu ilá taṣdīr al-ṣaḥīfah bi-ʻibārat al-Amīr wa-irdāfihā bi-Samīrihi."

Chemical composition of basalts from ODP Leg 115

Leg 115 of the Ocean Drilling Program recovered basalts from four locations along the hotspot track that leads from the Deccan flood basalts in India to Reunion Island in the western Indian Ocean (Sites 706, 707, 713, and 715). The drilled basalts range in age from 35 Ma (Site 706) to 64 Ma (Site 707), and including the Deccan basalts (66 to 68 Ma), Mauritius Island (0.2 to 8 Ma), and Reunion Island (0 to 2 Ma), seven sites are provided for sampling the volcanic record of the 5000-km-long hotspot track. Chemical and age comparisons indicate that Site 707 lavas correlate with basalt units near the top of the Deccan flood basalt sequence. The lavas of Site 715 (55 to 60 Ma) are most similar to the islands of Mauritius and Reunion. Site 713 basalts (48 Ma) are similar to the earliest lavas of the Deccan province, and Site 706 basalts are intermediate in chemistry between those of central Indian spreading-ridge basalts and Reunion. Differences in lava compositions along the hotspot track can be related to variable mixing of plume and asthenospheric mantle, depending on the changing position of spreading-ridge segments and the hotspot during the opening of the Indian Ocean. Alternatively, time-dependent changes in the composition of hotspot melts may be due to a decrease in partial melting of a heterogeneous plume or to intrinsic changes in the composition of material supplied by the plume.

Beschreibendes Verzeichnis der illuminierten Handschriften in Österreich,

N. F., I- Bd.: Publikationen des Zweiten Kunsthistorischen Instituts der Universität Wien, in Verbindung mit dem Österreichischen Institut für Geschichtsforschung.

King's College lectures on immortality,

Imperfect: Title page wanting.

James R. Mann. Memorial addresses delivered in the House of Representatives of the United States in memory of James R. Mann, late a representative from Illinois. Sixty-seventh Congress. January 14, 1923.

"Proceedings in the Senate": p. 109-[113]

The Corsican; a diary of Napoleon's life in his own words, comp. by R. M. Johnston.

Mode of access: Internet.

Two lectures on population : delivered before the University of Oxford, in Easter term, 1828 ; to which is added, a correspondence between the author and T.R. Malthus.

Mode of access: Internet.

Adhesive bonding of titanium and its alloys /

"August 1965."

Esquisses critiques.

Includes index.

Stone's silent reading. Book 1-

Book one- illustrated by Ruth Julien Best.

Practical tables in meteorology and hypsometry : being the appendix to the paper On the use of the barometer on surveys and reconnaissances /

Chiefly tables.