Prominence of the dopamine D2 short isoform in dopaminergic pathways

As a result of alternative splicing, the D2 gene of the dopamine receptor family exists in two isoforms. The D2 long is characterized by the insertion of 29 amino acids in the third cytoplasmic loop, which is absent in the short isoform. We have produced subtype-specific antibodies against both the D2 short and D2 long isoforms and found a unique compartmentalization between these two isoforms in the primate brain. The D2 short predominates in the cell bodies and projection axons of the dopaminergic cell groups of the mesencephalon and hypothalamus, whereas the D2 long is more strongly expressed by neurons in the striatum and nucleus accumbens, structures targeted by dopaminergic fibers. These results show that the splice variants of the dopamine D2 receptor are differentially distributed and possess distinct functions. The strategic localization of the D2 short isoform in dopaminergic cell bodies and axons strongly suggests that this isoform is the likely dopamine autoreceptor, whereas the D2 long isoform is primarily a postsynaptic receptor.

Aplicação de técnicas inteligentes com análise no domínio do tempo para reconhecimento de defeitos em motores de indução trifásicos

Os motores de indução trifásicos são os principais elementos de conversão de energia elétrica em mecânica motriz aplicados em vários setores produtivos. Identificar um defeito no motor em operação pode fornecer, antes que ele falhe, maior segurança no processo de tomada de decisão sobre a manutenção da máquina, redução de custos e aumento de disponibilidade. Nesta tese são apresentas inicialmente uma revisão bibliográfica e a metodologia geral para a reprodução dos defeitos nos motores e a aplicação da técnica de discretização dos sinais de correntes e tensões no domínio do tempo. É também desenvolvido um estudo comparativo entre métodos de classificação de padrões para a identificação de defeitos nestas máquinas, tais como: Naive Bayes, k-Nearest Neighbor, Support Vector Machine (Sequential Minimal Optimization), Rede Neural Artificial (Perceptron Multicamadas), Repeated Incremental Pruning to Produce Error Reduction e C4.5 Decision Tree. Também aplicou-se o conceito de Sistemas Multiagentes (SMA) para suportar a utilização de múltiplos métodos concorrentes de forma distribuída para reconhecimento de padrões de defeitos em rolamentos defeituosos, quebras nas barras da gaiola de esquilo do rotor e curto-circuito entre as bobinas do enrolamento do estator de motores de indução trifásicos. Complementarmente, algumas estratégias para a definição da severidade dos defeitos supracitados em motores foram exploradas, fazendo inclusive uma averiguação da influência do desequilíbrio de tensão na alimentação da máquina para a determinação destas anomalias. Os dados experimentais foram adquiridos por meio de uma bancada experimental em laboratório com motores de potência de 1 e 2 cv acionados diretamente na rede elétrica, operando em várias condições de desequilíbrio das tensões e variações da carga mecânica aplicada ao eixo do motor.

Psychometric properties of the School Anxiety Inventory-Short Version in Spanish secondary education students

Background: The School Anxiety Inventory (SAI) can be applied in different fields of psychology. However, due to the inventory’s administration time, it may not be useful in certain situations. To address this concern, the present study developed a short version of the SAI (the SAI-SV). Method: This study examined the reliability and validity evidence drawn from the scores of the School Anxiety Inventory-Short Version (SAI-SV) using a sample of 2,367 (47.91% boys) Spanish secondary school students, ranging from 12 to 18 years of age. To analyze the dimensional structure of the SAI-SV, exploratory and confirmatory factor analyses were applied. Internal consistency and test-retest reliability were calculated for SAISV scores. Results: A correlated three-factor structure related to school situations (Anxiety about Aggression, Anxiety about Social Evaluation, and Anxiety about Academic Failure) and a three-factor structure related to the response systems of anxiety (Physiological Anxiety, Cognitive Anxiety, and Behavioral Anxiety) were identified and supported. The internal consistency and test-retest reliability were determined to be appropriate. Conclusions: The reliability and validity evidence based on the internal structure of SAI-SV scores was satisfactory.

The need of a short ballot in Ohio;

Mode of access: Internet.

Musical moments : short selections in prose and verse for music lovers /

No. 15 of 275 numbered copies.

An introduction to the Hindustani language : comprising a grammar, and a vocabulary, English and Hindustani : also short stories and dialogues, short stories in Persian and Nagari characters ... and military words of command, Nagari and English /

Mode of access: Internet.

A short course in college mathematics, comprising thirty-six lessons on algebra, coordinate methods, and plane trigonometry,

Mode of access: Internet.

Notes for short course in design and control of asphaltic mixtures: sessions on asphaltic mixtures.

"Major credit for the preparation of the majority of the material in these notes goes to Mr. Francis N. Hveem."

Short studies in literature /

Mode of access: Internet.

Journal of a trip to Holland. Communicated during a short tour in the year 1817, in letters to his daughter.

Mode of access: Internet.

A journal of a residence during several months in London ; including excursions through various parts of England ; and a short tour in France and Scotland ; in the years 1823 and 1824.

First published in the Episcopal watchman, under title : Notes of a traveller.

The beauties of Poor Richard's almanack for the year 1760; being short essays in prose and verse, interspersed with moral hints, wise sayings and entertaining remarks.

Mode of access: Internet.

Trial of Jacob Barker, Thomas Vermilya, and Matthew L. Davis, for alleged conspiracy : testimony as reported by Hugh Maxwell, Esq., District Attorney, and certified for the use of the Supreme Court, by Ogden Edwards, Esq., the judge before whom the cause was tried at the Circuit, in August, 1827.

Trial in the Circuit Court for the First Judicial Circuit, New York City, June-July, 1827, for conspiracy to defraud the Morris Canal & Banking Company, the Fulton Bank and others.

Business customs, correspondence and short cuts in figures : a text book for schools and colleges /

Mode of access: Internet.

Isaac Pitman's short course in shorthand;

Mode of access: Internet.