Lin KERNS, The secret of secrets (Secreta secretorum). A modern translation, with introduction, of “The governance of princes", with a foreword by Elizabeth Matthew, Lewiston (New York), The Edwin Mellen Press, 2008, ISBN 978-0-7734-5118-6, 168 pp.

Fil: Cuccia, Emiliano Javier.

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

Mutant presenilins have been found to cause Alzheimer disease. Here, we describe the identification and characterization of HOP-1, a Caenorhabditis elegans presenilin that displays much more lower sequence identity with human presenilins than does the other C. elegans presenilin, SEL-12. Despite considerable divergence, HOP-1 appears to be a bona fide presenilin, because HOP-1 can rescue the egg-laying defect caused by mutations in sel-12 when hop-1 is expressed under the control of sel-12 regulatory sequences. HOP-1 also has the essential topological characteristics of the other presenilins. Reducing hop-1 activity in a sel-12 mutant background causes synthetic lethality and terminal phenotypes associated with reducing the function of the C. elegans lin-12 and glp-1 genes. These observations suggest that hop-1 is functionally redundant with sel-12 and underscore the intimate connection between presenilin activity and LIN-12/Notch activity inferred from genetic studies in C. elegans and mammals.

Basolateral Localization of the Caenorhabditis elegans Epidermal Growth Factor Receptor in Epithelial Cells by the PDZ Protein LIN-10

In Caenorhabditis elegans, the EGF receptor (encoded by let-23) is localized to the basolateral membrane domain of the epithelial vulval precursor cells, where it acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation. lin-10 acts in LET-23 receptor tyrosine kinase basolateral localization, because lin-10 mutations result in mislocalization of LET-23 to the apical membrane domain and cause a signaling defective (vulvaless) phenotype. We demonstrate that the previous molecular identification of lin-10 was incorrect, and we identify a new gene corresponding to the lin-10 genetic locus. lin-10 encodes a protein with regions of similarity to mammalian X11/mint proteins, containing a phosphotyrosine-binding and two PDZ domains. A nonsense lin-10 allele that truncates both PDZ domains only partially reduces lin-10 gene activity, suggesting that these protein interaction domains are not essential for LIN-10 function in vulval induction. Immunocytochemical experiments show that LIN-10 is expressed in vulval epithelial cells and in neurons. LIN-10 is present at low levels in the cytoplasm and at the plasma membrane and at high levels at or near the Golgi. LIN-10 may function in secretion of LET-23 to the basolateral membrane domain, or it may be involved in tethering LET-23 at the basolateral plasma membrane once it is secreted.

Functional morphology and ontogeny of Keichousaurus hui (Reptilia, Sauropterygia) / Kebang Lin --, Olivier Rieppel --.

n.s. no.39(1998)

The Justice Department's handling of the Yah Lin "Charlie" Trie case : hearing before the Committee on Governmental Affairs, United States Senate, One Hundred Sixth Congress, first session, September 22, 1999.

Shipping list no.: 2000-0170-P.

Cours élémentaire de teinture sur laine, soie, lin, chanvre et coton: et sur l'art d'imprimer les toiles /

All copies are signed by the editor and initialized by the author.

Opisanīe upotreblenīi︠a︡ lekal i priborov 3-kh lin. pi︠e︡khotnoĭ dragunskoĭ i kazachʹeĭ vintovok obrazt︠s︡a 1891 goda.

Romanized record.

The Wu Shih Shan trial. Rpeort of the case of chow Chang Kung, Lin King Ching, Loo King Fah, Sat Keok Min, directors of the Taou Shan Kwan Temple, at Wu Shih Shan, Foochow, versus Rev. John R. Wolfe, of the Church of England Missionary Society ...

Mode of access: Internet.

Zhen zheng Xiao lin guang ji : [si juan].

On double leaves, oriental style.

Un document inédit sur Antoine Vérard, libraire et imprimeur. Reseignements sur le prix des reliures, des miniatures, et des imprimés sur vélin au XVe siècle.

From the account book of Louis de Savoie, Duchess of Angoulême.

Zhu yin xin ci lin /

Xuan shou yi ban chang yong zi. Yong guo yin zi mu zhu yin. An bu shou jian suo.

Han lin Yang Zhonghong shi : 8 juan /

Ju Jiangnan tu shu guan cang Jiajing 15 nian Weng shi kan ben ying yin.