Linguagem e representação da realidade à luz das Investigações filosóficas de Ludwig Wittgenstein

Pós-graduação em Filosofia - FFC

Fragmento e montagem em Mauricio Kagel: uma análise de Ludwig Van

Pós-graduação em Música - IA

Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study

Background: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure.

A herança genotípica proposta por Wilhelm Ludwig Johannsen

Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq)

Investigação sobre a inclusão do episódio histórico da teoria genotípica de Wilhelm Ludwig Johannsen na formação inicial de professores e pesquisadores

This paper is part of a broader investigation on Epistemology of Biology carried out by a group of researchers from Cascavel/PR. It involves studies and research about biological thought on subjects such as the growing of the concepts of gene, genotype and phenotype. The aim of this research was to gather the undergraduate students of Biological Sciences’ views about the role played by the inclusion of a historical episode in the study group as a trigger for epistemological discussions and didactic reflections. Firstly, the students received Johannsen’s article “The genotype conception of heredity”, published in 1911 in the journal The American Naturalist, in which he proposed the concepts of genotype and phenotype, among other ones. After, there was a discussion held by group about the concepts proposed in the article taking into account the epistemological, historical and didactic aspects. Data collection occurred through the recording of the group discussions and individual interviews. The results suggest that the inclusion of this historical episode, enabled the participants to develop critical thinking through collective reflection on the meaning of biological knowledge in different contexts.

A produção técnico-científica de James Precott Joule: uma leitura a partir da epistemologia de Ludwig Fleck

This paper aims an epistemologically analysis of the attempt of James Prescott Joule to replace the steam engine by the electric one. In this historical analysis, we use the epistemological categories: style of thinking, collective thinking, intercollective circulation of ideas and practices,Joule and other technicians in Machester received in that time financial incentives from governments and industry to replace the steam engine by the electric one, since it was in Manchester a culture of the technique of the accuracy and precision in which Joule was immersed, which allowed us to initially identify the styles of techniques thinking and experimental efficiency. However, Joule could not replace the steam engine by the electric; and the awareness of the problems faced by him, in the attempt to make such a substitution, led him to seek, through an intercollective circulation of ideas and practices, such as the studies of Faraday and Jacobi, a change of direction in his researches. According to our analysis, what happened was a change of style from a technical to a scientific thinking. In this sense, Joule began to investigate issues of a scientific nature, as the Joule’s effect and the mechanical equivalent of heat, which contributed significantly to the establishment of the principle of conservation of energy. We present here the contributions of this epistemological analysis to the discussion of questions of the nature of science in the basic education and for the training of physics teachers.