Hedwig Jacobi, Alice Bendix, Anna Renner and Klara Mayer Portraits Groups Women

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Studio portrait of Gretel Heimann (on right) with her sister Anna Portraits Children

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Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

On the implication of the recently discovered 5 millisecond binary pulsar PSR 1855+09

e argue that the extraordinary fact that all three known millisecond pulsars are very close to the galactic plane implies that there must be ~100 potentially observable millisecond pulsars within ~4 kpc from the Sun. Our other main conclusion is that the dipole magnetic fields or old neutron stars probably saturate around 5 x 108 gauss.

Cora Berliner (dancing?) outdoors with an unidentified woman.

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Studio portrait of Cora Berliner with her mother and sister; Hannover Portraits Family

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Studio portrait of Anna Hoch Hauser seated and holding a copy of the book "Geschichten Aus Tirol" by Carl Wolf; Vienna Portraits Women

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Emilie Mosse and Anna Ginsberg walking in a park; Cape Martin Portraits; Groups; Women

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goldschmidt, anna; goldschmidt fritz Portraits Family

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goldschmidt anna; goldschmidt fritz; stolzenau Portraits Family

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goldschmidt anna (aenne ) Portraits Women

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goldschmidt anna (aenne) Portraits Women

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goldschmidt, max; goldschmidt lotte; goldschmidt fritz; goldschmidt frieda; heilbrunn lotte; goldscmidt anna; simon moses Portraits Family

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