Some materials towards memoirs of the reign of King George II,

Paged continuously.

The coinage of the Visigoths of Spain, Leovigild to Achila II.

Mode of access: Internet.

Several orations of Demosthenes, exciting the Athenians to oppose the exorbitant power of Philip King of Macedon.

Bound in old sprinkled calf.

The orations of Demosthenes : pronounced to excite the Athenians against Philip, King of Macedon /

Mode of access: Internet.

The orations of Demosthenes : pronounced to excite the Athenians against Philip, King of Macedon /

Mode of access: Internet.

Biography of the principal sovereigns of Europe who have reigned since the French Revolution : adorned with portraits of Their Majesties the King of Great Britain, the Emperors and Empresses of Austria and Russia, the Kings of Bavaria, Denmark, France, Netherlands, Portugal, Prussia, Sardinia, Saxony, Spain, Sweden, Two Sicilies, Wurtemberg, and the Grand Signior.

Mode of access: Internet.

The king in exile; the wanderings of Charles II. from June 1646 to July 1654,

Mode of access: Internet.

History of King Philip, sovereign chief of the Wampanoags.

Mode of access: Internet.

Shakespeare's tragedy of King Richard II;

"First issue of this edition ... printed 1895. Reprinted ... 1930."

The Spanish Armada, A. D. 1588 : or The attempt of Philip II and Pope Sixtus V to re-establish popery in England /

Mode of access: Internet.

Memoirs of the kings of Spain of the House of Bourbon, from the accession of Philip V. to the death of Charles III. 1700 to 1788. Drawn from original and unpublished documents.

Mode of access: Internet.

Noble States Managed by Women. Doña Teresa de Saavedra y Zúñiga, Countess of Villalonso: an Aristocrat during Philip II and Philip III’s Reign

This work intends to analyze the letters exchanged between doña Teresa de Saavedra y Zúñiga, countess of Villalonso, and Bartolomé de Cartagena, a merchant who lived in Seville. Those letters are a very detailed account of their financial relationship during two decades; but they also give us important information about the countess’ life. In her letters the countess discussed her domestic familial life but also made reference to her social position at Court, so we can reconstruct the strategies used by doña Teresa in order to accomplish all her objectives and the ways she used to present these goals to the others.

A phase II study of the modulation of 5-fluorouracil and folinic acid with high-dose infusional hydroxyurea in metastatic colorectal carcinoma

Background: Hydroxyurea (HU), an inhibitor of ribonucleotide reductase, may potentiate the activity of 5-fluorouracil (5-FU) and folinic acid (FA) by reducing the deoxyribonucleotide pool available for DNA synthesis and repair. However as HU may inhibit the formation of 5-fluoro-2-deoxyuridine-5- monophosphate (FdUMP), one of the principal active metabolites of 5-FU, the scheduling of HU may be critical. In vitro experiments suggest that administration of HU following 5-FU, maintaining the concentration in the region of I mM for six or more hours, significantly enhances the efficacy of 5-FU. Patients and methods: 5-FU/FA was given as follows: days 1 and 2 - FA 250 mg/m 2 (max. 350 mg) over two hours followed by 5-FU 400 mg/m 2 by intravenous bolus (ivb) over 15 minutes and subsequently 5-FU 400 mg/m 2 infusion (ivi) over 22 hours. HU was administered on day 3 immediately after the 5-FU with 3 g ivb over 15 minutes followed by 12 g ivi over 12 hours. Results: Thirty patients were entered into the study. Median survival was nine months (range 1-51 + months). There were eight partial responses (28%, 95% CI: 13%-47%). The median duration of response was 6.5 (range 4-9 months). Grade 3-4 toxicities included neutropenia (grade 3 in eight patients and grade 4 in five), anaemia (grade 3 in one patient) and diarrhoea (grade 3 in two patients). Neutropenia was associated with pyrexia in two patients. Phlebitis at the infusion site occurred in five patients. The treatment was complicated by pulmonary embolism in one patient and deep venous thrombosis in another. Conclusion: HU administered in this schedule is well tolerated. Based on these results and those of other phase II studies, a randomised phase III study of 5-FU, FA and HU versus 5-FU and FA using the standard de Gramont schedule is recommended.