Manejo prenatal de la anencefalia: consideraciones éticas y legales en la salud reproductiva

Texto traducido con autorización de la Federación Internacional de Ginecología y Obstetricia (FIGO): Cook, R. J., Erdman, J.N., Hevia, M, Dickens, B.M, Prenatal management of anencephaly. International Journal of Gynecology and Obstetrics.

Los derechos reproductivos: un debate necesario

Planned Parenthood Federation of America (PPFA) y el Centro de Promoción y Defensa de los Derechos Sexuales y Reproductivos (PROMSEX), como organizaciones auspiciantes del Primer Congreso Latinoamericano Jurídico sobre Derechos Reproductivos (Congreso Jurídico), quieren agradecer especialmente a Oscar Cabrera por sus aportaciones y su invaluable compromiso en coordinar, editar y escribir parte de esta publicación. Queremos expresar también nuestro profundo agradecimiento a las académicas que aportaron sus artículos sobre temas centrales para la región en relación al ejercicio de los derechos reproductivos. A ellas, Agustina Ramón Michell, Lidia Casas Becerra, Mercedes Cavallo y Claudia Ahumada, mil gracias. A las profesoras Rebecca Cook y Joanna Erdman y al profesor Bernard Dickens, nuestro sincero reconocimiento por su constante apoyo. Y un especial agradecimiento al Dr. Luis Lamas Puccio, ex vicedecano del Ilustre Colegio de Abogados de Lima, por su compromiso en la defensa de los derechos de las mujeres.

Air concentration of polybrominated diphenyl ethers around the Great Lakes and the Arctic

Atmospheric PBDEs were measured on a monthly basis in 2002-2004 at Point Petre, a rural site in the Great Lakes. Average air concentrations were 7.0 ± 13 pg/m**3 for the sum of 14BDE (excluding BDE-209), and 1.8 ± 1.5 pg/m**3 for BDE-209. Concentrations of 3 dominant congeners (i.e., BDE-47, 99, and 209) were comparable to previous measurements at remote/rural sites around the Great Lakes, but much lower than those at urban areas. Weak temperature dependence and strong linear correlations between relatively volatile congeners suggest importance of advective inputs of gaseous species. The significant correlation between BDE-209 and 183 implies their transport inputs associated with particles. Particle-bound percentages were found greater for highly brominated congeners than less brominated ones. These percentages increase with decreasing ambient temperatures. The observed gas/particle partitioning is consistent with laboratory measurements and fits well to the Junge-Pankow model. Using air mass back-trajectories, atmospheric transport to Point Petre was estimated as 76% for BDE-47, 67% for BDE-99, and 70% for BDE-209 from west-northwest and southwest directions. During the same time period, similar congener profiles and concentration levels were found at Alert in the Canadian High Arctic. Different inter-annual variations between Point Petre and Alert indicate that emissions from other regions than North America could also contribute PBDEs in the Arctic. In contrast to weak temperature effect at Point Petre, significant temperature dependence in the summertime implies volatilization emissions of PBDEs at Alert. Meanwhile, episodic observations in the wintertime were likely associated with enhanced inputs through long-range transport during the Arctic Haze period.

The Putative “Switch 2” Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein

Posttranslational modification of Rab proteins by geranylgeranyltransferase type II requires that they first bind to Rab escort protein (REP). Following prenylation, REP is postulated to accompany the modified GTPase to its specific target membrane. REP binds preferentially to Rab proteins that are in the GDP state, but the specific structural domains involved in this interaction have not been defined. In p21 Ras, the α2 helix of the Switch 2 domain undergoes a major conformational change upon GTP hydrolysis. Therefore, we hypothesized that the corresponding region in Rab1B might play a key role in the interaction with REP. Introduction of amino acid substitutions (I73N, Y78D, and A81D) into the putative α2 helix of Myc-tagged Rab1B prevented prenylation of the recombinant protein in cell-free assays, whereas mutations in the α3 and α4 helices did not. Additionally, upon transient expression in transfected HEK-293 cells, the Myc-Rab1B α2 helix mutants were not efficiently prenylated as determined by incorporation of [3H]mevalonate. Metabolic labeling studies using [32P]orthophosphate indicated that the poor prenylation of the Rab1B α2 helix mutants was not directly correlated with major disruptions in guanine nucleotide binding or intrinsic GTPase activity. Finally, gel filtration analysis of cytosolic fractions from 293 cells that were coexpressing T7 epitope-tagged REP with various Myc-Rab1B constructs revealed that mutations in the α2 helix of Rab1B prevented the association of nascent (i.e., nonprenylated) Rab1B with REP. These data indicate that the Switch 2 domain of Rab1B is a key structural determinant for REP interaction and that nucleotide-dependent conformational changes in this region are largely responsible for the selective interaction of REP with the GDP-bound form of the Rab substrate.

Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins.

Mycobacterium tuberculosis, the primary agent of tuberculosis, must acquire iron from the host to cause infection. To do so, it releases high-affinity iron-binding siderophores called exochelins. Exochelins are thought to transfer iron to another type of high-affinity iron-binding molecule in the bacterial cell wall, mycobactins, for subsequent utilization by the bacterium. In this paper, we describe the purification of exochelins of M. tuberculosis and their characterization by mass spectrometry. Exochelins comprise a family of molecules whose most abundant species range in mass from 744 to 800 Da in the neutral Fe(3+)-loaded state. The molecules form two 14-Da-increment series, one saturated and the other unsaturated, with the increments reflecting different numbers of CH2 groups on a side chain. These series further subdivide into serine- or threonine-containing species. The virulent M. tuberculosis Erdman strain and the avirulent M. tuberculosis H37Ra strain produce a similar set of exochelins. Based on a comparison of their tandem mass spectra, exochelins share a common core structure with mycobactins. However, exochelins are smaller than mycobactins due to a shorter alkyl side chain, and the side chain of exochelins terminates in a methyl ester. These differences render exochelins more polar than the lipophilic mycobactins and hence soluble in the aqueous extracellular milieu of the bacterium in which they bind iron in the host.

C4-C7 alkenones in deep sea sediments

It is believed that C4 to C7 hydrocarbons in petroleum are formed by the cracking of organic matter at depths generally exceeding 1,000 m at temperatures in excess of 50 °C (Cordel, 1972; Dow, 1974; Tissot et al., 1974)). Also, none of the alkanes in the butane-heptane range are formed biologically as far as is known at present. Consequently, it is thought that they do not occur in shallow, Recent sediments. In 1962, I analysed 22 samples of Recent sediments from 7 different environments and verified that these hydrocarbons were not present at the p.p.m. level (Dunton and Hunt, 1962) although traces of a few hydrocarbons such as butane, isobutane, isopentane and n-heptane have been found (Sokolov, 1957; Veber and Turkeltaub, 1958; Erdman et al., 1958; Emery and Hoggan, 1958). No identification of individual hexanes or heptanes has been reported except when there has been clear evidence of seepage from deeper source sediments (McIver, 1973).

1980 University of Michigan Baseball Team

Top Row: Coach Bud Middaugh, Scott Elam, Steve Ontiveros, Jaime Vela, Mickey Kazmeirski, Scott Dawson, trainer Pete Loubert,

4th Row: ground crew Leon Tweedy, Chris Shea, Fred Erdman Garry Gawrych, Tony Evans, Dan Sygar, Jeff Jacobson, equip. mngr. Adam White

3rd Row: mngr. Mike Thompson, Greg Schulte, Tim Karazin; Jim Paciorek, Tom Fredal, Charlie Arvai

2nd Row: asst. coach Dave Hall, Tim Miller, Randy Wroten, Mark Clinton, Gerry Hool, Joe Wissing

Front Row: Dave Nuss, Chuck Wagner, Sherm Stenson, Chris Kalis, George Foussaines, Pat Balaze

1981 University of Michigan Baseball Team

Top Row: stud. mngr. Charlie Peck, Dave Stober, Chris Sabo, Greg Schulte, Jim Bartlett, Chuck Froning, Dan Sygar, Rich Stoll, Jim Price, stud. mngr. Chris Jaksa

Middle Row: asst. coach Danny Hall, asst. coach Terry Hunter, Bill Shuta, Gary Wayne, Dave Knopf, Scot Elam, Rich Bair, Jeff Jacobson, Tony Evans, Steve Ontiveros, coach Bud Middaugh

Front Row: equip. mngr. Adam White, Jim Paciorek, Vic Ray, Mark Clinton, Tim Miller, Gerry Hool, Randy Wroten, Joe Wissing, John Young, Fred Erdman, trainer Rex Thompson,

1982 University of Michigan Baseball Team

Top Row: Mike Dadabbo, Jim Price, Matt Ruud, Mike McClear, Chuck Froning, Scott Young, C.J. Beske, Jeff Minick, Rich Stoll, Chris Jaksa

Middle Row: asst. coach Danny Hall, Chris Sabo, Bill Shuta, Rich Bair, John Clem, Dave Knopf, Ken Hayward, Jaime Vela, grad asst. Gary Murphy, coach Bud Middaugh

Front Row: equip. mngr. Adam White, Dan Sygar, Steve Ontiveros, Tim Karazin, Dave Stober, Greg Schulte, Jim Paciorek, John Young, Jeff Jacobson, Tony Evans, Fred Erdman, trainer Rex Thompson,

1983 University of Michigan Baseball Team

Top Row: trainer Rex Thompson, C.J. Beshke, Christopher Gust, Eric Sanders, Barry Larkin, John Codere, Derek Kerr, Dale Sklar, Jeff Minick, Mark Dadabbo, asst. trainer Bill Quinn

Middle Row: coach Bud Middaugh, grad. asst. Gary Murphy, groundskeeper Willis Parrott, Dan Disher, Casey Close, Jamie Piper, Kenneth Hayward, Michael Watters, Scott Kamienicki, Kurt Zimmerman, grad asst. John Young, asst. coach Danny Hall, equip. mngr. Tom Sears

Front Row: mngr. Chris Jaksa, Richard Bair, Gary Wayne, David Knopf, Daniel Sygar, Frederick Erdman, Jeffrey Jacobson, Timothy Karazim, Richard Stoll, Charles Froning, William Shuta, Chris Sabo

American produce markets,

Mode of access: Internet.

Marketing & cooperation ... Selected bulletins assembled

Mode of access: Internet.

Die heilige Sünde : ein Spiel in einem Akt /

Mode of access: Internet.