Enhancing Knowledge Acquisition in Pharmaceutical Organisations based in Pakistan

Absorptive Capacity (ACAP) depicts the sequential order of activities connecting externally generated knowledge into an organisation; this involves a company’s ability to acquire new knowledge from an external source, assimilate and transform it, and eventually exploit it via its industrial processes and products/services. The sandwiched role of middle managers, being interlinked between decision makers and employees, has been argued as vital to organisational success. However, their role is often viewed as having conflicts astride management i.e. between employees and decision makers. This study, using a thematic analysis approach, explores and identifies the common and conflicting role of middle managers, as viewed by different respondents in organisational hierarchies. Results, based on a sample of 33 employees operating in the Pakistan Pharmaceutical sector, indicate that conflicting roles of middle managers also persist with more common roles in organisations.

Ferramenta de gestão de conhecimento colectivo : KNOEY - Knowledge Embraces You

Mestrado em Ciências Empresariais

Studies on the Hippo Pathway: new insights about a multifaceted signalling

The Hippo pathway is a well-known master regulator of cell growth and proliferation. Many studies have shed light on the centrality of Hippo functions, as this signalling is able to respond to different stimuli and translate them into distinct transcriptional outputs. Therefore, it is clearly implicated in a number of important processes, which alteration has consequences on the correct specification of the single cell, as well as the whole tissue. Even if the core of the signalling has been extensively characterized, it remains unclear which are the “co-workers” that permit the Hippo pathway to answer to so many different stimuli and act as a coordinator of the growth/differentiation balance. Taking advantage of the Drosophila model, which has witnessed most of the discoveries on this signalling pathway, this thesis aims to add some new knowledge about the Hippo pathway molecular mechanisms in different contexts, from development to disease. In the first part I studied the dynamics of the Hippo core kinase protein Warts in the development of the pupal eye. I have found out a critical time point in which the expression and the localization of Warts change suddenly, suggesting the intervention of upstream regulators modulating its activity in an extremely narrow time window. The second goal was investigating the role of the Hippo pathway in the neurodegenerative Gaucher disease. Indeed, I have produced some preliminary results which demonstrate a growth deficit associated with a massive reduction of some Yki targets, supporting a Hyper-Hippo condition underlying this neuropathic syndrome. Finally, I have evaluated the transcription factor Orthodenticle as a co-factor of Yorkie in driving tissue overgrowth, and my findings support a model of interaction of these two molecules based on Yki conformational changes. Altogether, my results lay the foundation for new important studies on the molecular mechanisms ruling Hippo pathway activity.

Educação fisica adaptada : proposta de ação metodologica para formação universitaria

Universidade Estadual de Campinas. Faculdade de Educação Física

Educação para a água

A água como tema no contexto educacional é abordada a partir de diversas perspectivas. Diante das discussões em relação à crise socioambiental atual, acreditamos que a educação para a água deva ser realizada a partir da abordagem das dimensões espacial e temporal, considerando nesta última o tempo geológico e a história humana, sem a qual não é possível enfrentar a fragmentação do conhecimento que predomina no ambiente escolar. A abordagem do local, tendo como unidade de estudo a bacia hidrográfica, auxiliada pelos conteúdos das geociências e por metodologias interdisciplinares, proporciona uma visão integrada e contextualizada do tema para a construção do conhecimento.

Educação ambiental, sustentabilidade e ciência: o papel da mídia na difusão de conhecimentos científicos

São problemas de ordem ambiental: aquecimento global, mudanças climáticas, escassez de recursos naturais, resíduo. Em resposta, têm sido gerados novos saberes no campo da ciência, tecnologia e educação chamada ambiental de modo a se proporem alternativas para que o homem possa relacionar-se com o ambiente de maneira sustentável, e a mídia tem contribuído sobremaneira na veiculação desses conhecimentos. Na imprensa escrita, revistas e jornais têm criado seções, suplementos, cadernos tematizando educação e meio ambiente. Produzida pela revista Carta Capital, desde 2006, a revista Carta na Escola busca difundir "atualidades em sala de aula", e de setembro de 2007 a agosto de 2008 publicou a série "Sustentabilidade na Escola", com dez artigos relacionando sustentabilidade, ciência e educação. A partir do referencial teórico-metodológico da análise dialógica do discurso, este artigo analisa o discurso da sustentabilidade baseado na difusão de conhecimentos científicos, proposto nessa série, e sua limitação enquanto estratégia de educação ambiental.

Elderly online: Effects of a digital inclusion program in cognitive performance

There is little empirical data about the impact of digital inclusion on cognition among older adults. This paper aimed at investigating the effects of a digital inclusion program in the cognitive performance of older individuals who participated in a computer learning workshop named ""Idosos On-Line`` (Elderly Online). Forty-two aged individuals participated in the research study: 22 completed the computer training workshop and 20 constituted the control group. All subjects answered a sociodemographic questionnaire and completed the Addenbrooke`s cognitive examination, revised (ACE-R), which examines five cognitive domains: orientation and attention, memory, verbal fluency, language, and visuo-spatial skills. It was noted that the experimental group`s cognitive performance significantly improved after the program, particularly in the language and memory domains, when compared to the control group. These findings suggest that the acquisition of new knowledge and the use of a new tool, that makes it possible to access the Internet, may bring gains to cognition. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Calcium Carbonate Particle Growth Depending on Coupling among Adjacent Layers in Hybrid LB/LbL Films

There are practical and academic situations that justify the study of calcium carbonate crystallization and especially of systems that are associated with organic matrices and a confined medium. Despite the fact that many different matrices have been studied, the use of well-behaved, thin organic films may provide new knowledge about this system. In this work, we have studied the growth of calcium carbonate particles on well-defined organic matrices that were formed by layer-by-layer (LbL) polyelectrolyte films deposited on phospholipid Langmuir-Blodgett films (LB). We were able to change the surface electrical charge density of the LB films by changing the proportions of a negatively charged lipid, the sodium salt of dimyristoyl-sn-glycero-phosphatidyl acid (DMPA), and a zwitterionic lipid. dimyristoyl-sn-glycero-phosphatidylethanolamine (DMPE). This affects the subsequent polyelectrolyte LbL film deposition, which also changes the the nature of the bonding (electrostatic interaction or hydrogen bonding). This approach allowed for the formation of calcium carbonate particles of different final shapes, roughnesses, and sizes. The masses of deposited lipids, polyelectrolytes, and calcium cabonate were quantified by the quartz crystal microbalance technique. The structures of obtained particles were analyzed by scanning electron microscopy.

Advances in the diagnosis of primary immunodeficiency disorders in childhood

Primary immunodeficiency disorders in childhood usually present as unusual, recurrent or severe infections, symptomatic infections with organisms of low pathogenicity, or as recognizable syndromes which are known to have associated immunological abnormalities. In many of the primary immunodeficiency disorders, there are known patterns of inheritance, and other family members may be affected. Some primary immunodeficiency disorders are relatively common, such as selective IgA deficiency, and often do not lead to major morbidity. Others, such as the severe combined immune deficiency syndromes, are relatively rare, and are fatal in early life if not recognized and treated early. Diagnosis of a primary immunodeficiency disorder depends on appropriate use of laboratory investigations. Often there will be abnormalities detected on a complete blood film and measurement of immunoglobulin isotypes. More complex investigations should be undertaken in conjunction with a paediatric immunology service. In recent years, many of the clinically defined primary immunodeficiency disorders have been shown to have associated specific gene defects. For some, this has led to the identification and characterization of defective or absent gene products. The consequences of this new knowledge are more accurate diagnosis, early diagnosis including antenatal diagnosis, detection of undiagnosed disease in other family members, and the potential for new therapies including gene or gene product therapy.

A carreira de gestor p??blico e sua forma????o

Apesar de todo investimento nos ??ltimos anos, do poder p??blico, em qualificar profissionais, criar cursos e institui????es para forma????o de gestores p??blicos, o que parece ainda vigorar s??o as indica????es, para os cargos de gestores de unidades de sa??de. A carreira do Gestor P??blico na ??rea de sa??de deve ser feita atrav??s da Escola Nacional de Administra????o P??blica (ENAP), criada para tal fim, nos moldes atuais da carreira de Especialistas em Pol??ticas P??blicas e Gest??o Governamental (EPPGG) ou por outras Escolas como a Escola Nacional de Sa??de P??blica (ENSP). A????es e press??es de atores internacionais interferem na gest??o governamental, levando os governantes a promoverem reformas em suas administra????es visando atender esses interesses. Reformas administrativas ocorreram, em sua maioria, n??o por vontade do governo vigente, mas sim por v??rios fatores, sejam internos ou externos ao pa??s. Devido ao processo de globaliza????o e ao ide??rio neoliberal, que defendiam menor participa????o de interven????o do Estado na economia, reformas administrativas ocorreram e vem ocorrendo. Nos anos recentes, visando responder ??s demandas de novos conhecimentos e tecnologias colocadas pelo sistema de sa??de brasileiro em r??pida transforma????o, foi criado o espa??o institucional na, Escola de Governo em Sa??de (EGS), implantada na ENSP em 1998, dedicada a mobilizar e potencializar os esfor??os institucionais especificamente dirigidos a colaborar com a amplia????o da capacidade de governo em sa??de. Faremos uma breve exposi????o da forma????o de profissionais para a carreira de gest??o p??blica em alguns pa??ses das Am??ricas, mostrando a diversidade dos modelos de Escolas de Governo.

Exploring the interdisciplinary process in design education

The work presented herein follows an ongoing research that aims to analyze methodological practices to be applied in Design Education. A reflection about methodological strategies in Design Education and the function of drawing in Design represents the beginning of this study. Then, we developed an interdisciplinary pedagogical experience with the Graphic Design 1st grade students from our institution (IPCA). In the current academic year, 2013/2014, we continue to evolve this project, introducing changes in the initial proposal. Major alterations focused on the aspects that could be strengthened in terms of interdisciplinarity. In this article, the authors describe those changes and discuss the outcomes of the novel proposal. As we have already reported, this investigation follows a reflection about working methods to be adopted in Design Education. This is in accordance with other previously published works that purpose the enlargement of Design into new knowledge fields such as Experience or Service Design, changing not only the role of the graphic designer, but also the skills required to be a professional designer (Alain Findelli, 2001), (Brian Lawson, 2006), (Ciampa-Brewer, 2010). Furthermore, concepts such as cooperation or multidisciplinary design, amongst others, have been frequently debated as design teaching strategies (Heller and Talarico, 2011, pp. 82-85). These educational approaches also have an impact on our research. The analysis of all these authors’ contributions together with a reflection on our teaching practice allowed us to propose an improved interdisciplinary intervention.

RELATION BETWEEN BACKGROUND VARIABLES, VALUES AND CORPORATE SOCIAL RESPONSIBILITY

ABSTRACT Consumer perception of corporate social responsibility (CSR) can be directly influenced by individual value structures. This research aims to provide new knowledge regarding the relationship between basic human values and the public's perception of CSR. It focuses on the values of higher education students and their views regarding a particular corporate social initiative. The study reveals that social, educational, and economic circumstances influence human values. Those values in turn influence why different students perceive CSR differently. These findings are relevant to companies as they provide a more detailed understanding of why certain consumer groups perceive certain CSR initiatives the way that they do. They also suggest that universities should increase their awareness of the importance of integrating human values and CSR in the curricula of future business managers and social leaders.

Motivação dos trabalhadores na sociedade do conhecimento

RESUMO: Nas sociedades avançadas da actualidade, aqui denominadas por sociedades do conhecimento, os níveis de responsabilidade e de exigência mental das organizações para com os seus trabalhadores é superior a qualquer outra realidade anterior. É emergente a necessidade de redefinir a estrutura das organizações, para que os reponsáveis e os seus respectivos colaboradores usufruam de condições potenciadoras do seu desempenho profissional. Os perfis ideais dos responsáveis de equipas e , em especial, dos «novos» trabalhadores produtores de conhecimento, incorporam determinadas características fundamentais para favorecerem o processo criativo e o trabalho autónomo. Mas as alterações não estão confinadas à dimensão laboral, pois surgiram igualmente mudanças profundas no seio da sociedade, as quais obrigam à existência de uma nova relação entre a vida pessoal e a vida profissional dos cidadãos. Todas estas transformações resultam na necessidade de uma componente motivacional muito forte por parte dos trabalhadores, os quais dependem apenas de si mesmos para a conseguir obter e manter. A solução desta problemática surge aqui configurada sob a forma de uma mudança de atitude por parte de todos os trabalhadores, a qual deverá fomentar a ocorrência de «Experiências óptimas» provenientes do desenvolvimento da actividade profissional dos mesmos, tal como é sugerido pela Teoria do Fluxo. Esta versão profunda da motivação intrínseca e estável é proposta como modelar e mesmo fulcral para o trabalhador na Sociedade do conhecimento. ABSTRACT: In today’s advanced societies, here referred as Knowledge Societies, the levels of responsibility and mental demanding which organizations require from their workers is higher than ever before. The need to redefine organizations structures is now emerging in order to allow CEO’s and their co-workers having access to encouraging conditions which improve their work performance. The ideal profile for a team leader and especially for the «new» Knowledge production workers, incorporate a defined group of fundamental characteristics to encourage the creative process and the autonomous work. But changes are not confined to the labor dimension. The Society core also suffered profound changes which demand the existence of a new relation between personal and professional life of its citizens. All these changes create the need for the existence of high motivational levels inside all workers, which now have to find their own ways to get and maintain it. The solution for this problem is presented here as a switch in workers attitude, which will increase the occurrence of optimal experiences coming directly from the development of their professional activity like it’s suggested in the flow theory. This version of the deep intrinsic and stable motivation is proposed as a model or even a central solution to the worker in the Knowledge Society.

How can we help students to improve their creativity? – lessons learned from a case study

One of the main concerns of today’s organizations is to cope with the rapid pace of change while maintaining their competitive advantage. This means that firms must be innovative, create new knowledge and have new ideas constantly. Similarly, one of the main concerns of lecturers is to help students to develop creativity. According to some authors, new ideas, new thoughts, innovation can arise in an appropriate environment and with the development and train of adequate competences and skills. This means that although some persons were born more creative than others, it is possible to help those less creative to improve their innovative capacities and competences. The question that remains now is “how”. How can we, as lecturers and educators help our students to become more creative? In this paper we describe a Portuguese case study that took place at ISCAP (School of Accountancy and Administration of Porto – Portugal), in the course of Business Communication, in the unit “Marketing Communication” (3rd year (1st Bologna cycle), 1st semester). We will describe and characterize the situation at the beginning of the semester (situation A), explain the tasks and activities proposed to students and the final result (situation A2). We will discuss differences between situation A and A2, formulate some hypotheses concerning differences and draw some recommendations.

Technology for creativity and innovation: tools, techniques and applications

It is widely accepted that organizations and individuals must be innovative and continually create new knowledge and ideas to deal with rapid change. Innovation plays an important role in not only the development of new business, process and products, but also in competitiveness and success of any organization. Technology for Creativity and Innovation: Tools, Techniques and Applications provides empirical research findings and best practices on creativity and innovation in business, organizational, and social environments. It is written for educators, academics and professionals who want to improve their understanding of creativity and innovation as well as the role technology has in shaping this discipline.