Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells

The histone deacetylase inhibitors sodium butyrate (NaBu) and trichostatin A (TSA) exhibit anti-proliferative activity by causing cell cycle arrest and apoptosis. The mechanisms by which NaBu and TSA cause apoptosis and cell cycle arrest are not yet completely clarified, although these agents are known to modulate the expression of several genes including cell-cycle- and apoptosis-related genes. The enzymes involved in the process of translation have important roles in controlling cell growth and apoptosis, and several of these translation factors have been described as having a causal role in the development of cancer. The expression patterns of the translation mechanism, namely of the elongation factors eEF1A1 and eEF1A2, and of the termination factors eRF1 and eRF3, were studied in the breast cancer cell line MCF-7 by real-time quantitative reverse transcription-polymerase chain reaction after a 24-h treatment with NaBu and TSA. NaBu induced inhibition of translation factors' transcription, whereas TSA caused an increase in mRNA levels. Thus, these two agents may modulate the expression of translation factors through different pathways. We propose that the inhibition caused by NaBu may, in part, be responsible for the cell cycle arrest and apoptosis induced by this agent in MCF-7 cells.

Metabolic alterations in pregnant women: gestational diabetes

Gestational diabetes mellitus (GDM) and controversy are old friends. The impact of GDM on maternal and fetal health has been increasingly recognized. Nevertheless, universal consensus on the diagnostic methods and thresholds has long been lacking. Published guidelines from major societies differ significantly from one another, with recommendations ranging from aggressive screening to no routine screening at all. As a result, real-world practice is equally varied. This article recaps the latest evidence-based recommendations for the diagnosis and classification of GDM. It reviews the current evidence base for intensive multidisciplinary treatment of GDM and provides recommendations for postpartum management to delay and/or prevent progression to type 2 diabetes.

Fractional dynamics in liquid manipulation

This paper presents a fractional calculus perspective in the study of signals captured during the movement of a mechanical manipulator carrying a liquid container. In order to study the signals an experimental setup is implemented. The system acquires data from the sensors, in real time, and, in a second phase, processes them through an analysis package. The analysis package runs off-line and handles the recorded data. The results show that the Fourier spectrum of several signals presents a fractional behavior. The experimental study provides useful information that can assist in the design of a control system and the trajectory planning to be used in reducing or eliminating the effect of vibrations.

Schem@Doc: a web-based XML schema visualizer

XML Schema is one of the most used specifications for defining types of XML documents. It provides an extensive set of primitive data types, ways to extend and reuse definitions and an XML syntax that simplifies automatic manipulation. However, many features that make XML Schema Definitions (XSD) so interesting also make them rather cumbersome to read. Several tools to visualize and browse schema definitions have been proposed to cope with this issue. The novel approach proposed in this paper is to base XSD visualization and navigation on the XML document itself, using solely the web browser, without requiring a pre-processing step or an intermediate representation. We present the design and implementation of a web-based XML Schema browser called schem@Doc that operates over the XSD file itself. With this approach, XSD visualization is synchronized with the source file and always reflects its current state. This tool fits well in the schema development process and is easy to integrate in web repositories containing large numbers of XSD files.

Integration of repositories in Moodle

Current Learning Management Systems focus on the management of students, keeping track of their progress across all types of training activities. This type of systems lacks integration with other e-Learning systems. For instance, learning objects stored in a centralized repository are unavailable throughout an organization for potential reuse. In this paper we present the interoperability features of crimsonHex - a service oriented repository of learning objects - highlighting the use of XML languages. Its nteroperability features are compliant with the existing standards and we propose extensions to the IMS interoperability recommendation, adding new functions, formalizing an XML message interchange and providing also a REST interface. To validate the proposed extensions and its implementation in crimsonHex we designed two repository plugins for Moodle 2.0, the first of which is already implemented and is expected to be included in the next release of this popular learning management system.

Using device detection techniques in M-learning scenarios

Recent studies of mobile Web trends show the continued explosion of mobile-friend content. However, the wide number and heterogeneity of mobile devices poses several challenges for Web programmers, who want automatic delivery of context and adaptation of the content to mobile devices. Hence, the device detection phase assumes an important role in this process. In this chapter, the authors compare the most used approaches for mobile device detection. Based on this study, they present an architecture for detecting and delivering uniform m-Learning content to students in a Higher School. The authors focus mainly on the XML device capabilities repository and on the REST API Web Service for dealing with device data. In the former, the authors detail the respective capabilities schema and present a new caching approach. In the latter, they present an extension of the current API for dealing with it. Finally, the authors validate their approach by presenting the overall data and statistics collected through the Google Analytics service, in order to better understand the adherence to the mobile Web interface, its evolution over time, and the main weaknesses.

Rhapsody in Fractional

This paper studies several topics related with the concept of “fractional” that are not directly related with Fractional Calculus, but can help the reader in pursuit new research directions. We introduce the concept of non-integer positional number systems, fractional sums, fractional powers of a square matrix, tolerant computing and FracSets, negative probabilities, fractional delay discrete-time linear systems, and fractional Fourier transform.

XATA 2010 : XML : Associated Technologies and Applications, 8th

These are the proceedings for the eighth national conference on XML, its Associated Technologies and its Applications (XATA'2010). The paper selection resulted in 33% of papers accepted as full papers, and 33% of papers accepted as short papers. While these two types of papers were distinguish during the conference, and they had different talk duration, they all had the same limit of 12 pages. We are happy that the selected papers focus both aspects of the conference: XML technologies, and XML applications. In the first group we can include the articles on parsing and transformation technologies, like “Processing XML: a rewriting system approach", “Visual Programming of XSLT from examples", “A Refactoring Model for XML Documents", “A Performance based Approach for Processing Large XML Files in Multicore Machines", “XML to paper publishing with manual intervention" and “Parsing XML Documents in Java using Annotations". XML-core related papers are also available, focusing XML tools testing on “Test::XML::Generator: Generating XML for Unit Testing" and “XML Archive for Testing: a benchmark for GuessXQ". XML as the base for application development is also present, being discussed on different areas, like “Web Service for Interactive Products and Orders Configuration", “XML Description for Automata Manipulations", “Integration of repositories in Moodle", “XML, Annotations and Database: a Comparative Study of Metadata Definition Strategies for Frameworks", “CardioML: Integrating Personal Cardiac Information for Ubiquous Diagnosis and Analysis", “A Semantic Representation of Users Emotions when Watching Videos" and “Integrating SVG and SMIL in DAISY DTB production to enhance the contents accessibility in the Open Library for Higher Education". The wide spread of subjects makes us believe that for the time being XML is here to stay what enhances the importance of gathering this community to discuss related science and technology. Small conferences are traversing a bad period. Authors look for impact and numbers and only submit their works to big conferences sponsored by the right institutions. However the group of people behind this conference still believes that spaces like this should be preserved and maintained. This 8th gathering marks the beginning of a new cycle. We know who we are, what is our identity and we will keep working to preserve that. We hope the publication containing the works of this year's edition will catch the same attention and interest of the previous editions and above all that this publication helps in some other's work. Finally, we would like to thank all authors for their work and interest in the conference, and to the scientific committee members for their review work.

Traductor de especificaciones XML de redes de Petri coloreadas a un lenguaje para la resolución de problemas de optimización

Este proyecto presenta el desarrollo de una aplicación que permite traducir Redes de Petri Coloreadas diseñadas en CPN Tools a un lenguaje para la generación de ficheros de entrada a un simulador/optimizador de Redes de Petri Coloreadas. De esta manera se podrán optimizar modelos creados en CPN Tools ya que esta herramienta no facilita la optimización. Todo el proyecto se ha realizado en C++.

Generació de documents en application/pdf a partir d'una estructura XML

Aquesta memòria vol mostrar que la tecnologia XML és la millor alternativa per a afrontar el repte tecnològic existent en els sistemes d'extracció d'informació de les aplicacions de nova generació. Aquests sistemes, d'una banda, han de garantir la seva independència respecte dels esquemes de les bases de dades dels quals s'alimenten i, de l'altra, han de ser capaços de mostrar la informació en múltiples formats.

Estudi de com OWL amplia la funcionalitat d'RDF i aquest, a la seva vegada, d'XML

Aquest document explica com és aquesta web actual o sintàctica, basada en llenguatge HTML, i perquè no treu més profit de la ingent quantitat d'informació que conté. També explica d'una manera detallada quina és l'alternativa que la comunitat informàtica proposa per tal de superar aquests inconvenients.

Disseny i implementació d'un marc de treball de presentació amb XML per a aplicacions J2EE a partir del Framework Struts

L'objectiu principal d'aquest projecte és la separació total dels rols de programador i de dissenyador de vistes en el disseny d'aplicacions distribuïdes fetes mitjançant tecnologia J2EE, i també el suport d'una sola aplicació a diferents tipus de client i idiomes alhora, sense la necessitat de codi extra o específic per a aconseguir-ho.

Generació, actualització y consulta de bases de dades relacionals utilitzant XML (Servei d'emmagatzemament de dades a internet)

El que es vol, en aquest projecte, és generar una sèrie d'eines que permetin a una entitat externa d'interactuar en una base de dades relacional sense necessitat de coneixements específics sobre bases de dades. Quan es diu interactuar, s'hi inclou des de la creació de la base de dades fins a la consulta de la informació, passant per l'actualització d'aquesta base de dades.

XML i Web Semàntica

En aquest treball es realitza una descripció dels llenguatges que constitueixen la base de la construcció de la Web Semàntica: l'XML, l'RDF i l'OWL. En concret, es realitza un estudi de la base de dades lèxica WordNet. Finalment, es presenta el disseny i la implementació d'una ontologia per representar les relacions lèxiques dels mots del català. A partir d'aquesta ontologia es crea una petita base de dades basada en la temàtica dels animals de companyia. Aquest cas pràctic permet extreure conclusions sobre els avantatges d'introduir metadades en els documents electrònics, i sobre les facilitats que ofereixen les aplicacions actuals pel desenvolupament d'aquest tipus de documents.

Comparativa entre Xindice i eXist com a sistemes de bases de dades XML natives

Aquest TFC es basa en el desenvolupament d'un sistema informàtic que permeti fer cerques de persones dins una organització del tipus d'un institut de formació professional, en el qual s'imparteixin cicles formatius de grau mitjà i de grau superior, i batxillerat. La informació estarà desada en documents que incorporaran dades sobre els alumnes, els cursos i la relació que hi ha entre aquests alumnes i diferents organitzacions (per exemple, empreses on fan les seves pràctiques).