Long-term follow-up of follicular lymphoma (FL) patients receiving single agent rituximab at two different schedules in trial SAKK 35/98

Background: In FL, Rituximab as a single agent delivered in the standard schedule (4 times weekly) may induce a response rate of 50−70% with an event-free survival (EFS) of 1−3 years according to patients' characteristics. Prolonged Rituximab exposure seems to improve EFS at least in responding patients and to increase the rate of longterm responders. Here we report long-term results of a clinical trial comparing single agent Rituximab delivered in the standard schedule versus prolonged exposure, with focus on the proportion of long-term responders and their characteristics. Material and Methods: Between 1998 and 2002, chemotherapy na¨ıve (n = 64) or pre-treated (n = 138) FL patients received Rituximab in the standard schedule. Those responding or with stable disease were randomized to no further treatment (observation, n = 78) or 4 additional doses of Rituximab given at 2-month intervals (prolonged exposure, n = 73). EFS was calculated from the first dose of standard schedule until progression, relapse, second tumor or death. Results: At a median follow up of 9.4 years and with all living patients having been followed for at least 5 years, the median EFS is 13 months for the observation and 24 months for the prolonged exposure arm (p = 0.0007). In the observation arm 13% had no event at 5-years and only 4% at 8 years, while in the prolonged exposure arm it was 27% at 5 years and remained 21% at 8 years. The only significant prognostic factor for EFS in a multivariate Cox regression was the prolonged Rituximab schedule (hazard ratio 0.58, CI 0.39−0.86, p = 0.007), whereas being chemotherapy na¨ıve, presenting with stage

J2EE : simulador de IBEX 35

Este trabajo de final de carrera tiene como objetivo el diseño e implementación de un simulador de bolsa online donde los usuarios puedan realizar acciones de compra-venta de valores del mercado IBEX 35. Los beneficios obtenidos por cada usuario pasan a un listado de puntuaciones el cual mostrará qué usuarios han gestionado mejor sus inversiones.

[Phot. d'une planche reproduisant 35 costumes bretons par Le Michel, don du général Parmentier en 1880]

Donateur : Parmentier, Théodore (1821-1910)

IoWoman, January/February 2005, Vol.35, no.1

Newsletter for the Iowa Commission on the Status of Women

IoWoman, March/April 2005, Vol.35, no.2

Newsletter for the Iowa Commission on the Status of Women

IoWoman, May/June 2005, Vol.35, no.3

Newsletter for the Iowa Commission on the Status of Women

IoWoman, July/August 2005, Vol.35, no.4

Newsletter for the Iowa Commission on the Status of Women

IoWoman, September/October 2005, Vol.35, no.5

Newsletter for the Iowa Commission on the Status of Women

I-35 Corridor Trade Study Newsletter, Winter 1998

The Federal Highway Administration (FHWA)and the Departments of Transportation in Texas, Oklahoma, Kansas, Missouri, Iowa and Minnesota combined their efforts to conduct The I-35 Trade Corridor Study.

I-35 Corridor Trade Study - Final Executive Summary, 2005

The Federal Highway Administration (FHWA) and the Departments of Transportation in Texas, Oklahoma, Kansas, Missouri, Iowa and Minnesota combined their efforts to conduct a study of Interstate Highway 35 (I-35) from Laredo, Texas to Duluth, Minnesota. The purpose of the study was to assess the need for improved local, intrastate, interstate, and international service on I-35 and to clearly define a general feasible improvement plan to address those needs

I-35 Corridor Trade Study Newsletter, Fall 1999

The Federal Highway Administration (FHWA)and the Departments of Transportation in Texas, Oklahoma, Kansas, Missouri, Iowa and Minnesota combined their efforts to conduct The I-35 Trade Corridor Study.

I-35 Corridor Trade Study Newsletter, Spring 1999

The Federal Highway Administration (FHWA)and the Departments of Transportation in Texas, Oklahoma, Kansas, Missouri, Iowa and Minnesota combined their efforts to conduct The I-35 Trade Corridor Study.