New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Studio portrait of Mary (Miriam) Judey Portraits Women

Born Riga 1908, married to the chemist Ernst Mangold. They escaped the Nazis, hid in France and emigrated to the US in 1948

Mary (Miriam) Mangold nee Judey; Nice Portraits Women

Born Riga 1908, married to the chemist Ernst Mangold. They escaped the Nazis, hid in France and emigrated to the US in 1948

Caring for our Country: Burnett Mary Paddock Monitoring Program

Estimating the environment impacts of land management practice change on the Great Barrier Reef water quality.

Margarete Oppenheimer geb. Busch : 29. Mai 1883 - 8. August 1935.

Memorial book with the speeches by Leo Baeck and Hugo Jacobi.

Cyrus Adler papers, undated, 1883-1937.

Primarily correspondence relating to the Dropsie College for Hebrew and Cognate Learning, the Jewish encyclopedia, the Jewish Theological Seminary of America, the Smithsonian Institution and the American Jewish Historical Society. Contains also correspondence arranged alphabetically including letters from the staff of the American Hebrew, the American Jewish Committee, Theodor Herzl, the Jewish Agricultural and Industrial Aid Society, the Jewish Publication Society of America, Max J. Kohler, Louis Marshall, Jacob H. Schiff, Oscar S. Straus, Henrietta Szold, Stephen S. Wise and Israel Zangwill. Contains also material on the structure of the Jewish calendar, correspondence relating to the publication of the Jefferson Bible, correspondence and research material concerning Jewish servicemen in the Spanish-American War (published in the American Jewish year book, 1900-1901), a list of ... of the U.S. Congress, material ... immigration, the Jews in Rus ... cript proof articles from the Jewish quarterly review, numerous published articles by and ... Adler, and a large quantity of manuscript notes and material on Jewish history in general and American Jewish history in particular. Includes also David Sulzberger's collected data pertaining to the Jewish population in the United States-1900.

The business of myth-making: Mary Poppins, P.L. Travers and the Disney effect

In just one of the many extraordinary moments during the spectacular Opening Ceremony of the 2012 London Olympic Games, thirty Mary Poppinses floated into the stadium on their umbrellas to battle a 40 foot-long inflatable Lord Voldemort. This multi-million pound extravaganza was telecast to a global audience of over one billion people, highlighting in an extremely effective manner the grandeur and eccentricities of the host nation, and featuring uniquely British icons such as Mr Bean, James Bond, The Beatles and Harry Potter, as well as those quintessential icons of Englishness, the Royal Family, double-decker red buses and the National Health Service.

Nacionalidad e inmigración en el pensamiento de Estanislao Zeballos (1883-1912)

Resumen: Estanislao Zeballos (1854-1923), fue un prominente periodista, abogado y político argentino que publicó una serie de artículos y libros sobre varios temas relevantes: los indios araucanos, las colonias agrícolas de la provincia de Santa Fe, la cuestión del ius sanguinis-ius solis, y el impacto de la inmigración europea en la Argentina. Como otros hombres públicos contemporáneos de su país, Zeballos creía en el proyecto de una nueva nación construida por los inmigrantes. Sin embargo, sus preocupaciones giraron también en torno a los problemas que suponía una sociedad multicultural y los intentos por reconstruir un sentido de identidad nacional.

Redescription of Hypoptopoma inexspectata (Holmberg, 1883), with notes on its anatomy (Siluriformes: Loricariidae).

Hypoptopoma inexspectata is diagnosed and redescribed based on the examination of additional material and comparison with its congeners. This poorly known hypoptopomine species is distributed in the Paraguay and Paraná river draínages. Hypoptopoma inexspectata is diagnosable based on the autapomorphy biserial arrangement of anterior snout rostral margin odontodes, laterally extended to limit between second and third infraorbital plates, with dorsally directed dorsad series separated from ventrally directed ventrad series by a narrow odontode-free area, which at the level of first and second infraorbital plates is reduced to a dividing line of the series. The species can be further distinguished by the combination (1) low number of canal-bearing lateral plates (20-22, typically 21), (2) presence of a shield of prepectoral dermal plates, (3) arrangement of abdominal plates in one paired series of 3-5 plates, (4) shorter least interorbital distance 4856% head lengh, (5) larger horizontal eye diameter 17-20% head lengh, and (6) least orbit-nare distance 812% head lengh. Intraspecific variation skull dermal bones, neuracranium and suspensorium bones, dermal plates, adipose fin is reported. (PDF has 20 pages.)

Collecção das Leis do Imperio do Brazil de 1883

Parte 1 - Atos do Poder Legislativo