Association of microRNA 17–92 cluster host gene (MIR17HG) polymorphisms with breast cancer

Breast cancer incidence and mortality rates are increasing despite our current knowledge on the disease. Ninety-five percent of breast cancer cases correspond to sporadic forms of the disease and are believed to involve an interaction between environmental and genetic determinants. The microRNA 17–92 cluster host gene (MIR17HG) has been shown to regulate expression of genes involved in breast cancer development and progression. Study of single-nucleotide polymorphisms (SNPs) located in this cluster gene could help provide a further understanding of its role in breast cancer. Therefore, this study investigated six SNPs in the MIR17HG using two independent Australian Caucasian case–control populations (GRC-BC and GU-CCQ BB populations) to determine association to breast cancer susceptibility. Genotyping was undertaken using chip-based matrix assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry (MS). We found significant association between rs4824505 and breast cancer at the allelic level in both study cohorts (GRC-BC p = 0.01 and GU-CCQ BB p = 0.03). Furthermore, haplotypic analysis of results from our combined population determined a significant association between rs4824505/rs7336610 and breast cancer susceptibility (p = 5 × 10−4). Our study is the first to show that the A allele of rs4824505 and the AC haplotype of rs4824505/rs7336610 are associated with risk of breast cancer development. However, definitive validation of this finding requires larger cohorts or populations in different ethnical backgrounds. Finally, functional studies of these SNPs could provide a deeper understanding of the role that MIR17HG plays in the pathophysiology of breast cancer.

Burning of the Caroline (1840)

Message from the President of the United States, transmitting correspondence in relation to the burning of the steamboat Caroline.

Notes of proceedings and cases determined in the high court of errors and appeals, the court of chancery, and the orphans court of the state of Delaware, 1792-1832

Contains summaries of cases heard by the Delaware Supreme Court and the Delaware Appeals Court in the counties of Sussex, Kent, and Newcastle covering a variety of legal topics. Supposedly based on Wilson's Red Book.

Supplement to the Catalogue of the Library of Congress. December, 1840 [December, 1848.

None issued for 1841.

Opinions of the Supreme Court of Texas from 1840 to 1844 inclusive /

On leaf opposite title page: "These opinions were originally published at the back of a digest of laws. Therefore the paging began with number 357. As all subsequent decisions and digests refer to these cases b this original paging, it was thought best to retain it."

Young Ireland : a fragment of Irish history, 1840-45 /

University of Illinois Library bookplate on front paste-down: "From the collection of James Collins, Drumcondra, Ireland. Purchased, 1918."

Proceedings of a general court martial held at the Horse-Guards, on the 24th and 27th of March 1792 : for the trial of Capt. Richard Powell, Lieut. Christopher Seton, and Lieut. John Hall, of the 54th Regiment of Foot, on several charges preferred against them respectively by William Cobbett, late Serjeant-Major of the said regiment; together with several curious letters which passed between the said William Cobbett and Sir Charles Gould, Judge-Advocate General, and various other documents connected therewith in the order of their dates.

308C636no.195 #12.

Remarks upon Mr. Binney's letter, of January 3, 1840, to the presidents of the councils of the city of Philadelphia.

Letter of January 3 has title: A short letter to the councils of Philadelphia. cf. Sabin, Bibl. amer.

Remarks upon Mr. Binney's letter, of January 3, 1840, to the presidents of the councils of the city of Philadelphia.

Letter of January 3 has title: A short letter to the councils of Philadelphia. cf. Sabin, Bibl. amer.

A journal during a residence in France : from the beginning of August, to the middle of December, 1792, to which is added, an account of the most remarkable events that happened at Paris from that time to the death of the late king of France /

First edition, London, 1793-94.