Province of Upper Canada Grant to Abraham Cook

Province of Upper Canada Grant (vellum) to Abraham Cook of Williamsburg in the County of Dundas. He was the son of Michael Cook, a United Empire Loyalist. He is granted 200 acres in the Township of Nottawasaga in the County of Simcoe, lot no. 23 in the 3rd Concession – Folio 547, Sept. 14, 1836.

Letter to William Dickson of Galt from the cashier of the Bank of Upper Canada

Letter to William Dickson of Galt from the cashier of the Bank of Upper Canada, Toronto, Ontario. This letter informs Mr. Dickson that he has received a bonus on his shares of the Old Stock on the Bank of Upper Canada due to an act that was passed by legislature (3 pages, printed), Jan. 6, 1855.

Summons to Legislative Council of Upper Canada bestowed on William Dickson by George the Third, signed by the Attorney General

Summons to Legislative Council of Upper Canada bestowed on William Dickson by George the Third, signed by the Attorney General. The Crown Seal is faded, but intact, Nov. 16, 1815.

Province of Upper Canada Grant to the Honorable Peter Russell of the Township of Newark

Province of Upper Canada Grant to the Honorable Peter Russell of the Township of Newark. He is granted 150 acres in the Town of Newark in the County of Lincoln. This is registered in Liber B, folio 133. This was entered in the auditor’s office July 26, 1796. This document is held together with tape. The text is not affected, July 2, 1796.

Province of Upper Canada Grant (paper mounted on canvas) to the Honorable Peter Russell of the Township of Newark

Province of Upper Canada Grant (paper mounted on canvas) to the Honorable Peter Russell of the Township of Newark. He is granted 10 acres in the Township of Newark in the County of Lincoln. This document is mounted on canvas. This was entered in the auditor’s office Sept.29, 1797. Part of the paper document is missing but this does not affect the text, Sept. 1, 1797.

Province of Upper Canada Grant (paper mounted on canvas) to William Dickson

Province of Upper Canada Grant (paper mounted on canvas) to William Dickson. He is granted 24 acres with allowance for roads in the Town of Newark in the County of Lincoln. This was entered in the auditor’s office on June 12, 1798. Parts of the paper are missing. This affects the text slightly, Nov. 10, 1797.

Province of Upper Canada Grant (vellum) to Joseph Mills of the township of Grimsby

Province of Upper Canada Grant (vellum) to Joseph Mills of the township of Grimsby, son of United Empire Loyalist John Mills, United Empire Loyalist. He was granted 200 acres in the 5th Concession in Windham in the County of Norfolk. This was registered in in Liber L, folio 387 on Feb. 14, 1803. The crown land seal is attached, but broken into small pieces, Nov. 25, 1802.

Province of Upper Canada Grant (vellum) to Peter McCollum of the Township of Grimsby

Province of Upper Canada Grant (vellum) to Peter McCollum of the Township of Grimsby, son of James McCollum, United Empire Loyalist. He was granted 200 acres in Lot no.12 in the 5th Concession in the Township of Scott in the County of Yorke. This was entered with the auditor on Nov. 17, 1809. There is a partial crown land seal attached to this document but it is broken, Nov. 16, 1809.

Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA)

As the mean age of the global population increases, breast cancer in older individuals will be increasingly encountered in clinical practice. Management decisions should not be based on age alone. Establishing recommendations for management of older individuals with breast cancer is challenging because of very limited level 1 evidence in this heterogeneous population. In 2007, the International Society of Geriatric Oncology (SIOG) created a task force to provide evidence-based recommendations for the management of breast cancer in elderly individuals. In 2010, a multidisciplinary SIOG and European Society of Breast Cancer Specialists (EUSOMA) task force gathered to expand and update the 2007 recommendations. The recommendations were expanded to include geriatric assessment, competing causes of mortality, ductal carcinoma in situ, drug safety and compliance, patient preferences, barriers to treatment, and male breast cancer. Recommendations were updated for screening, primary endocrine therapy, surgery, radiotherapy, neoadjuvant and adjuvant systemic therapy, and metastatic breast cancer.

Late Pleistocene and Holocene paleoenvironments in ponds and alluvial sediments of Upper Paraná River, Brazil

Freshwater sponge spicules were analyzed as a paleoenvironmental proxy indicator in five cores of ponds and alluvial fan sediments in the Upper Paraná River's left bank, near Querência do Norte town, northwestern of State of Paraná, southern Brazil. Two optically stimulated luminescence (OSL) dates were obtained from sediments of ponds and one radiocarbon (14C) date was obtained from the alluvial fan. Microscopic analysis of spicules preserved in the sediments allowed a determination of freshwater sponge species. The species assemblage provides evidence for dominantly dry conditions in the Upper Paraná River during the Late Pleistocene. A wetter climate phase was recognized at 14C 7,540 yrs BP, with alluvial fan formation commencing at the transition of the dry Pleistocene climate to the Early Holocene wet climate. This wet interval was characterized by a sponge assemblage marked by the presence of the Neotropical families and typically associated with lotic environments. Sponge spicules analysis from pond sediments reject the possibility that lotic environments contributed to pond genesis and evolution. © 2013 by the Sociedade Brasileira de Paleontologia.

Research Training Program: Duke University and Brazilian Society of Cardiology

Background: Research coaching program focuses on the development of abilities and scientific reasoning. For health professionals, it may be useful to increase both the number and quality of projects and manuscripts. Objective: To evaluate the initial results and implementation methodology of the Research and Innovation Coaching Program of the Research on Research group of Duke University in the Brazilian Society of Cardiology. Methods: The program works on two bases: training and coaching. Training is done online and addresses contents on research ideas, literature search, scientific writing and statistics. After training, coaching favors the establishment of a collaboration between researchers and centers by means of a network of contacts. The present study describes the implementation and initial results in reference to the years 2011-2012. Results: In 2011, 24 centers received training, which consisted of online meetings, study and practice of the contents addressed. In January 2012, a new format was implemented with the objective of reaching more researchers. In six months, 52 researchers were allocated. In all, 20 manuscripts were published and 49 more were written and await submission and/or publication. Additionally, five research funding proposals have been elaborated. Conclusion: The number of manuscripts and funding proposals achieved the objectives initially proposed. However, the main results of this type of initiative should be measured in the long term, because the consolidation of the national production of high-quality research is a virtuous cycle that feeds itself back and expands over time. (Arq Bras Cardiol 2012;99(6):1075-1081)

Relationship between the logistic EuroSCORE and the Society of Thoracic Surgeons Predicted Risk of Mortality score in patients implanted with the CoreValve ReValving system--a Bern-Rotterdam Study

Background Surgical risk scores, such as the logistic EuroSCORE (LES) and Society of Thoracic Surgeons Predicted Risk of Mortality (STS) score, are commonly used to identify high-risk or “inoperable” patients for transcatheter aortic valve implantation (TAVI). In Europe, the LES plays an important role in selecting patients for implantation with the Medtronic CoreValve System. What is less clear, however, is the role of the STS score of these patients and the relationship between the LES and STS. Objective The purpose of this study is to examine the correlation between LES and STS scores and their performance characteristics in high-risk surgical patients implanted with the Medtronic CoreValve System. Methods All consecutive patients (n = 168) in whom a CoreValve bioprosthesis was implanted between November 2005 and June 2009 at 2 centers (Bern University Hospital, Bern, Switzerland, and Erasmus Medical Center, Rotterdam, The Netherlands) were included for analysis. Patient demographics were recorded in a prospective database. Logistic EuroSCORE and STS scores were calculated on a prospective and retrospective basis, respectively. Results Observed mortality was 11.1%. The mean LES was 3 times higher than the mean STS score (LES 20.2% ± 13.9% vs STS 6.7% ± 5.8%). Based on the various LES and STS cutoff values used in previous and ongoing TAVI trials, 53% of patients had an LES ≥15%, 16% had an STS ≥10%, and 40% had an LES ≥20% or STS ≥10%. Pearson correlation coefficient revealed a reasonable (moderate) linear relationship between the LES and STS scores, r = 0.58, P < .001. Although the STS score outperformed the LES, both models had suboptimal discriminatory power (c-statistic, 0.49 for LES and 0.69 for STS) and calibration. Conclusions Clinical judgment and the Heart Team concept should play a key role in selecting patients for TAVI, whereas currently available surgical risk score algorithms should be used to guide clinical decision making.

Cultural and Educational Society of Muslims "Narodna Uzdanica" /"National Hope"/ 1923-1941

Ibrahim Kemura. The Muslim Cultural-Educational Society Narodna uzdanica from 1923/4 to 1941 One of the features of the cultural history of the Bosniacs between the two world wars (1918-1941) was a cultural and educational society named Narodna uzdanica, which was a significant institutional and cultural-intellectual centre of the Bosniac people in Bosnia and Herzegovina. Narodna uzdanica expressed the aspirations and needs of the Bosniac citizens who were its main support and axis and was aimed at fulfilling their interests. This was reflected in an ideological-cultural orientation towards the West and the adoption of positive western achievements while at the same time stressing its Slavic origins and individuality, the education of young people and the formation of a European-type civic intelligentsia, adaptation to life in capitalist society, the development of modern trade and crafts, the emancipation of women, and cultural education based on European values. Thus conceived, the programme enjoyed the support of a wider circle of members, the reading public and the cultural consumers of those particular elements such as education and economic prosperity which it sought to achieve. The political involvement of Narodna uzdanica and its use as a platform for the leading Bosniac political party Jugoslovenska muslimanska organizacija (JMO - Yugoslav Muslim Organisation) which had founded the society, played a significant role in the socio-political life and development of Bosniacs. The opposition to the ruling regime, often expressed through close cooperation with similar Croat organisations and through the pro-Croat attitude of some of the society's leading figures, offered both the regime and Narodna uzdanica's political adversaries grounds for describing it as separatist and Croat and served as a pretext for repressive measures to hinder its normal operations. This research proved these accusations to be groundless, showing that the pro-Croat orientation was primarily political and cultural and that throughout its existence Narodna uzdanica was active in the cultural and educational renaissance of Bosniacs, helping to strengthen their national identity.

Sedimentological and geochemical characteristics of upper Cretaceous and lower Tertiary sediments of ODP Hole 108-661A

Based on sedimentological and geochemical data, the Upper Cretaceous and Tertiary sequence at Ocean Drilling Program Site 661 was subdivided into four intervals: Interval I (Campanian age) is characterized by sediments deposited below the calcite compensation depth (CCD) inside a high-productivity area and well-oxygenated bottom waters, indicated by the absence of carbonate, the major occurrence of zeolites and opal-CT, and intense bioturbation. Very fine-grained siliciclastic sediments and the lack of any erosional features suggest a low-energy environment. The terrigenous fraction was probably supplied by winds from the nontropical areas in South Africa. Interval II (Maestrichtian age) is characterized by high-amplitude variations in the carbonate content indicative of a deposition above the CCD, superimposed by (climate-controlled) short-term fluctuations of the CCD. The absence of both zeolites and opal-CT imply a position of Site 661 outside high-productivity areas. The first occurrence of higher amounts of kaolinite (especially during the middle Maestrichtian) suggests the onset of a terrigenous sediment supply from tropical areas. Interval III (between uppermost Cretaceous to early Tertiary) is characterized by the absence of carbonate and zeolites, interpreted as deposition below the CCD and outside an oceanic high-productivity belt. The kaolinite-over-illite dominance suggests a terrigenous sediment supply from tropical areas. Interval IV (between early Tertiary and Miocene age) is characterized by the occurrence of black manganeserich layers, major nodules/pebbles, and erosional surfaces, indicating phases of extremely reduced sediment accumulation and bottom-current activities. In the lower part of this interval (?Eocene age), higher amounts of zeolites occur, which suggest a higher oceanic productivity caused by equatorial upwelling. The source area of the terrigenous sediment fraction at Site 661 was the tropical region of northwest Africa, as suggested by the kaolinite-over-illite dominance.