Papel da proteína cinase C (PKC) no processamento de memórias aversivas e espaciais

Vários resultados na literatura fornecem fortes evidências de que o processamento de memórias requerem a participação da proteína cinase C (PKC) em estruturas sabidamente necessárias para este processamento, como o hipocampo, a amígdala basolateral (ABL) e o córtex parietal posterior (CPP). Neste trabalho mostramos que o inibidor seletivo das isoformas cálcio-dependentes da PKC, Go 6976, produz um efeito amnésico dosedependente sobre a consolidação de memória espacial de longa duração em ratos submetidos ao treino no labirinto aquático de Morris (LAM), quando infundido na região CA1 do hipocampo dorsal 15 minutos pré-treino, imediatamente pós-treino ou 15 minutos pré-teste para esta tarefa, sem alterar a atividade locomotora dos animais. Ainda na tarefa do LAM, o Go 6976 também apresentou este efeito amnésico sobre a reconsolidação de memórias espaciais de longa duração recentes e antigas, bem como sobre a consolidação da memória espacial de longa duração relativa ao treino reverso no LAM, mas não teve efeito sobre a memória espacial de curta duração nem sobre a extinção da memória espacial de longa duração. Já na tarefa de esquiva inibitória (EI) o Go 6976 produziu um efeito amnésico quando infundido na ABL imediatamente ou 30 minutos pós-treino, ou no CPP 270 ou 360 minutos pós-treino, enquanto o inibidor não-seletivo das isoformas da PKC, Go 7874, produziu os mesmos efeitos, exceto por, no CPP, causar amnésia quando infundido 180 ao invés de 270 minutos pós-treino. Estes resultados indicam que as PKCs, sobretudo as cálcio-dependentes, são importantes para o processamento de memórias espaciais e aversivas, apresentando na consolidação de memórias aversivas distintos tempos críticos de ativação em diferentes estruturas cerebrais, e sendo necessárias para a aquisição, consolidação, evocação e reconsolidação de memórias espaciais.

Narrativas do Brasil nas memórias de Pedro Nava

This thesis is a translation of work of the Brazilian doctor, Pedro da Silva Nava (1903-1984), in particular, his memoirs and chronicles, articulated with the writings of medicine history, aiming to defend that the autobiographical narratives are sources of research capable of promoting discussions on the expansion of the present at the confluence of complex and unequal society in constant changing process as the Brazilian. The theoretical and methodological support circulates around studies, proposals and thesis by Boaventura Santos about empowering past, destabilizing subjectivity, sociology of absences, cosmopolitan reason and translation work. The empirical support drawn from the literature produced by Nava were analyzed with reference this reasoning and studies that have facilitated the flow of translation among others, the studies of Antonio Candido, Arrigucci Jr., Boris Cyrulnik, Beatriz Sarlo, Ecléa Bosi, Ítalo Calvino, José Willington Germano, José Maria Cançado, Lev Vygotsky, Marilena Chauí, Paul Ricöeur and Walter Benjamim, without neglecting what we consider indispensable to scientific research, the production of relevant knowledge and prudent, in view of a decent life. The initial inflections reflect the subject of the Memoirs and its education/training, to then place the Memoir subject in the literary context, scientific, historical and Brazilian poetic (1972-2010), bringing great interpreters and discussing the rationale used by the Narrator that we defend stand closer to the cosmopolitan, showing the formation of narratives whose presence insert itself beforehand to modernist verve, linked to the discursive array against the literature as domination space, disseminated in Brazil in the early twentieth century. So, it articulate with those in which the concerns adjust the construction of the social formation of Brazil as a national heritage through literary narrative that focuses on a historical principle that becomes the past empowering, allowing his rereading, whose converge to memory, the lifestyles, the plurality of language and Brazilian culture, formed by several people, converging into a design not of culture but multiculturalism in Brazil. The memory issue was addressed in the space-time of experiences of being that narrates, shaped by a destabilizing subjectivity that sought to order the testimony of a time, a history and society, retelling them by creative imagination, almost fictional, to make circulate his knowledge about Brazil attached to his medical knowledge, as well as other subjects in his living group and other groups with whom they maintained contact. Thus, he portrayed both tangible and intangible cultural assets of the country as a form of preservation, giving them meanings and sense. It approaches, therefore, from the perspective of sociology of absences, the expansion of the present and by the logic inherent in his narratives of self and Brazil

Autoria e escrita: uma reflexão acerca do autorar em memórias de leituras de alunos de 9º ano do ensino fundamental

This paper presents results concerning studies conducted during the master's research in the area of Applied Linguistics of the Graduate Program in Language Studies - PPgEL, linked to the Federal University of Rio Grande do Norte. We approached this study the question of authorship, which has gained ground increasingly important in academic research, because the act of authoring, in view of the amount of circulating discourses socially, becomes increasingly questionable. We understand authorship as related to a positioning of the subject than to take responsibility, in the Bakhtinian sense, by its text, it makes their views, ideologies, beliefs and values, from ownership and restructuring of the speech of others. This research is methodologically inserted in a qualitative, interpretive in nature and has a corpus analysis of the ten productions written memoir genre of readings produced by students in 9th grade in elementary school. Research aimed to analyze the students' written productions held in the school environment, to identify these texts marks or evidence of authorship and investigate how the restructuring of ownership and voices of others in the process of authoring. We adopt a concept of language from bakhitinianas concepts and understand the text in a vision Geraldiana. The analyzes in this study showed that in most texts there is the strong presence of voices of others, either implicitly and/or explicit. That is, students, to build their sayings, if embraced the voices of others in various formats, in particular styles, namely, by what Bakhtin names as linear style and pictorial style. Some proved his statement highlighting their positions through direct quotes from authors of books, family, teachers, showing us that their voices are filled with voices of others with whom they approve, deny, analyze, think and reflect. We therefore conclude that students were constituted as subjects of their texts, authors, since they leave marked the voices of others so presentified and restructured voices of others who do not actually sounded like voices of others, but as present voices from a discursive restructuring producer

Infância - memórias: cenários - personas

Infância is undoubtedly memory, high qual ity l iterature, reputable, as the story moves between f ict ion and reality. Personal and social history, wi th such a sense of reality, causing the reader to prof it f rom the honesty and the sinceri ty producing, in this work, remarkable results in a constancy of cl ippings, f rame -by-f rame. Memory and obl ivion are this work guidance. We aim to denounce the relat ionship between the chi ld and violence, and as it is a memorialist ic text , we see the importance of f ict ion for this type of narrat ive to be sustained. I aim thereby show the tone of this report humanizing memories, its deep and decisive meaning, through the memories concepts by Le Gof f , by Seligmann-Silva and by Ecléa Bosi. I t is also through the theories of Jeanne Marie Ganegbin that I just ify the concept of remembering and forget t ing, and also it is also according the concepts of Eliane Zagury that I give support to the importance of autobiography as a a mean of expressing the reported memor ies. Final ly, in Infância, there is no room for fantasy. The lyricism that overwhelms, throughout each chapter, commands the author's imaginat ion. The need to invent gives way to the need to test ify, to denounce. And this t ransit ion occurs gradually, slow as Gra c il ia n o s c h i ld li f e , d u e to such humiliat ion and submission

Formação de professores de assentamentos rurais do Rio Grande do Norte: representações, memórias e práticas de letramento

This work has as study object the representations that teachers have about literacy, and schooling, as well as their memories and their reading and writing practices in the formation process of teachers in rural areas of the State of Rio Grande do Norte. We focused our discussion in literacy practices constructed on language workshops, assumed as necessary for the teacher formation, the existence of a pedagogical context that allows developing the appropriate teaching action. These workshops aimed at creating a space of constant reflection and action. The corpus is composed of letters written by teachers in formation workshops and interviews emphasizing questions of literacy, schooling, memories and reading and writing practices. These teachers make use of literacy practices related to the plots which they belong to. This research is informed mainly by studies that discuss the Literacy (Street, 1984, 1995; Barton, 1998; Freire, 1978, 1980, 1990, 1996), focusing its political character and of inclusion to the literate world, the Social Representations (Moscovici, 1978) and the studies on genre as a discoursive practice (Fairclough, 2001). Methodologically, this research is of critical ethnographic nature (Cameron, 1992). The letters are disclosed as identity practices - pictures of life histories of the teachers. The analyses of the interviews, in turn, show the literacy multifaceted character, evidencing innumerable views on the phenomenon

A construção da imagem de leitor em memórias de leitura

In this work, we analyzed reading memories of mother language teachers in continuing education context. Our objective was to understand how each individual has built his/her reader image. Our theoretical approach to the construction of selfimage was based on the concept of discursive ethos, understanding it with Charaudeau (2006) as something constructed in the intersection of glances (of the self and the other). To understand how each teacher has built his/her reader image in that intertwining of glances (of the self and the other) we are on the contributions of Bakhtin (2003, 2010b) on exotopic glance or distant/external glance. Therefore, in the analysis, we tried to capture the exotopic glance of the teachers about themselves in the various stages of their reader formation and from our exotopic look of researcher; we gave provisional finish of the reader image that teachers built of themselves. For the analysis, we adopted other theoretical assumptions: about genres, theme, composition and style, statement and social voices we based on Bakhtin (1997, 2003, 2010a, 2010b); on the notion of the discursive ethos we anchored in studies conducted by Maingueneau (2008a, 2008b); about reading, we adopted the theoretical references of Rojo (2005, 2008, 2009a, 2009b, 2009c, 2009d), Garcez (2002), Freire (2008) and Silva Neto (2007). For the discursive genre reading memories makes reference to the theme memory as well as is related to the context of teacher training, the study was supported in Aragão (1992) and Nóvoa`s (2007) theory. Situated in the area of Applied Linguistics, the research aligns with qualitative-interpretative approach of socio-historical basis. Finally, from the analysis of the corpus, data that emerged from the findings, we conclude by stating that readers have created images of themselves as active readers, readers interested in both readings, the ones respected and the ones unappreciated by the official culture

As memórias cortesãs de Olivier de La Marche : o nascimento do indivíduo e a espacialização da cortesia na escrita das Mémoires (1472-1501)

Cette dissertation propose l analyse des Mémoires de Olivier de La Marche, homme de la cour qui a vécu comme serviteur des maisons de Bourgogne et d Autriche de l année 1439 jusqu à 1502. Nous avons compris sa littérature comme particulière pour l époque, car elle est née motivé par les questions personnelles de l auteur. C est pourquoi qu elle s est éloignée des genres littéraires liés à la fonction de servir aux propos du prince, particulièrement les chroniques. Nous avons cru que ces intentions particulières ont eu l origine dans la tradition de la mémoire médiévale, qui a répandu de l oral pour l écrit pendant la fin de la Moyen Âge. Cette écriture de la mémoire, réglementée à l expérience de qui écrivait, a promu la naissance de l individu quand il a cherché assumer les lieux du personnage et du témoin des événements dans l espace du texte . Telle affirmation nous avons conduit jusqu à la fonction des discours qui ont créé des espaces dans l oeuvre. Motivé par la vision spécialisée comme maître d hôtel, tels discours ont produit un espace de la cour idéal, capable de justifier la personnalité de l auteur et de lui consacrer comme le maître de la pratique de la courtoisie

O estranho testamento de um vigário de província: as memórias de Jean Meslier

En 1762, Voltaire publie un petit livre intitulé Extraits des sentiments de Jean Meslier. Il s'agit d'um abregé des Mémoires de Jean Meslier qui circulaient comme littérature clandestine dans la première moitié du XVIIIe, siècle, sous forme de copies manuscrites. L'interêt de Voltaire pour ces Mémoires est compréhensible. Elles dénoncent toute religion comme imposture et fausseté et annoncent une philosophie matérialiste et athéiste. Quel rôle cet obscur vicaire de province aura exercé dans la constitution de la philosophie des lumières?

Sobredentadura inmediata y con carga tardía: Revisión de la literatura

The oral rehabilitation of the patients toothless totals presents large difficulties, because diverse factors act limiting the treatment with complete dentures conventional, as severe reabsorption of the alveolar process, generating for the phonetic patient difficulties and of mastication, annoyance, retention lack and stability of the prosthesis. With the emergence of you implant them osseointegratin idealized by Prof o Branemark, these aspects were improved by means of the possibility of new treatment options, as the overdentures tissue-implant-supported. However, the protocol of Branemark demanded a period of scaring from three to six months, owing the patients to await this time for the placement of the final prosthesis. This way, the surgical technique of immediate load was proposed to abbreviate this period, improving the transition phase, at the same time that it reduces the problems psychological associates. This way, the objective of the present study is to carry out a literature revision about the works that used overdentures comparing immediate and late load, the best alternative and factors wrapped in the success of the procedure discussing. © 2008 1995, Editorial Ciencias médicas.

Entre o doce e o amargo: cultura e revolução em Cuba nas memórias literárias de dois intelectuais exilados, Carlos Franqui e Guillermo Cabrera Infante (1951-1968)

Pós-graduação em História - FCLAS

Aspectos do realismo: em torno de Memórias de um sargento de milícias

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Mulher e negra: as memórias de Carolina Maria de Jesus e Maya Angelou

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Memórias Póstumas de Brás Cubas e a Consciência de Zeno: representações históricas das sociedades brasileira e italiana

Pós-graduação em Letras - IBILCE

Da utopia ao ceticismo: a sátira na literatura brasileira contemporânea

Pós-graduação em Estudos Literários - FCLAR

Da lama à ficção: memórias e diálogos da fome nos interstícios narrativos de homens e caranguejos

Homens e caranguejos (1967), única narrativa ficcional de Josué Apolônio de Castro (1908-1973), a priori publicada em francês (1966), durante o forçoso exílio do autor em Paris, é sumariamente expressiva desde o prólogo que antecede a trama. Nomeando as páginas introdutórias deste romance como Prefácio um tanto gordo para um romance um tanto magro, Josué de Castro distende, ao retomar num tempo que já considerava anacrônico, o hábito pela escrita prefacial, a concepção de paratexto ampliada por Gerard Genette (1930), em Palimpsestes (1982). Apresentando a fome pelas recordações infantis que dela possui, o autor aguça no público-leitor a vontade de tatear, rente a seu olhar aparentemente ingênuo de criança e, de ficcionista de “primeira viagem”, o macrocosmo de memórias da fome que lhe serve como porto de partida para a criação de um microcosmo lúdico e faminto, pelo qual a imaginação e impossibilidade de re-apresentação total do vivido na linguagem, rearranjam a realidade da condição humana, reinventando-a pela articulação dramática dos elementos formais, sobretudo, tempo-espaço, narrador e personagem. A ficção se põe no ritmo fragmentado de aventuras e desventuras assumidas a partir dos intervalos da memória. Serão sumários nos estudos mnemônicos, as apreciações de Henri Bergson em Matéria e memória (1896), Jacques Le Goff em História e memória (1924) e Maurice Halbwachs, na publicação póstuma de A memória coletiva (1950), em face de serem fontes subsidiárias da aproximação entre os estudos da memória e a literatura. Lança-se mão da lembrança a fim de legendar os diálogos futuros entre o protagonista infantil, João Paulo, ávido pela liberdade sonhadora própria da criança, e as memórias de outros experientes personagens, nem tão esperançosos assim. Dá-se na narrativa o tom que oscila entre a transformação e a acomodação do eu e do outro, de espaços simbioticamente incertos e unidos por suas fomes. Fome que é, desde então, a personagem modeladora, que provoca o diálogo da presente pesquisa com o modo de apreensão que é dado por Angela Faria, na dissertação Homens e caranguejos: uma trama interdisciplinar. A literatura topofílica e telúrica (2008). Vislumbra-se no elemento famélico uma função que vai além da tematização social do subdesenvolvimento, como agente que apalpa com mãos-de-ferro o estrato formal e interno da obra.