A continent revealed - The European Geotraverse - Link to Atlas of compiled data

The continent of Europe has a complex geological history of successive tectonic events. Over several thousand million years these have formed the present day configuration of major tectonic provinces. A Continent Revealed unravels this history by presenting and interpreting the results of the European Geotraverse (EGT) a unique study of the continent of Europe and the first comprehensive cross section of continental lithosphere. This illustrated book has been put together by key workers in the EGT project. It uses the wealth of information yielded by the ten years of experiments, study centres and workshops to provide a concise and thought provoking account of the geological processes that created the European continent. It provides a summary of the European Geotraverse, and at the same time a starting point for further work.

16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.

Previously, we have shown that agonists and antagonists interact with distinct, though overlapping regions within the human progesterone receptor (hPR) resulting in the formation of structurally different complexes. Thus, a link was established between the structure of a ligand-receptor complex and biological activity. In this study, we have utilized a series of in vitro assays with which to study hPR pharmacology and have identified a third class of hPR ligands that induce a receptor conformation which is distinct from that induced by agonists or antagonists. Importantly, when assayed on PR-responsive target genes these compounds were shown to exhibit partial agonist activity; an activity that was influenced by cell context. Thus, as has been shown previously for estrogen receptor, the overall structure of the ligand-receptor complex is influenced by the nature of the ligand. It appears, therefore, that the observed differences in the activity of some PR and estrogen receptor ligands reflect the ability of the cellular transcription machinery to discriminate between the structurally different complexes that result following ligand interaction. These data support the increasingly favored hypothesis that different ligands can interact with different regions within the hormone binding domains of steroid hormone receptors resulting in different biologies.