5-HT1A, but not 5-HT2 and 5-HT7, receptors in the nucleus raphe magnus modulate hypoxia-induced hyperpnoea

Aim: In the present study, we assessed the role of 5-hydroxytryptamine (5-HT) receptors (5-HT1A, 5-HT2 and 5-HT7) in the nucleus raphe magnus (NRM) on the ventilatory and thermoregulatory responses to hypoxia.Methods: To this end, pulmonary ventilation (V-E) and body temperature (T-b) of male Wistar rats were measured in conscious rats, before and after a 0.1 mu L microinjection of WAY-100635 (5-HT1A receptor antagonist, 3 mu g 0.1 mu L-1, 56 mM), ketanserin (5-HT2 receptor antagonist, 2 mu g 0.1 mu L-1, 36 mM) and SB269970 (5-HT7 receptor antagonist, 4 mu g 0.1 mu L-1, 103 mM) into the NRM, followed by 60 min of severe hypoxia exposure (7% O-2).Results: Intra-NMR microinjection of vehicle (control rats) or 5-HT antagonists did not affect V-E or T-b during normoxic conditions. Exposure of rats to 7% O-2 evoked a typical hypoxia-induced anapyrexia after vehicle microinjections, which was not affected by microinjection of WAY-100635, SB269970 or ketanserin. The hypoxia-induced hyperpnoea was not affected by SB269970 and ketanserin intra-NMR. However, the treatment with WAY-100635 intra-NRM attenuated the hypoxia-induced hyperpnoea.Conclusion: These data suggest that 5-HT acting on 5-HT1A receptors in the NRM increases the hypoxic ventilatory response.

Reconstruction of the medial patellofemoral ligament using the adductor magnus tendon: an anatomic study

The aims of this study were to evaluate the anatomic feasibility of medial patellofemoral ligament (MPFL) reconstruction using a part of the adductor magnus tendon and to identify possible risks.

Sir Philipp Magnus [Illustration] : (Porträt)

Scan von Monochrom-Mikroform

Prof. Paul Magnus [Illustration] : (Porträt)

Scan von Monochrom-Mikroform

Graf Magnus Gabriel de la Gardie [Illustration] : (Porträt)

Abraham Alexander Cooper

Hawdoloh und Zapfenstreich : Erinnerungen an die ostjüdische Etappe 1916 - 1918. Mit Zeichnungen von Magnus Zeller

Titelbl. gestempelt: Dr. Alfons Paquet

Bremer Gärten im Winter : 1. St. Magnus

von L. Wittmack

Albertus Magnus mit des Königs Tochter auß Franckreich : in des Marners Gulden thon

In Fraktur

Désiré Magnus, Hüftbild

Signatur des Originals: S 36/F01168

Magnus Deutz, Kniestück

Signatur des Originals: S 36/G04198

Praktische bedürfnisse und die rezeption der aristotelischen «Politik» im 13. und 14. Jahrhundert, Das Beispiel des Albertus Magnus

Fil: Miethke, Jürgen. Universidad de Heidelberg