A role for Cdc42 in macrophage chemotaxis

Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1.2F5 macrophages, we have shown that Rho regulates cell contraction, whereas Rac and Cdc42 regulate the formation of lamellipodia and filopodia, respectively. We have now tested the roles of Cdc42, Rac, and Rho in colony stimulating factor-1 (CSF-1)-induced macrophage migration and chemotaxis using the Dunn chemotaxis chamber. Microinjection of constitutively activated RhoA, Rac1, or Cdc42 inhibited cell migration, presumably because the cells were unable to polarize significantly in response to CSF-1. Both Rho and Rac were required for CSF-1-induced migration, since migration speed was reduced to background levels in cells injected with C3 transferase, an inhibitor of Rho, or with the dominant-negative Rac mutant, N17Rac1. In contrast, cells injected with the dominant-negative Cdc42 mutant, N17Cdc42, were able to migrate but did not polarize in the direction of the gradient, and chemotaxis towards CSF-1 was abolished.

Woodruff Family fonds, 1784 – 1983, (non-inclusive)

The Woodruff Family Collection: From the time the Woodruff Family came to Canada from the United States in 1795, they took an active role in the forming of their communities both in a civic and social manner. This is evident through the documents contained in this collection. The Woodruffs played an active role in the battles fought in Upper Canada and they were an integral part of the Village of St. Davids. They were educated, business-minded and socially engaged. They accumulated much of their fortune through land dealings. Much of this collection focuses on Samuel DeVeaux Woodruff who was principally a businessman. His dedication to his work is shown through his numerous undertakings. He made his mark on the Niagara Peninsula through his work on the railways, roads, marsh land revisions, canals and the paper industry. He was also involved with the founding of the Long Point Company and he took control of building DeVeaux Hall down to the last detail. His offspring inherited his work ethic and his business acumen. The people who married into the Woodruff Family also possessed key social, political and business ties. Anne and Margaret Clement were from a staunch Loyalist background. Samuel Zimmerman was instrumental to the founding of Niagara Falls and Judge Samuel DeVeaux left behind a legacy for poor and homeless boys in Niagara Falls, New York. The Woodruff Family undoubtedly left a mark on the Niagara Peninsula. This collection brings to light many endeavours of the family and their varied contributions.

The Goss-Udderzook tragedy : being a history of a strange case of deception and murder, including the great life insurance case, and the trial of William E. Udderzook for the murder of W. S. Goss.

Spine title: Trial of Udderzook.

The life of Sir William Wallace, the governor general of Scotland, and hero of the Scottish chiefs, Containing his parentage, adventures, heroic achievements, imprisonments and death; drawn from authentic materials of Scottish history.

Mode of access: Internet.

The Hord family of Virginia; a supplement to the Genealogy of the Hord family,

Photocopy.

William J. Browning (late a representative from New Jersey) : memorial addresses delivered in the House ... and Senate of the U.S., 66th Congress, 2nd session.

Mode of access: Internet.

Some of the descendants of Zaccheus Ballord : a private in the revolutionary war; also in the last French and Indian war.

Mode of access: Internet.

A chronicle of England during the reigns of the Tudors, from A.D. 1485 to 1559. By Charles Wriothesley, Windsor Herald. Ed., from a ms. in the possession of Lieut.-General Lord Henry H.M. Percy ...

Mode of access: Internet.

The register of John de Halton, bishop of Carlisle, A.D. 1292-1324.

Issued in 4 parts, 1906-13.

The Lindsays of America. A genealogical narrative, and family record beginning with the family of the earliest settler in the mother state, Virginia, and including in an appendix all the Lindsays of America.

Blank pages at end: Family record and additions.

The life, surprising adventures, and heroic actions of Sir William Wallace, general and governor of Scotland.

"This history of Sir William Wallace, with the other of the valiant King Robert Bruce, which followeth upon the end of it [not in UCLA copy] ... [was] written in Latin by Mr. John Blair, chaplain to Wallace, and turned into Scots metre by one called Blind Hary, in the days of King James IV, the other [was] written by Mr. John Barbour". - Introduction.

John Walker Maury; his lineage and life. A sketch

Mode of access: Internet.