Business under the new price laws; a study of the economic and legal problems arising out of the Robinson-Patman Act and the various fair trade and unfair practices laws,

"Table of cases": p. [441]-447.

Sibirʹ.

Mode of access: Internet.

Kochevaiï¸ a︡ zhiznʹ v Sibiri /

Mode of access: Internet.

The old-spelling Shakespeare: being the works of Shakespeare in the spelling of the best quarto and folio texts;

Issued also with imprint: New York, Duffield & company; London, Chatto and Windus.

Mr. Oseba's last discovery.

Mode of access: Internet.

Laboratory manual of elementary organic chemistry

Mode of access: Internet.

Skeletal muscle and nuclear hormone receptors: Implications for cardiovascular and metabolic disease

Skeletal muscle is a major mass peripheral tissue that accounts for similar to 40% of the total body mass and a major player in energy balance. It accounts for > 30% of energy expenditure, is the primary tissue of insulin stimulated glucose uptake, disposal, and storage. Furthermore, it influences metabolism via modulation of circulating and stored lipid (and cholesterol) flux. Lipid catabolism supplies up to 70% of the energy requirements for resting muscle. However, initial aerobic exercise utilizes stored muscle glycogen but as exercise continues, glucose and stored muscle triglycerides become important energy substrates. Endurance exercise increasingly depends on fatty acid oxidation (and lipid mobilization from other tissues). This underscores the importance of lipid and glucose utilization as an energy source in muscle. Consequently skeletal muscle has a significant role in insulin sensitivity, the blood lipid profile, and obesity. Moreover, caloric excess, obesity and physical inactivity lead to skeletal muscle insulin resistance, a risk factor for the development of type II diabetes. In this context skeletal muscle is an important therapeutic target in the battle against cardiovascular disease, the worlds most serious public health threat. Major risk factors for cardiovascular disease include dyslipidemia, hypertension, obesity, sedentary lifestyle, and diabetes. These risk factors are directly influenced by diet, metabolism and physical activity. Metabolism is largely regulated by nuclear hormone receptors which function as hormone regulated transcription factors that bind DNA and mediate the pathophysiological regulation of gene expression. Metabolism and activity, which directly influence cardiovascular disease risk factors, are primarily driven by skeletal muscle. Recently, many nuclear receptors expressed in skeletal muscle have been shown to improve glucose tolerance, insulin resistance, and dyslipidernia. Skeletal muscle and nuclear receptors are rapidly emerging as critical targets in the battle against cardiovascular disease risk factors. Understanding the function of nuclear receptors in skeletal muscle has enormous pharmacological utility for the treatment of cardiovascular disease. This review focuses on the molecular regulation of metabolism by nuclear receptors in skeletal muscle in the context of dyslipidemia and cardiovascular disease. (c) 2005 Published by Elsevier Ltd.

TRAP220 is modulated by the antineoplastic agent 6-Mercaptopurine, and mediates the activation of the NR4A subgroup of nuclear receptors

The NR4A1-3 (Nur77, NURR1 and NOR-1) subfamily of nuclear hormone receptors (NRs) has been implicated in Parkinson's disease, schizophrenia, manic depression, atherogenesis, Alzheimer's disease, rheumatoid arthritis, cancer and apoptosis. This has driven investigations into the mechanism of action, and the identification of small molecule regulators, that may provide the platform for pharmaceutical and therapeutic exploitation. Recently, we found that the purine antimetabolite 6-Mercaptopurine (6-MP), which is widely used as an anti-neoplastic and anti-inflammatory drug, modulated the NR4A1-3 subfamily. Interestingly, the agonist-mediated activation did not involve modulation of primary coactivators' (e.g. p300 and SRC-2/GRIP-1) activity and/or recruitment. However, the role of the subsequently recruited coactivators, for example CARM-1 and TRAP220, in 6-MP-mediated activation of the NR4A1-3 subfamily remains obscure. In this study we demonstrate that 6-MP modulates the activity of the coactivator TRAP220 in a dose-dependent manner. Moreover, we demonstrate that TRAP220 potentiates NOR-1-mediated transactivation, and interacts with the NR4A1-3 subgroup in an AF-1-dependent manner in a cellular context. The region of TRAP220 that mediated 6-MP activation and NR4A interaction was delimited to amino acids 1-800, and operates independently of the critical PKC and PKA phosphorylation sites. Interestingly, TRAP220 expression does not increase the relative induction by 6-MP, however the absolute level of NOR-1-mediated trans-activation is increased. This study demonstrates that 6-MP modulates the activity of the NR4A subgroup, and the coactivator TRAP220.

Birds of the Crane Pacific expedition, by Ernst Mayr and Sidney Camras.

v.20:no.34(1938)

EGA : 2003 eta 2004 : azterketak eta erantzunak. 'EGA : 2003 y 2004 : examenes y respuestas'.

Resumen tomado de la web del Departamento de Educación

List of New Guinea birds; a systematic and faunal list of the birds of New Guinea and adjacent islands.

Mode of access: Internet.

Birds of the southwest Pacific, a field guide to the birds of the area between Samoa, New Caledonia, and Micronesia,

Mode of access: Internet.

Análisis de la política exterior de defensa y seguridad de los Estados Unidos de América a partir del realismo hegemónico, durante el segundo gobierno (2005-2009) de George W. Bush, en el Plan Colombia

En esta monografía se analiza la influencia de la política exterior de los Estados Unidos de América hacia Colombia, desde la teoría del Realismo Hegemonico de Joseph Nye, y se busca mostrar por medio de noticias el poder duro y el poder blando que ejecer EUA hacia Colombia. Además se busca demostrar como esta teoría se ve reflejada en el Plan Colombia, por ultimo se busca advetir el peligro que puede llegar a ser el poder blando para el Sistema Internacional.