Politics, Patriotism and Women in Ireland, Britain and Colonial America, c.1700-c.1780

The use of the consumer boycott as a political tool is commonly associated with pre-revolutionary colonial America and has been identified by historians as an important means through which American women were politicized. This article argues that from the late seventeenth century, Irish political discourse advocated the non-consumption of imported goods and support for home manufactures by women in ways that were strikingly similar to those used later in North America. In Ireland and, subsequently in the American colonies, the virtuous woman consumer was given an active public role by political and social commentators. Rather than being a “brilliantly original American invention,” as T. H. Breen has argued, the political exploitation of a consumer boycott and the promotion of local industry were among what Bernard Bailyn has described as the “set of ideas, already in scattered ways familiar” to the revolutionary leaders through the Irish experience. The article also argues that a shared colonial environment gave Irish and American women a public patriotic role in the period, c. 1700–1780 that they did not have in the home countries of England and Scotland.

The Potential of Antimicrobial Peptides as Biocides

Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial molecules which have activity against a wide range of pathogenic microorganisms. Antimicrobial peptides are exciting leads in the development of novel biocidal agents at a time when classical antibiotics are under intense pressure from emerging resistance, and the global industry in antibiotic research and development stagnates. This review will examine the potential of antimicrobial peptides, both natural and synthetic, as novel biocidal agents in the battle against multi-drug resistant pathogen infections.

Binding modes of diketo-acid inhibitors of HIV-1 integrase: A comparative molecular dynamics simulation study

HIV-1 integrase (IN) has become an attractive target since drug resistance against HIV-1 reverse transcriptase (RT) and protease (PR) has appeared. Diketo acid (DKA) inhibitors are potent and selective inhibitors of HIV-1 IN: however the action mechanism is not well understood. Here, to study the inhibition mechanism of DKAs we performed 10 ns comparative molecular dynamics simulations on HIV-1 IN bound with three most representative DMA inhibitors: Shionogi inhibitor, S-1360 and two Merck inhibitors L-731,988 and L-708,906. Our simulations show that the acidic part of S-1360 formed salt bridge and cation-pi interactions with Lys159. In addition, the catalytic Glu152 in S-1360 was pushed away from the active site to form an ion-pair interaction with Arg199. The Merck inhibitors can maintain either one or both of these ion-pair interaction features. The difference in potencies of the DMA inhibitors is thus attributed to the different binding modes at the catalytic site. Such structural information at atomic level, not only demonstrates the action modes of DMA inhibitors but also provides a novel starting point for structural-based design of HIV-1 IN inhibitors.

Exchange systems and style in the Central Mediterranean. 4500-1700 b.c..:Unpublished PhD. Cambridge University Library

Malone, C.A.T., 1986, Unpublished PhD, Cambridge University, Cambridge.

Shakespeare in Performance, 1700 to the Present

A long essay (20,000) on the history of Shakespeare in performance worldwide, from 1700 to the present. The essay forms part of the critical introduction to the Bankside Shakespeare, successor to the Riverside Shakespeare, the world's best-selling single-volume edition of the plays of Shakespeare. I am also a Contributing Editor to this volume.

O jogo do desejo: retórica e comunicação amorosas na obra de Claude Crébillon

Tese de doutoramento, Literatura Francesa, Unidade de Ciências Humanas e Sociais, Universidade do Algarve, 2000

Letter, to Colonel Calvin Spencer, Chesterfield, SC, c. 1700 October

This letter is from E. Waterman to Colonel Calvin Spencer.

La Terre sainte, royaume de Marie : journal bi-mensuel / Oeuvre religieuse de l'Orient ; [dir. Claude-Régis Girard]

1875/05/20 (A11,N9)- (A11,N10).

La Terre sainte, royaume de Marie : journal bi-mensuel / Oeuvre religieuse de l'Orient ; [dir. Claude-Régis Girard]

1875/02/20 (A11,N3)- (A11,N4).

La Terre sainte, royaume de Marie : journal bi-mensuel / Oeuvre religieuse de l'Orient ; [dir. Claude-Régis Girard]

1875/04/30 (A11,N7)- (A11,N8).