ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults

© 2015 John Wiley & Sons Ltd.

Hepatic IGF1 DNA methylation is influenced by gender but not by intrauterine growth restriction in the young lamb

Acknowledgements: The authors would like to thank Chaz Mein and Eva Wozniak at the Genome Centre, Queen Mary University of London, who were integral to the development of the DNA methylation assays and processing of samples. Financial Support: This work was supported by Wellbeing of Women (D.J.C., grant number RTF318) and the Scottish Government’s Rural and Environment Science and Analytical Services Division including the Strategic Partnership for Animal Science Excellence (J.M.W., R.P.A., J.S.M. and C.L.A.).

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

Estrogen regulates hippocampal dendritic spine density and synapse number in an N-methyl-d-aspartate (NMDA) receptor-dependent manner, and these effects may be of particular importance in the context of age-related changes in endocrine status. We investigated estrogen's effects on axospinous synapse density and the synaptic distribution of the NMDA receptor subunit, NR1, within the context of aging. Although estrogen induced an increase in axospinous synapse density in young animals, it did not alter the synaptic representation of NR1, in that the amount of NR1 per synapse was equivalent across groups. Estrogen replacement in aged female rats failed to increase axospinous synapse density; however, estrogen up-regulated synaptic NR1 compared with aged animals with no estrogen. Therefore, the young and aged hippocampi react differently to estrogen replacement, with the aged animals unable to mount a plasticity response generating additional synapses, yet responsive to estrogen with respect to additional NMDA receptor content per synapse. These findings have important implications for estrogen replacement therapy in the context of aging.

A catalogue of pictures by British artists, in the possession of Sir John Fleming Leicester, bart., with etchings from the whole collection. Including the pictures in his gallery at Tabley House, Cheshire; executed by permission of the proprietor; and accompanied with historical and biographical notices.

Mode of access: Internet.

Plain catechetical instruction for young communicants, designed to assist them in forming Scriptural views of the Lord's Supper. With an address to young persons not yet communicants, and a few meditations and helps for self-examination.

Mode of access: Internet.

A sacramental catechism; or a familiar instructor for young communicants ... Revised from the Glasgow edition of 1794.

Mode of access: Internet.

Hospitable England in the seventies : the diary of a young American, 1875-1876 /

Mode of access: Internet.

Rudimental lessons in etymology and syntax : in which these two parts of grammar are exhibited in parallel columns : carelfuly [sic] adapted to the capacity of young learners. : Chiefly selected from Murray's grammar. /

Table of contents on last p.

Select exercises for young proficients in the mathematicks ... /

Mode of access: Internet.

Clarissa or, The history of a young lady ... : vol. VI.

Mode of access: Internet.

Clarissa or, The history of a young lady ... : vol. VII.

Mode of access: Internet.