980 resultados para ICF-CY


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The accurate computation of radioactive opacities is needed in several research fields such as astrophysics, magnetic fusion or ICF target physics analysis, in which the radiation transport is an important feature to determine in detail. Radiation transport plays an important role in the transport of energy in dense plasma and it is strongly influenced by the variation of plasma opacity with density and temperature, as well as, photon energy. In this work we present some new features of the opacity code ATMED [1]. This code has been designed to compute the spectral radioactive opacity as well as the Rosseland and Planck means for single element and mixture plasmas. The model presented is fast, stable and reasonably accurate into its range of application and it can be a useful tool to simulate ICF experiments in plasma laboratory.

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The Atomic Physics Group at the Institute of Nuclear Fusion (DENIM) in Spain has accumulated experience over the years in developing a collection of computational models and tools for determining some relevant microscopic properties of, mainly, ICF and laser-produced plasmas in a variety of conditions. In this work several applications of those models in determining some relevant microscopic properties are presented.

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DNA methylation is an important regulator of genetic information in species ranging from bacteria to humans. DNA methylation appears to be critical for mammalian development because mice nullizygous for a targeted disruption of the DNMT1 DNA methyltransferase die at an early embryonic stage. No DNA methyltransferase mutations have been reported in humans until now. We describe here the first example of naturally occurring mutations in a mammalian DNA methyltransferase gene. These mutations occur in patients with a rare autosomal recessive disorder, which is termed the ICF syndrome, for immunodeficiency, centromeric instability, and facial anomalies. Centromeric instability of chromosomes 1, 9, and 16 is associated with abnormal hypomethylation of CpG sites in their pericentromeric satellite regions. We are able to complement this hypomethylation defect by somatic cell fusion to Chinese hamster ovary cells, suggesting that the ICF gene is conserved in the hamster and promotes de novo methylation. ICF has been localized to a 9-centimorgan region of chromosome 20 by homozygosity mapping. By searching for homologies to known DNA methyltransferases, we identified a genomic sequence in the ICF region that contains the homologue of the mouse Dnmt3b methyltransferase gene. Using the human sequence to screen ICF kindreds, we discovered mutations in four patients from three families. Mutations include two missense substitutions and a 3-aa insertion resulting from the creation of a novel 3′ splice acceptor. None of the mutations were found in over 200 normal chromosomes. We conclude that mutations in the DNMT3B are responsible for the ICF syndrome.

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"Written by an anonymous Celestine monk in the 1470s at Notre Dame D'Ambert near Orleans ... an interesting example of devotional literature in the vernacular written by the Celestines for women. The complicated story behind this text (which survives in only two manuscripts), however, is even more interesting, since its source is the Miroir des simples âmes (Mirror of Simple Souls) by the mystical writer, Marguerite Porete, who was burnt at the stake as a relapsed heretic in Paris in 1310"--Textmanuscripts.com

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Includes bibliographical references.

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