Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.

B cells with a rearranged heavy-chain variable region VHa allotype-encoding VH1 gene segment predominate throughout the life of normal rabbits and appear to be the source of the majority of serum immunoglobulins, which thus bear VHa allotypes. The functional role(s) of these VH framework region (FR) allotypic structures has not been defined. We show here that B cells expressing surface immunoglobulin with VHa2 allotypic specificities are preferentially expanded and positively selected in the appendix of young rabbits. By flow cytometry, a higher proportion of a2+ B cells were progressing through the cell cycle (S/G2/M) compared to a2- B cells, most of which were in the G1/G0 phase of the cell cycle. The majority of appendix B cells in dark zones of germinal centers of normal 6-week-old rabbits were proliferating and very little apoptosis were observed. In contrast, in 6-week-old VH-mutant ali/ali rabbits, little cell proliferation and extensive apoptosis were observed. Nonetheless even in the absence of VH1, B cells with a2-like surface immunoglobulin had developed and expanded in the appendix of 11-week-old mutants. The numbers and tissue localization of B cells undergoing apoptosis then appeared similar to those found in 6-week-old normal appendix. Thus, B cells with immunoglobulin receptors lacking the VHa2 allotypic structures were less likely to undergo clonal expansion and maturation. These data suggest that "positive" selection of B lymphocytes through FR1 and FR3 VHa allotypic structures occurs during their development in the appendix.

Ḥab��b-i siyar jild al-thānī, [1026, i.e. 1617].

This is the second of three volumes which comprise Khvandemīr's well known and important general history, completed in 929/1523, which spans the creation of the world up to the death of Shah Ismāʻīl Safavī I. The work includes particularly detailed information about Herat under Sultan Husayn Bayqara, the last Timurid ruler in Herat, as well as Shah Ismāʻīl and B��bur's life. This work has been published in both Persian and English editions.

Hādhā huwa Kitāb al-tawḥīd /

Risālat al-iʻtiqādāt, by Muḥammad Bāqir Majlisī: p. 480-519.

Hādhā Kitāb Raḥīq al-kawthar min kalām al-Ghawth al-Rifāʻī al-akbar [microform] /

Microfilm.

Hādhā kitāb Khaṣāʼiṣ al-Ḥusayn wa-mazāyā al-maẓlūm [microform] /

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Hādhā kitāb Khaṣāʼiṣ al-Ḥusayn wa-mazāyā al-maẓlūm [microform] /

Caption title.

Hādhā Kitāb Manāṭ al-aḥkām [microform] /

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Hādhā huwa al-kitāb al-musammá bi-al-Mabdaʼ wa-al-maʻād al-mushtamil ʻalá fannayn fann fī al-rubūbīyat wa-fann fī ʻilm al-nafs [microform] /

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Hādhā Kitāb al-Lumʻah al-bayḍāʼ fī sharḥ khuṭbat al-Zahrāʼ[microform]

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al-Juzʾ al-awwal[-al-rābiʻ] min Tafsīr Qurʾān al-jalīl al-musammá Lubāb al-taʾwīl fī maʻānī al-tanzīl [microform] /

Microfilm.

Kitāb Ḥusn al-tawassul fī al-nahār wa-al-layl : sharḥ ṣalāt al-Shaykh Shamūyil /

Özege, M. S., Eski harflerle,

A biographical sketch of Sardar Mir Abdul Ali ... head of the detective police, Bombay. With an account of interesting criminal cases.

Mode of access: Internet.

Hādhā kitāb sharḥ al-mulakhkhaṣ al-mashhūr bi-al-Sharḥ al-Jighmīnī [microform] /

Microfilm.

The history of the Saracens : containing the lives of Abubeker, Omar, Othman, Ali, Hlafan, Moawiyah I. Yezid I. Moawiyah II. Abdolla, Merwan I. and Abdolmelick, the immediate successors of Mahomet. Giving an account of their most remarkable battles, sieges, &c. ... /

"Sentences of Ali, son-in-law of Mahomet, and his fourth successor, translated from an authentick Arabick manuscript ... by Simon Ockley." (19 p., v. 2) has separate t.-p.