Die Constäpler bleiben; kühl' Wetter bleibt! Nu noch de Cholera, denn is de Pulle voll! Neumann: Na die jestrige Sitzung von de Vertretersch in de Singe-Akademie is nich bitter jewesen ...

Welsch (Projektbearbeiter): Kritische Kommentierung der in der Preußischen Nationalversammlung am 9. August 1848 geführten Debatte über die Berliner Konstabler-Schutztruppe. In der Form einer Unterhaltung zwischen den Berliner Bürgern Neumann, Piesecke und Brennecke

Telegraphische Depesche aus Petersburg: Aufstand in Petersburg. Die Cholera wüthet. Rückzug der Grenzbesatzung: Mittelst einer besonders eingerichteten Telegraphen-Linie sind wir in den Stand gesetzt, das Publikum von den neuesten wichtigen Ereigenissen der russischen Hauptstadt zu unterrichten und veröffentlichen hiermit nachfolgende so eben eingetroffene Depesche unseres Petersburger Correspondenten: Petersburg ist im Aufstand: Seit drei Stunden wird in der ganzen Stadt Generalmarsch geschlagen ...

Welsch (Projektbearbeiter): Bericht über den Ausbruch von Straßenkämpfen in Sankt Petersburg aus konservativ/reaktionärer Sicht: "eine gewöhnliche Straßen-Emeute ... ohne politische Ansicht und Zweck ...". Zurückweisung von Gerüchten über einen bevorstehenden Angriff Rußlands auf Preußen

Responding to Price Signals in Communal Agriculture: Shaker Hog Production, 1788-1850

Isolated Shaker communal farms stressed self-sufficiency as an ideal but carefully chose which goods to buy and sell in external markets and which to produce and consume themselves. We use records of hog slaughter weights to investigate the extent to which the Shakers incorporated market-based price information in determining production levels of a consumption good which they did not sell in external markets: pork. Granger causality tests indicate that Shaker pork production decisions were influenced as hypothesized, strongly by corn prices and weakly by pork prices. We infer that attention to opportunity costs of goods that they produced and consumed themselves was a likely factor aiding the longevity of Shaker communal societies.

Ueber den Charakter, die Cur und die Verhütung der ostindischen Brechruhr (Cholera) : mit besonderer Berücksichtigung der Verhältnisse der Schweiz

von Joh. Hegetschweiler

Kurzgefaßte Darstellung der Asiatischen Cholera, ihrer Ausbildung und Fortpflanzung und der sichersten, bis jetzt bekannten Vorbauungs- und Ableitungsmittel dagegen, damit diese Krankheit in der Geburt erstickt werde; wie auch mit Angabe der sichersten Heilmethoden von den berühmtesten Aerzten, nebst einer Beschreibung des amerikanischen, arzneyhaltigen Dampfbades, nach J. I. Hawkins ...

von Julius Stephan Zerffi

Cholera und Juden

S. W.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 855 - Benachrichtigung über die Auswirkungen der Cholera in Berlin

u.a. Heinrich von Lowtzow alias Baron von Schöneberg;

Die Cholera in Chile

Von unserem Ehrenmitglied Dr. Karl Martin

Seawater carbonate chemistry in Hog reef and calcification rate in the Bermuda reef community, 2010

Despite the potential impact of ocean acidification on ecosystems such as coral reefs, surprisingly, there is very limited field data on the relationships between calcification and seawater carbonate chemistry. In this study, contemporaneous in situ datasets of seawater carbonate chemistry and calcification rates from the high-latitude coral reef of Bermuda over annual timescales provide a framework for investigating the present and future potential impact of rising carbon dioxide (CO2) levels and ocean acidification on coral reef ecosystems in their natural environment. A strong correlation was found between the in situ rates of calcification for the major framework building coral species Diploria labyrinthiformis and the seasonal variability of [CO32-] and aragonite saturation state omega aragonite, rather than other environmental factors such as light and temperature. These field observations provide sufficient data to hypothesize that there is a seasonal "Carbonate Chemistry Coral Reef Ecosystem Feedback" (CREF hypothesis) between the primary components of the reef ecosystem (i.e., scleractinian hard corals and macroalgae) and seawater carbonate chemistry. In early summer, strong net autotrophy from benthic components of the reef system enhance [CO32-] and omega aragonite conditions, and rates of coral calcification due to the photosynthetic uptake of CO2. In late summer, rates of coral calcification are suppressed by release of CO2 from reef metabolism during a period of strong net heterotrophy. It is likely that this seasonal CREF mechanism is present in other tropical reefs although attenuated compared to high-latitude reefs such as Bermuda. Due to lower annual mean surface seawater [CO32-] and omega aragonite in Bermuda compared to tropical regions, we anticipate that Bermuda corals will experience seasonal periods of zero net calcification within the next decade at [CO32-] and omega aragonite thresholds of ~184 micro moles kg-1 and 2.65. However, net autotrophy of the reef during winter and spring (as part of the CREF hypothesis) may delay the onset of zero NEC or decalcification going forward by enhancing [CO32-] and omega aragonite. The Bermuda coral reef is one of the first responders to the negative impacts of ocean acidification, and we estimate that calcification rates for D. labyrinthiformis have declined by >50% compared to pre-industrial times.

HOG-Like gradient-based descriptor for visual vehicle detection

One of the main challenges for intelligent vehicles is the capability of detecting other vehicles in their environment, which constitute the main source of accidents. Specifically, many methods have been proposed in the literature for video-based vehicle detection. Most of them perform supervised classification using some appearance-related feature, in particular, symmetry has been extensively utilized. However, an in-depth analysis of the classification power of this feature is missing. As a first contribution of this paper, a thorough study of the classification performance of symmetry is presented within a Bayesian decision framework. This study reveals that the performance of symmetry-based classification is very limited. Therefore, as a second contribution, a new gradient-based descriptor is proposed for vehicle detection. This descriptor exploits the known rectangular structure of vehicle rears within a Histogram of Gradients (HOG)-based framework. Experiments show that the proposed descriptor outperforms largely symmetry as a feature for vehicle verification, achieving classification rates over 90%.

Optimized HOG for on-road video based vehicle verification

Vision-based object detection from a moving platform becomes particularly challenging in the field of advanced driver assistance systems (ADAS). In this context, onboard vision-based vehicle verification strategies become critical, facing challenges derived from the variability of vehicles appearance, illumination, and vehicle speed. In this paper, an optimized HOG configuration for onboard vehicle verification is proposed which not only considers its spatial and orientation resolution, but descriptor processing strategies and classification. An in-depth analysis of the optimal settings for HOG for onboard vehicle verification is presented, in the context of SVM classification with different kernels. In contrast to many existing approaches, the evaluation is realized in a public and heterogeneous database of vehicle and non-vehicle images in different areas of the road, rendering excellent verification rates that outperform other similar approaches in the literature.

CTXφ immunity: Application in the development of cholera vaccines

CTXφ is a filamentous bacteriophage that encodes cholera toxin, the principal virulence factor of Vibrio cholerae. CTXφ is unusual among filamentous phages because it encodes a repressor and forms lysogens. CTXφ can infect the existing live-attenuated V. cholerae vaccine strains derived from either the El Tor or classical V. cholerae biotypes and result in vaccine reversion to toxinogenicity. Intraintestinal CTXφ transduction assays were used to demonstrate that El Tor biotype strains of V. cholerae are immune to infection with the El Tor-derived CTXφ, whereas classical strains are not. The El Tor CTXφ repressor, RstR, was sufficient to render classical strains immune to infection with the El Tor CTXφ. The DNA sequences of the classical and El Tor CTXφ repressors and their presumed cognate operators are highly diverged, whereas the sequences that surround this “immunity” region are nearly identical. Transcriptional fusion studies revealed that the El Tor RstR mediated repression of an El Tor rstA-lacZ fusion but did not repress a classical rstA-lacZ fusion. Likewise, the classical RstR only repressed a classical rstA-lacZ fusion. Thus, similar to the mechanistic basis for heteroimmunity among lambdoid phages, the specificity of CTXφ immunity is based on the divergence of the sequences of repressors and their operators. Expression of the El Tor rstR in either El Tor or classical live-attenuated V. cholerae vaccine strains effectively protected these vaccines from CTXφ infection. Introduction of rstR into V. cholerae vaccine strains should enhance their biosafety.

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit (S61F), which resulted in loss of ADP ribosyltransferase activity and toxicity. Mice were intranasally immunized with ovalbumin, tetanus toxoid, or influenza virus either alone or together with mutant CT S61F, native CT, or recombinant CT-B. Mice immunized with these proteins plus S61F showed high serum titers of protein-specific IgG and IgA antibodies that were comparable to those induced by native CT. Further, high protein-specific IgA antibody responses were observed in nasal and vaginal washes, saliva, and fecal extracts as well as increased numbers of IgG and IgA antibody forming cells in cervical lymph nodes and lung tissues of mice intranasally immunized with these proteins and S61F or native CT, but not with recombinant CT-B or protein alone. Both S61F and native CT enhanced the induction of ovalbumin-specific CD4+ T cells in lung and splenic tissues, and these T cells produced a Th2-type cytokine pattern of interleukin 4 (IL-4), IL-5, IL-6, and IL-10 as determined by analysis of secreted proteins and by quantitation of cytokine-specific mRNA. These results have shown that mutant CT S61F is an effective mucosal adjuvant when administrated intranasally and induces mucosal and systemic antibody responses which are mediated by CD4+ Th2-type cells.