Harengus hic piscis captus fuit 21. Novemb. 1587 inter Daniam et Norvegiam ... : Characteres erant nigri coloris & cutim penetrabant ad carnes

Bibliogr. Nachweis: Faust: Zoolog. Einblattdrucke ... I,102.2

Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

The role of channel inactivation in the molecular mechanism of calcium (Ca2+) channel block by phenylalkylamines (PAA) was analyzed by designing mutant Ca2+ channels that carry the high affinity determinants of the PAA receptor site [Hockerman, G. H., Johnson, B. D., Scheuer, T., and Catterall, W. A. (1995) J. Biol. Chem. 270, 22119–22122] but inactivate at different rates. Use-dependent block by PAAs was studied after expressing the mutant Ca2+ channels in Xenopus oocytes. Substitution of single putative pore-orientated amino acids in segment IIIS6 by alanine (F-1499-A, F-1500-A, F-1510-A, I-1514-A, and F-1515-A) gradually slowed channel inactivation and simultaneously reduced inhibition of barium currents (IBa) by (−)D600 upon depolarization by 100 ms steps at 0.1 Hz. This apparent reduction in drug sensitivity was only evident if test pulses were applied at a low frequency of 0.1 Hz and almost disappeared at the frequency of 1 Hz. (−)D600 slowed IBa recovery after maintained membrane depolarization (1–3 sec) to a comparable extent in all channel constructs. A drug-induced delay in the onset of IBa recovery from inactivation suggests that PAAs promote the transition to a deep inactivated channel conformation. These findings indicate that apparent PAA sensitivity of Ca2+ channels is not only defined by drug interaction with its receptor site but also crucially dependent on intrinsic gating properties of the channel molecule. A molecular model for PAA-Ca2+ channel interaction that accounts for the relationship between drug induced inactivation and channel block by PAA is proposed.

Drivers for and against municipal wastewater recycling: a review

The reclamation, treatment and reuse of municipal wastewater can provide important environmental benefits. In this paper, 25 studies on this topic were reviewed and it was found that there are many (\textgreater150) different drivers acting for and against wastewater recycling. To deal with the challenge of comparing studies which entailed different research designs, a framework was developed which allowed the literature to be organized into comparable study contexts. Studies were categorized according to the level of analysis (wastewater recycling scheme, city, water utility, state, country, global) and outcome investigated (development/investment in new schemes, program implementation, percentage of wastewater recycled, percentage of water demand covered by recycled water, multiple outcomes). Findings across comparable case studies were then grouped according to the type (for or against recycling) and category of driver (social, natural, technical, economic, policy or business). The utility of the framework is demonstrated by summarizing the findings from four Australian studies at the city level. The framework offers a unique approach for disentangling the broad range of potential drivers for and against water recycling and to focus on those that seem relevant in specific study contexts. It may offer a valuable starting point for building hypotheses in future work.

Why Do Some Water Utilities Recycle More than Others? A Qualitative Comparative Analysis in New South Wales, Australia

Although the recycling of municipal wastewater can play an important role in water supply security and ecosystem protection, the percentage of wastewater recycled is generally low and strikingly variable. Previous research has employed detailed case studies to examine the factors that contribute to recycling success but usually lacks a comparative perspective across cases. In this study, 25 water utilities in New South Wales, Australia, were compared using fuzzy-set Qualitative Comparative Analysis (fsQCA). This research method applies binary logic and set theory to identify the minimal combinations of conditions that are necessary and/or sufficient for an outcome to occur within the set of cases analyzed. The influence of six factors (rainfall, population density, coastal or inland location, proximity to users; cost recovery and revenue for water supply services) was examined for two outcomes, agricultural use and "heavy" (i.e., commercial/municipal/industrial) use. Each outcome was explained by two different pathways, illustrating that different combinations of conditions are associated with the same outcome. Generally, while economic factors are crucial for heavy use, factors relating to water stress and geographical proximity matter most for agricultural reuse. These results suggest that policies to promote wastewater reuse may be most effective if they target uses that are most feasible for utilities and correspond to the local context. This work also makes a methodological contribution through illustrating the potential utility of fsQCA for understanding the complex drivers of performance in water recycling.

G. H. G. Jahr's Manual of homoeopathic medicine.

Translation of his Klinische Anweisungen zu homöopathischer Behandlung der Krankheiten.

Sylloge selectiorum opusculorum : argumenti medico-practici.

Mode of access: Internet.

Zusammenstellungen über den zulässigen elliptischen und pleonastischen Gebrauch der englischen persönlichen Fürwörter.

At head of title: Oberrealschule auf der Uhlenhorst zu Hamburg.

Medicina homeopática doméstica ó Guía de las familias /

Mode of access: Internet.

Médecine homoeopathique domestique /

Mode of access: Internet.

Handbuch der physiologie,

Each part has also special t.-p.

Das Vogelschiessen zu Oschatz;

Mode of access: Internet.

Digest of data collected before the year 1908, relating to the sanitary condition of New York harbor.

section I. Investigations made by the New York Bay pollution commission in 1904 and 1906.--section II. Investigations made by the Metropolitan sewrage commission in 1907.--section III. Investigations made by the Department of water supply, gas and electricity of the city of New York in 1904 and 1905.--section IV. Investigastions made by C. F. Breitzke in 1906 of the sanitary condition of Gowanus canal.--section V. Investigation of the waters of the lower Hudson River by the Burr-Hering-Freeman commission in 1903.--section VI. Investigation of the condition of the Passaic River by Messrs. Hazen and Whipple in 1906.

Corso di operazioni di chirurgia veterinaria /

Mode of access: Internet.

Deutsche Predigten des XIII. Jahrhunderts,

Mode of access: Internet.