Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia

Genome-wide association studies followed by replication provide a powerful approach to map genetic risk factors for asthma. We sought to search for new variants associated with asthma and attempt to replicate the association with four loci reported previously (ORMDL3, PDE4D, DENND1B and IL1RL1). Genome-wide association analyses of individual single nucleotide polymorphisms (SNPs), rare copy number variants (CNVs) and overall CNV burden were carried out in 986 asthma cases and 1846 asthma-free controls from Australia. The most-associated locus in the SNP analysis was ORMDL3 (rs6503525, P = 4.8 x 10(-)(7)). Five other loci were associated with P < 10(-)(5), most notably the chemokine CXC motif ligand 14 (CXCL14) gene (rs31263, P = 7.8 x 10(-)(6)). We found no evidence for association with the specific risk variants reported recently for PDE4D, DENND1B and ILR1L1. However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). This association replicated convincingly in an independent cohort (P = 2.4 x 10(-)(4)). A 300-kb deletion on chromosome 17q21 was associated with asthma risk, but this did not reach experiment-wide significance. Asthma cases and controls had comparable CNV rates, length and number of genes affected by deletions or duplications. In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted.

Studio portrait of Sarah-Bertha Klarenmeyer nee Meyerhof called "Spatz" as a young woman. portraits women

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Studio portrait of Sarah-Bertha Klarenmeyer nee Meyerhof called Spatz Portrait Women

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Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Margarete Oppenheimer geb. Busch : 29. Mai 1883 - 8. August 1935.

Memorial book with the speeches by Leo Baeck and Hugo Jacobi.

Herman Bernstein 1897-1935

Correspondence, clippings, manuscripts, notes, reports, relating to Bernstein's journalistic, literary and diplomatic careers. Correspondence with well-known literary, political and communal, society personalities, 1908-1935. Includes Cyrus Adler, Viscount Allenby, Joseph Barondess, Bernard Baruch, Henri Bergson, Hayyim Nahman Bialik, Jacob Billikopf, Vladimir Bourtzeff, Louis Brandeis, Robert Cecil, Fyodor Chaliapin, Jacob de Haas, Albert Einstein, Henry Ford, Felix Frankfurter, Herbert Hoover, Vladimir Jabotinsky, Horace M. Kallen, Peretz Hirschbein, Peter Kropotkin, Herbert Lehman, Louis Lipsky, Judah L. Magnes, Louis Marshall, Henry Morgenthau, Max Nordau, Adolph Simon Ochs, David de Sola Pool, Bernard G. Richards, Theodore Roosevelt, Julius Rosenwald, Jacob Schiff, Harry Schneiderman, Maurice Schwartz, George Bernard Shaw, Sholem Aleichem, Nathan Straus, Henrietta Szold, Chaim Tchernowitz, Leo Tolstoy, Samuel Untermyer, Henry Van Dyke, Lillian Wald, Felix Warburg, Chaim Weizman n, Jefferson Williams, Stephen Wise, Israel Zangwill. Correspondence and other materials relating to Bernstein's post as U.S. ambassador to Albania. Materials pertaining to Bernstein's editorial work at *The Day*, *Jewish Tribune*, *New York Herald*, *Jewish Daily Bulletin*. Materials pertaining to Bernstein's involvement with the American Jewish Committee. Correspondence with organizations including American Jewish Congress, *American Hebrew*, HIAS, *Jewish Chronicle* (London), Jewish Community of New York, *Menorah Journal*, *New York American*, *New York Times*, ORT, U.S. Dept. of State, Yiddish Art Theater, Zionist Organization of America. Articles, clippings, correspondence and court materials relating to the Ford libel suit. Miscellaneous documents and reports relating to the Paris Peace Conference, the Jewish situation in Russia, 1917-1920, Russian revolutionary events of 1917. News dispatches from Russia, 1917-1920s. Translations by Bernstein of Russian wri Andre yev,

Philip Cowen papers undated, 1873-1935

Contains primarily correspondence and published material in English, German and Russian relating to anti-Semitism in Russia and Roumania, the Russian passport question, loans from Jewish bankers to the Russian government and immigration from Eastern Europe, especially Russia, to the United States. Includes also correspondence concerning Jewish welfare institutions and agricultural colonies in the United States and the National Farm School in Doylestown, Pa. Also contains correspondence relating to and drafts of articles for the American Hebrew, particularly the Emma Lazarus memorial number, and correspondence relating to the publication of the Jewish encyclopedia and to survey on anti-Semitism conducted in 1890, as well as information on the Jews in China and material relating to Count Arthur Cherep-Spiridovich.

Synagogue Council of America records 1935-1974

Contains the constitution, by-laws, correspondence, papers, and minutes of the Synagogue Council of America (1935-1958), an incomplete set of the minutes of the Plenum, (1949-1965), the minutes of the Executive Committee (1946-1969), Officers' (Summit) Meetings (1955-1967) and the minutes and reports of the Budget Committee (1946-1966), financial reports and statements for 1942-1965 and fundraising activities (1958-1968).

Aaron Lopez papers, undated, 1752-1794, 1846, 1852, 1953.

Contains approximately 6800 manuscripts arranged chronologically by year for years 1752-1794. Approximately 100 are letters received or written by Lopez, his partner and father-in-law, Jacob Rodriguez Rivera, members of his family and company, and commercial agents pertaining to business activities and sailing orders for the captains of various ships. Several also refer to personal matters and acquaintances, including a series of six letters from Silas Cooke of White Hall (Middletown), R.I., to Aaron Lopez, asking his aid in returning a run-away slave (1776). The great majority of the collection consists of account records, bills of sale, orders, shipping agreements, lists of sailors on the various ships, repair records and cargo invoices. Of particular interest are a receipt for payment of a half-year's subscription to the "tzedakah" of Congregation Nefutzei Israel, Newport (1755) and several documents that reveal Lopez as a supplier of kosher meat and other religious articles to people in various parts of the colonies, Surinam, and Jamaica. Also included in this group are copies of sailing lists, documents pertaining to Lopez's naturalization which shed light upon the status of a Jew applying for citizenship in Massachusetts and a check to Lopez from the United States government for a loan made during the Revolutionary War (1779).

Schmidl-Speyer Family Collection 1914-1935, 1988-1993

Autographs: Postcards and picture postcards (all photocopies) written by luminaries such as Richard Beer- Hofmann, Otto Brahm, Josef Floch to Paula Schmidl-Speyer, Anton Hanak, Theodor Herzl, Wilhelm Mueller-Hofmann, Arthur Schnitzler, Julius Wagner-Jauregg, Jakob Wassermann, and David Wolfson.

Max Strauss Collection 1911-1935

Documents, medals, and photos pertaining to Max Strauss' service in the German Army before and during World War I:

[Sehr verehrte Frau Alexander] 1935-1995

Two letters from Rabbi Leo Baeck in London to Mrs. Fred Alexander in Belmont, MA pertaining to common acquaintances in Theresienstadt; Dec. 10, 1945 and Jan 3, 1947.

Regina Teitelbaum Collection 1922-1935

Copies of photos and documents pertaining to Regina Teitelbaum's sports activities in Jewish sports events during the 1920s and 1930s, including clippings about these events (from Der Makkabi, 1935), and certificates for Teitelbaum's accomplishments.