Daguerreotype - Julia Canby Cleveland and her Doll

Daguerreotype of Julia Canby Cleveland and her doll. Both the doll and the girl have wide brimmed hats. The photograph is in an ornate wooden (compact-like) case with carved thistles. There is a latch on the case. The case is lined in velvet and the leather binding on the spine has come away.

Indenture between Samuel DeVeaux Woodruff and Her Majesty the Queen (copy)

Indenture between Samuel DeVeaux Woodruff and Her Majesty the Queen (copy) regarding Lots no. 20 and 21 in the 5th and 6th Concessions in the Town of Grantham (handwritten 3 pages), Aug. 16, 1880

Indenture of Conveyance between Her Majesty the Queen and Joseph A. Woodruff

Indenture of conveyance between Her Majesty the Queen and Joseph A. Woodruff of St. Catharines regarding 100 acres more or less in part of Lot no. 5 in the 2nd Concession in the 34 Township of Lobo in the County of Middlesex. This was registered in the County of Middlesex Register on Oct. 20, 1873. This is a duplicate of the original executed on Oct. 15, 1875.

Birthday Card to Margaret from her Father H.K. Woodruff

Birthday card and envelope to Margaret from her father H.K. Woodruff, April, 1916.

Funeral invitation to the funeral of Mrs. W.H. Dickson at the residence of her husband the Honourable Walter Hamilton Dickson

Funeral invitation to the funeral of Mrs. W.H. Dickson at the residence of her husband the Honourable Walter Hamilton Dickson, to St. Mark’s Church, Niagara. The invitation was sent to Mr. Waters. The item is torn and mouldy but the text is not affected, March 6, 1855.

Mexico and her military chieftains, from the revolution of Hidalgo to the present time : Comprising sketches of the lives of Hidalgo, Morelos, Iturbide, Santa Anna, Gomez, Farias, Bustamente, Paredes, Almonte, Arista, Alaman, Ampudia, Herrera, and De la Vega. by Fay. Robinson. Illustratd by twelve portraits and engravings.

UANL

Louisa of Prussia and her times : an historical novel

UANL

Louisa of Prussia and her times : an historical novel

UANL

Westward Hol : or the voyages and adventures of six amyas leight knight of burrough, in the country of de von in the reign of her most gorius majestry queen Elizabeth

UANL

« Il faut tuer Broadway » : création du Her Majesty's Theatre et des Soirées de famille du Monument National

En novembre 1898, Montréal vécut successivement trois événements majeurs qui allaient bouleverser sa vie théâtrale. Ce sont, le 7 novembre, l'inauguration du prestigieux Her Majesty's Theatre de la rue Guy — juste au nord de Sainte-Catherine —; puis, le 15, la première représentation publique des Soirées de famille au Monument national; enfin, le 21, l'ouverture du Théâtre des Variétés qui, malgré sa brève existence, revêt une importance historique considérable. [...]

An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: gefitinib (Iressatrade mark)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review)

Intrinsic resistance to the epidermal growth factor receptor (EGFR; HER1) tyrosine kinase inhibitor (TKI) gefitinib, and more generally to EGFR TKIs, is a common phenomenon in breast cancer. The availability of molecular criteria for predicting sensitivity to EGFR-TKIs is, therefore, the most relevant issue for their correct use and for planning future research. Though it appears that in non-small-cell lung cancer (NSCLC) response to gefitinib is directly related to the occurrence of specific mutations in the EGFR TK domain, breast cancer patients cannot be selected for treatment with gefitinib on the same basis as such EGFR mutations have been reported neither in primary breast carcinomas nor in several breast cancer cell lines. Alternatively, there is a general agreement on the hypothesis that the occurrence of molecular alterations that activate transduction pathways downstream of EGFR (i.e., MEK1/MEK2 - ERK1/2 MAPK and PI-3'K - AKT growth/survival signaling cascades) significantly affect the response to EGFR TKIs in breast carcinomas. However, there are no studies so far addressing a role of EGF-related ligands as intrinsic breast cancer cell modulators of EGFR TKI efficacy. We recently monitored gene expression profiles and sub-cellular localization of HER-1/-2/-3/-4 related ligands (i.e., EGF, amphiregulin, transforming growth factor-α, ß-cellulin, epiregulin and neuregulins) prior to and after gefitinib treatment in a panel of human breast cancer cell lines. First, gefitinibinduced changes in the endogenous levels of EGF-related ligands correlated with the natural degree of breast cancer cell sensitivity to gefitinib. While breast cancer cells intrinsically resistant to gefitinib (IC50 ≥15 μM) markedly up-regulated (up to 600 times) the expression of genes codifying for HERspecific ligands, a significant down-regulation (up to 106 times) of HER ligand gene transcription was found in breast cancer cells intrinsically sensitive to gefitinib (IC50 ≤1 μM). Second, loss of HER1 function differentially regulated the nuclear trafficking of HER-related ligands. While gefitinib treatment induced an active import and nuclear accumulation of the HER ligand NRG in intrinsically gefitinib-resistant breast cancer cells, an active export and nuclear loss of NRG was observed in intrinsically gefitinib-sensitive breast cancer cells. In summary, through in vitro and pharmacodynamic studies we have learned that, besides mutations in the HER1 gene, oncogenic changes downstream of HER1 are the key players regulating gefitinib efficacy in breast cancer cells. It now appears that pharmacological inhibition of HER1 function also leads to striking changes in both the gene expression and the nucleo-cytoplasmic trafficking of HER-specific ligands, and that this response correlates with the intrinsic degree of breast cancer sensitivity to the EGFR TKI gefitinib. The relevance of this previously unrecognized intracrine feedback to gefitinib warrants further studies as cancer cells could bypass the antiproliferative effects of HER1-targeted therapeutics without a need for the overexpression and/or activation of other HER family members and/or the activation of HER-driven downstream signaling cascades

Educaci?? : her??ncies del segle XX. 'Educaci??n : herencias del siglo XX'

El art??culo es transcripci??n de una conferencia pronunciada en la sede del Colegio de Doctores y Licenciados de las Balears el d??a 25 de octubre de 1999, con motivo de la celebraci??n del primer centenario del Colegio

La educaci??n her??ica y agonal en el mundo Hom??rico y su repercusi??n en las manifestaciones art??sticas

Resumen basado en el de la publicaci??n. Monogr??fico con el t??tulo: Historia de la Educaci??n F??sica

A family in the First World War : Katy finds out about her great grandmother.

Primer volumen de una serie de seis libros que narra la historia de la familia de Katy desde 1910 a 1960. Éste se centra en la Primera Guerra Mundial y narra la vida cotidiana de sus bisabuelos hasta el estallido de la Gran Guerra. El texto se acompaña de una pequeña tabla con el precio de algunos alimentos y productos y el sueldo en algunos oficios.

A family in the 1920s : Katy finds out about her great grandparents.

Segundo volumen de una serie de seis libros que narra la historia de la familia de Katy desde 1910 hasta 1960. Éste se centra en la década de los años veinte y narra la dura vida cotidiana en el hogar de su bisabuela, cómo eran los transportes y las diversiones. El texto se acompaña de una pequeña tabla con el precio de algunos alimentos y productos y el sueldo de algunos oficios.