Biblia Sacra vulgate editores Sixti V. et Clementis VII Pont. Max. auctroritate recognita, cum notis choronologieis et historicis exemplaris vitreani, et indice geographico J. B. Du-hamel

UANL

Um estudo sobre a concepção de paradoxo segundo o pensamento de Augustus de Morgan

This work aims to analyze the concept of "paradox" posed in the work of The Budget Paradox (1872) of mathematical and logical English Augustus De Morgan (1806-1871). Here it is important to note that a large part of this book consists of re-prints of a series of writings by the author in journal Athenaeum, where its performance as auditor of literature. The tests refer to some scientific work produced between the years 1489 and 1866 and the rules of selection for the composition of the work is, basically, the methodological aspects used in the completion or disclosed by such scholars. The concept of paradox is presented in two distinct moments. At first, we found a study of definitions for the term in a philosophical approach, characterizing it as something that requires further investigation; which was complemented with the classic examples of a scientific context. In the second, we present a concept advocated by De Morgan and, under this perspective, that he conceptualized the "paradox" is directly related to the non-usual methods employed in the formulation of new scientific theories. In this study some of these scientific concepts are detailed, where, through the redemption history, engaging in issues of our study Mathematics, Physics, of Logic, among others. Possession of the preliminary analysis and comparison with the design of De Morgan, it became possible to diagnose some limitations in the conceptualization suggested by the author. Further, evidenced, in front of the cases, the nonlinearity of the process of production of knowledge and hence the progress of science

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Ethnopharmacological relevance Propolis is a bee product with numerous biological and pharmacological properties, such as immunomodulatory and anti-inflammatory activities. It has been used in folk medicine as a healthy drink and in food to improve health and prevent inflammatory diseases. However, little is known about its mechanism of action. Thus, the goal of this study was to verify the antioxidant activity and to explore the anti-inflammatory properties of propolis by addressing its intracellular mechanism of action. Caffeic acid was investigated as a possible compound responsible for propolis action. Materials and methods The antioxidant properties of propolis and caffeic acid were evaluated by using the 2,2-Diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging method. To analyze the anti-inflammatory activity, Raw 264.7 macrophages were treated with different concentrations of propolis or caffeic acid, and nitric oxide (NO) production, a strong pro-inflammatory mediator, was evaluated by the Griess reaction. The concentrations of propolis and caffeic acid that inhibited NO production were evaluated on intracellular signaling pathways triggered during inflammation, namely p38 mitogen-activated protein kinase (MAPK), c-jun NH2-terminal kinase (JNK1/2), the transcription nuclear factor (NF)-κB and extracellular signal-regulated kinase (ERK1/2), through Western blot using specific antibodies. A possible effect of propolis on the cytotoxicity of hepatocytes was also evaluated, since this product can be used in human diets. Results Caffeic acid showed a higher antioxidant activity than propolis extract. Propolis and caffeic acid inhibited NO production in macrophages, at concentrations without cytotoxicity. Furthermore, both propolis and caffeic acid suppressed LPS-induced signaling pathways, namely p38 MAPK, JNK1/2 and NF-κB. ERK1/2 was not affected by propolis extract and caffeic acid. In addition, propolis and caffeic acid did not induce hepatotoxicity at concentrations with strong anti-inflammatory potential. Conclusions Propolis exerted an antioxidant and anti-inflammatory action and caffeic acid may be involved in its inhibitory effects on NO production and intracellular signaling cascades, suggesting its use as a natural source of safe anti-inflammatory drugs. © 2013 Elsevier B.V.

Adaptive morphology of the heart of Southern-Fur-Seal (Arctocephalus australis - Zimmermamm, 1783)

Funda��ão de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Observation of the rare B-s(0)->mu(+)mu(-) decay from the combined analysis of CMS and LHCb data

Coordena��ão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model

Coordena��ão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Die Geschichte der "Königswarter-Stiftung" in Meran 1872 - 1907 : [... Rafael Hausmann zur Feier seines 70. Geburtstages ...]

von A.Tänzer

Geschiedkundig overzicht over een kwarteeuw, uitgebracht in de algemeene vergadering tot herdenking van het 25-jarig bestaan der stichting, op zondag 21 Augustus 1898

Israe͏̈litisch Ziekenhuis te 's-Gravenhage, opgericht in 1873 / [B.Blok]

Die Vertreibung der Juden aus der Bukowina 1774 - 1783

Aus: Jeschurun 15,1/2, 3/4

Ḥamiššā ḥūmšê Tôrā bi-lšôn a��kenaz : ṣe'ênā û-re'ênā benôt Ṣiyyôn b��-ʿa���ārā

še ʿiṭṭēr lākem ... Ya��aqôv Ben- ... Yiṣḥāq ... mim-mišpa���at rabb��nû ... be-q"q Yānôw

Ueber hebräische Poesie : Vortrag gehalten im Rathhaussaale zu Zürich am 22. Februar 1872

von Heinrich Steiner