Métabolisme du magnésium pour le clinicien : une mise au point actuelle et simple [Magnesium metabolism for clinical practioner : an up to date review]

La mesure de la fraction libre du magnésium circulant est désormais possible grâce aux électrodes sélectives. Lors d'une déplétion magnésique l'enquête étiologique est orientée par la comparaison de la magnésiurie et de la magnésémie. Les syndromes de Bortter, ou alcaloses hypokaliémiques d'origine rénale, sont des tubulopathies primitives définies par des signes simples: tension artérielle normale; alcalose hypokaliémiques; excrétion rénale conservée des chlorures et recherche de diurétiques négative dans les urines. Grâce à la mesure de la magnésémie et de la calciurie on distingue au moins deux alcaloses hypokaliémiques d'origine rénale, la maladie de Gitelman et le syndrome de Bartter au sens strict.

HSE Midland Regional Hospital, Portlaoise Perinatal Deaths (2006-date)

The Minister for Health requested the Chief Medical Officer to prepare a Report for him on issues that arose following a Primetime Investigates programme relating to Portlaoise Hospital Maternity Services (PHMS) on 30th January 2014. This Report provides a preliminary assessment of PHMS focusing on perinatal deaths (2006-date) and related matters. Through a series of recommendations it sets out the need for further examination or actions where the findings of this preliminary assessment suggest such a need. It also makes clear who should be responsible for these further examinations or actions.   Download the Report

Mental health and growing up factsheet. Cannabis and mental health: information for young people.

About this leaflet This is one in a series of leaflets for parents, teachers and young people entitled Mental Health and Growing Up. These leaflets aim to provide practical, up-to-date information about mental health problems (emotional, behavioural and psychiatric disorders) that can affect children and young people. This leaflet gives you some basic facts about cannabis and also how it might affect your mental health. Introduction Lots of young people want to know about drugs. Often, people around you are taking them, and you may wonder how it will make you feel. You may even feel under pressure to use drugs in order to fit in, or be â?~coolâ?T. You may have heard that cannabis is no worse than cigarettes, or that it is harmless. What is cannabis? The cannabis plant is a member of the nettle family that has grown wild throughout the world for centuries. People have used it for lots of reasons, other than the popular relaxing effect. It comes in two main forms: ï,§ resin, which is a brown black lump also known as bhang, ganja or hashish ï,§ herbal cannabis, which is made up of the dried leaves and flowering tops, and is known as grass, marijuana, spliff, weed, etc. Skunk cannabis is made from a cannabis plant that has more active chemicals in it (THC), and the effect on your brain is stronger. Because â?~streetâ?T cannabis varies so much in strength, you will not be able to tell exactly how it will make you feel at any particular time. What does it do to you? When you smoke cannabis, the active compounds reach your brain quickly through your bloodstream. It then binds/sticks to a special receptor in your brain. This causes your nerve cells to release different chemicals, and causes the effects that you feel. These effects can be enjoyable or unpleasant. Often the bad effects take longer to appear than the pleasant ones. ï,§ Good/pleasant effects: You may feel relaxed and talkative, and colours or music may seem more intense. ï,§ Unpleasant effects: Feeling sick/panicky, feeling paranoid or hearing voices, feeling depressed and unmotivated. Unfortunately, some people can find cannabis addictive and so have trouble stopping use even when they are not enjoying it. The effects on your mental health Using cannabis triggers mental health problems in people who seemed to be well before, or it can worsen any mental health problems you already have. Research has shown that people who are already at risk of developing mental health problems are more likely to start showing symptoms of mental illness if they use cannabis regularly. For example if someone in your family has depression or schizophrenia, you are at higher risk of getting these illness when you use cannabis. The younger you are when you start using it, the more you may be at risk. This is because your brain is still developing and can be more easily damaged by the active chemicals in cannabis. If you stop using cannabis once you have started to show symptoms of mental illness, such as depression, paranoia or hearing voices, these symptoms may go away. However, not everyone will get better just by stopping smoking. If you go on using cannabis, the symptoms can get worse. It can also make any treatment that your doctor might prescribe for you, work less well. Your illness may come back more quickly, and more often if you continue to use cannabis once you get well again. Some people with mental health problems find that using cannabis makes them feel a bit better for a while. Unfortunately this does not last, and it does nothing to treat the illness. In fact, it may delay you from getting help you need and the illness may get worse in the longer term. [For the full factsheet, click on the link above]This resource was contributed by The National Documentation Centre on Drug Use.

Influència del clima en la fenologia de la floració de Globularia alypum: anàlisi a partir de mostres d'herbari

Globularia alypum és un arbust termòfil típic de la regió oest del Mediterrani. Aquest nanofaneròfit té un patró de floració molt ampli. Les poblacions primerenques floreixen des del Juliol fins al Desembre i les poblacions tardanes des del Gener fins a l’Abril. L’objectiu del projecte és esbrinar quins factors climàtics determinen la fenologia de la floració de l’espècie a partir de mostres d’herbari i conèixer l’abast geogràfic d’ambdós patrons de floració a la península Ibèrica i França. També l’estudi d’altres característiques fenològiques en relació amb el clima: els braquiblasts i les espigues de capítols. Els plecs d’herbari han estat georeferenciats per ser utilitzats en un entorn SIG junt amb les dades del clima i s’ha realitzat una anàlisi estadística. El resultats mostren que les poblacions primerenques creixen majoritàriament en zones costaneres mentre que les tardanes ho fan en zones continentals. Les poblacions primerenques creixen en àrees on les temperatures (mitjana, mínima, màxima i mínima del mes més fred) són més altes que les tardanes per l’efecte temperador del mar. Al analitzar totes les poblacions, el nombre de mesos des de la transició floral es correlaciona negativament amb la temperatura mínima mensual i la temperatura mitjana mensual en tots els mesos, mentre que amb la temperatura màxima mensual entre Octubre i Abril. Al estudiar sols les poblacions tardanes les correlacions són similars, però no en les primerenques on no se’n troba cap. Les correlacions entre el nombre de mesos des de la transició floral i les variables climàtiques anuals són iguals, a més de trobar-se una correlació negativa amb la temperatura mínima del mes més fred i l’índex tèrmic, i positiva amb l’índex de continentalitat. No s’ha trobat cap diferència en presència de braquiblasts segons la població, però sí en les espigues de capítols, essent més freqüents en les poblacions primerenques. Es suggereix que la temperatura és un factor més determinant per a les poblacions tardanes, mentre que es desconeix si és la precipitació en les primerenques. Tampoc es té coneixement sobre si les diferències entre els dos patrons són genètiques o fenotípiques i quin mecanisme possibilita el desenvolupament de braquiblasts i espigues de capítols.

Rate of gene sequence evolution and species diversification in flowering plants: a re-evaluation

Barraclough and co-workers (in a paper published in 1996) observed that there was a significant positive correlation between the rate of evolution of the rbcL chloroplast gene within families of flowering plants and the number of species in those families. We tested three additional data sets of our own (based on both plastid and nuclear genes) and used methods designed specifically for the comparison of sister families (based on random speciation and extinction). We show that, over all sister groups, the correlation between the rate of gene evolution and an increased diversity is not always present. Despite tending towards a positive association, the observation of individual probabilities presents a U-shaped distribution of association (i.e. it can be either significantly positive or negative). We discuss the influence of both phylogenetic sampling and applied taxonomies on the results.

Tres notes sobre l’Ars predicandi populo de Francesc Eiximenis (autoria, datació i contingut) = Three notes on the Ars Predicandi populo of Francesc Eiximenis (authorship, date and content)

In spite of the fact that the Ars predicandi populo is attributed to Eiximenis in only one of the three extant manuscripts, there is no doubt that it is one of his works.First of all, the internal references to this treatise in the pages of Terç and Dotzè del Crestià are an irrefutable testimony and, secondly, the presence of an autographvolume of sermons which begins with the Ars in the inventory of the Eiximenis library made shortly after his death. The writing of the Ars and the collection of sermons which introduces it must be dated prior to the beginning of the Crestià encyclopedia (1379) because of the complexity that entailed the writing of a collection of three perhaps four volumes of sermons. Due to a series of formal and codicological reasons it must be concluded that the chapter entitled De consiliis circa predicacionem cannot be attributed to Eiximenis and thus be excluded from the Ars