Effect of topical application of 5-FU on the corneoscleral limbus of rabbits

• Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization.

Tempo de jejuar e resistir: a presença do kung-fu no treinamento do ator : a experiência extracotidiana no teatro vocacional em proposição épica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito do laser terapêutico na mucosite induzida por 5-fluoruracila (5-FU) em hamsters

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Influência do treinamento do kung fu estilo Garra de Águia na capacidade cardiorrespiratória em adultos

Introdução: O Kung Fu é um sistema de luta desenvolvida na China por meio de observações dos movimentos dos animais, e principalmente da necessidade dos monges praticarem alguma atividade física. Poucos estudos têm verificado os benefícios do Kung Fu não só como uma arte marcial, mas também como uma opção de exercício físico para quem busca uma boa qualidade de vida e melhora na aptidão cardiovascular através da filosofia de buscar a cada dia o extremo, a perfeição e o equilíbrio. Objetivo: Verificar a influência do treinamento de 12 semanas de Kung Fu estilo garra de águia em praticantes iniciantes adultos na capacidade cardiorrespiratória. Metodologia: Participaram do presente estudo 21 estudantes com idade entre 18 e 25 anos, divididos em grupo controle (n=10) e grupo treinamento (n=11). O grupo treinamento foi submetido a 12 semanas de treino e o grupo controle constituído por participantes que não praticavam atividade física de forma regular e que mantiveram sua rotina de vida normal. O protocolo de esteira rolante do teste de VO2 máximo foi utilizado antes e após 12 semanas. As aulas ocorreram duas vezes por semana na UNESP e tiveram duração de uma hora e meia cada aula, sendo dividida em quatro partes: aquecimento, condicionamento físico, alongamento e técnica. Para análise estatística, os dados foram separados de acordo com grupo e gênero. Devido à natureza paramétrica dos dados, foi realizada análise anova fatorial e adotado um p≤0,05. Todas as análises foram realizadas no programa estatístico SPSS. Resultados: O grupo controle apresentou os seguintes valores de Vo2pico: Masculino (n=6) - pré 38,8±8,0mL.kg−1.min−1 e pós 38,5±7,6mL.kg−1.min−1; Feminino (n=4) - pré 37,5±4,2mL.kg−1.min−1 e pós 38,0±4,1mL.kg−1.min−1. O grupo treinamento apresentou: Masculino (n=7) - pré 55,4±3,0mL.kg−1.min−1 e pós 55,3±3,7mL.kg−1.min−1; Feminino (n=4) - pré...

L'anno che non fu? L'anno dell'Europa e la crisi nelle relazioni transatlantiche, 1973/74

The 1970s are in the limelight of a growing historiographic attention, partly due to the recent opening of new archival resources. 1973, in particular, has a special interest in the historian’s eyes, as many are the events that happened that year: to name but a few, the Chilean coup, the October War, the ensuing oil crisis, the Vietnamese peace treaty. So it is may be not entirely surprising that not much attention has been paid to the Year of Europe, a nebulous American initiative destined to sum up to nothing practical - as Kissinger himself put it, it was destined to be the Year that never Was.1 It is my opinion, however, that its failure should not conceal its historical interest. Even though transatlantic relations have sometimes been seen as an uninterrupted history of crisis,2 in 1973 they reached what could then be considered as their unprecedented nadir. I believe that a thorough analysis of the events that during that year found the US increasingly at odds with the countries of Western Europe is worth carrying out not only to cast a new light on the dynamics of transatlantic relations but also to deepen our comprehension of the internal dynamics of the actors involved, mainly the Nixon administration and a unifying Europe. The Nixon administration had not carefully planned what the initiative actually should have amounted to, and its official announcement appears to have been one of Kissinger’s coups de theatre. Yet the Year of Europe responded to the vital priority of revitalising the relations with Western Europe, crucial ally, for too long neglected. But 1973 did not end with the solemn renewal of the Atlantic Declaration that Kissinger had sought. On the contrary, it saw, for the first time, the countries of the newly enlarged EC engaged in a real, if short-lived, solidarity on foreign policy, which highlighted the Nixon administration’s contradictions regarding European integration. Those, in addition to the numerous tensions that already strained transatlantic relations, gave birth to a downward spiral of incomprehensions and misperceptions, which the unexpected deflagration of the October war seriously worsened. However, even though the tensions did not disappear, the European front soon started to disintegrate, mainly under the strains imposed by the oil crisis. Significant changes in the leadership of the main European countries helped to get the tones back to normal. During the course of 1974-5, the substantial failure of the Euro-Arab dialogue, the Gymlich compromise, frequent and serene bilateral meetings bear witness that the worst was over.

Traduzione di un racconto di Fuʼad al-Takarli

Il presente elaborato consiste in una proposta di traduzione di un racconto breve dello scrittore iracheno Fuʼad al-Takarli dal titolo Ḫazīn al-Lāmarʼiyāt. Nel capitolo primo verranno illustrati vita e opere principali dell'autore. Nel capitolo secondo verrà invece brevemente ripercorsa la storia del racconto breve arabo dalle sue origini. Il capitolo terzo conterrà il testo originale del racconto e la relativa traduzione a fronte, con il rispettivo commento a piè di pagina. L'elaborato si chiude con la bibliografia.

Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1

AIM: The mTOR-inhibitor rapamycin has shown antitumor activity in various tumors. Bedside observations have suggested that rapamycin may be effective as a treatment for colorectal carcinomatosis. METHODS: We established an orthotopic syngenic model by transplanting CT26 peritoneal tumors in Balb/C mice and an orthotopic xenograft model by transplanting SW620 peritoneal tumors in nu/nu mice. Expression levels of tissue inhibitor of matrix-metalloproteinases 1 (TIMP-1) in the tumor and serum was determined by enzyme-linked immunosorbent assay. RESULTS: Rapamycin significantly suppressed growth of syngenic and xenografted peritoneal tumors. The effect was similar with intraperitoneal or oral rapamycin administration. Tumor suppression was further enhanced when rapamycin was combined with 5-fluorouracil and/or oxaliplatin. The combination treatment showed no acute toxicity. TIMP-1 serum levels correlated well (CC = 0.75; P < 0.01) with rapamycin treatment. CONCLUSIONS: Rapamycin suppressed advanced stage colorectal cancer, even with oral administration. Combining rapamycin with current chemotherapy regimens significantly increased antitumor efficacy without apparent toxicity. The treatment efficacy correlated with serum TIMP-1 levels, suggesting its potential as a surrogate marker in future clinical trials.