Dusty punch cards and an eternal enigma: high-density lipoproteins and atherosclerosis

Epidemiological, clinical, and experimental evidence has accumulated during the last decades suggesting that high-density lipoproteins (HDLs) may protect from atherosclerosis and its clinical consequences. However, more than 55 years after the first description of the link between HDL and heart attacks, many facets of the biochemistry, function, and clinical significance of HDL remain enigmatic. This applies particularly to the completely unexpected results that became available from some recent clinical trials of nicotinic acid and of inhibitors of cholesteryl ester transfer protein (CETP). The concept that raising HDL cholesterol by pharmacological means would decrease the risk of vascular disease has therefore been challenged.

Obstetrical Forceps: History, Mystery, and Morality

The history of obstetrical forceps has almost always been one cloaked in controversy after a long history of being shrouded in mystery. Forceps have a long history and have evolved from facilitating the delivery of dead fetuses to aiding in the delivery and survival of live babies. In the middle of all of this arises the story of the Chamberlain family whose contribution was enormous but whose behaviors pushed at the envelope of (at least) our present-day concepts of medical ethics. This lecture traces an interesting story that spans a millennium.

Cortical Abnormalities in Adults and Adolescents with Major Depression based on Brain Scans from 20 Cohorts Worldwide in the ENIGMA Major Depressive Disorder Working Group

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen’s d effect sizes: −0.10 to −0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: −0.26 to −0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.

Bible mystery and Bible meaning.

Lettered on cover: Enlarged ed.

The phantom army: being the story of a man and a mystery /

Mode of access: Internet.

James VI and the Gowrie mystery,

Mode of access: Internet.

An introduction to theosophy, or the science of the "Mystery of Christ", that is, of deity, nature, and creature : embracing the philosophy of all the working powers of life, magical and spiritual ... Vol. I. complete in itself

Los vols. proyectados no se publicaron.

The village mystery, and Through war to peace,

Mode of access: Internet.

The secrets of Mahatma land explained, teaching and explaining the performances of the most celebrated oriental mystery makers and magicians in all parts of the world ...

Mode of access: Internet.

The prologue in the Old French and Provençal mystery,

Bibliography: p. 198-199.

Verbum crucis : being ten sermons on the mystery and the words of the Cross : to which are added some other sermons preached on public occasions /

Includes bibliographical references (p. [193]).

Mystery of godliness considered in LXI sermons wherein the deity of Christ is prov'd upon no other evidence than the word of God and with no other view than the salvation of men /

Mode of access: Internet.

Divine conduct : or, The mystery of providence, wherein the being and efficacy of providence are asserted and vindicated ... and the proper course of improving all providences pointed out /

Mode of access: Internet.