Inez Fabbri-Mulder als Gräfin Almaviva, Rollenbild, in: Wolfgang Amadeus Mozart: Le Nozze di Figaro

Signatur des Originals: S 36/F11522

Der Barbier von Sevilla : Figaro: Ich bin das Fac-totum Der schönen Welt,-

Signatur des Originals: S 36/G00170

Maria Dickons als Rosina, Rollenbild, in: Gioacchino Rossini: Il Barbiere di Siviglia, 1. Akt, 2. Szene : Ah! Figaro

Signatur des Originals: S 36/G00719

Figaro's Hochzeit. III. Act. Graf: "Willst in den Garten kommen?" Susanne: "Ich komme ganz gewiss."

Signatur des Originals: S 36/G02659

Enrico delle Sedie als Figaro, Rollenbild, in: Wolfgang Amadeus Mozart: Il barbiere di Siviglia, Berlin: Victoria-Theater

Signatur des Originals: S 36/G12946

Schieroni als Susanna, Rollenbild, in: Wolfgang Amadeus Mozart: Le Nozze di Figaro

Signatur des Originals: S 36/G04605

Los dos Fígaros ó El asunto de una comedia [Texto impreso] : melodrama en dos actos = I due Figaro, ossia Il soggetto di una comedia : melodrama in due atti

Para representar en el Teatro de Valencia en 1841

Dénonciation au public du voyage d'un soi-disant Figaro en Espagne,

Mode of access: Internet.

Le mariage de Figaro.

Sequel to the Barbier de Séville; first published 1785 under title: La folle journée.

Le mariage de Figaro; comédie en cinq actes, en prose

First published under title La folle journée, ou Le mariage de Figaro, 1785.

Mozart's opera, Marriage of Figaro,

Libretto by Lorenzo da Ponte, founded on La folle journée; ou, Le mariage de Figaro, a comedy by Beaumarchais.

Interação entre consumo alimentar e polimorfismos da GSTM1 e GSTT1 no risco para o câncer de cabeça e pescoço: estudo caso-controle em São Paulo, Brasil

O objetivo foi investigar a interação entre fatores dietéticos e polimorfismos de enzimas de metabolização de xenobióticos (GSTM1 e GSTT1) associadas ao câncer de cabeça e pescoço em um estudo caso controle de base hospitalar, no Município de São Paulo, Brasil. Participaram 103 casos incidentes, histologicamente confirmados, e 101 controles. O consumo alimentar foi obtido por um questionário de frequência alimentar validado. Os polimorfismos GSTM1 e GSTT1 foram avaliados pelo método PCR. Observou-se aumento de risco no mais alto tercil de consumo de carne bovina na presença do alelo nulo da GSTM1 (OR = 10,79; IC95%: 2,17-53,64) e GSTT1 (OR = 3,41; IC95%: 0,43-27,21). Considerando-se a razão entre alimentos de origem animal e vegetal, verificou-se para o tercil intermediário a OR = 2,02 (IC95%: 0,24-16,0) e no tercil superior OR = 3,23 (IC95%: 0,40-25,92). Os resultados apontam para uma possível interação entre o consumo de carne e variantes polimórficas dos genes GSTM1 e GSTT1 na modulação do risco para o câncer de cabeça e pescoço, influenciados pelo consumo de alimentos de origem vegetal.

Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy

In breast cancer patients, primary chemotherapy is associated with the same survival benefits as adjuvant chemotherapy. Residual tumors represent a clinical challenge, Lis they may be resistant to additional cycles of the same drugs. Our aim was to identify differential transcripts expressed in residual tumors, after neoadjuvant chemotherapy, that might be related with tumor resistance. Hence, 16 patients with paired tumor samples, collected before and after treatment (4 cycles doxorubicin/cyclophosphamide, AC) had their gene expression evaluated on cDNA microarray slides containing 4,608 genes. Three hundred and eighty-nine genes were differentially expressed (paired Student`s t-test, pFDR<0.01) between pre- and post-chemotherapy samples and among the regulated functions were the JNK cascade and cell death. Unsupervised hierarchical clustering identified one branch comprising exclusively, eight pre-chemotherapy samples and another branch, including the former correspondent eight post-chemotherapy samples and other 16 paired pre/post-chemotherapy samples. No differences in clinical and tumor parameters could explain this clustering. Another group of I I patients with paired samples had expression of selected genes determined by real-time RT-PCR and CTGF and DUSP1 were confirmed more expressed in post- as compared to pre-chemotherapy samples. After neoadjuvant chemotherapy some residual samples may retain their molecular signature while others present significant changes in their gene expression, probably induced by the treatment. CTGF and DUSP1 overexpression in residual samples may be a reflection of resistance to further administration of AC regimen.