890 resultados para Early christian literature Bible gospel Theology Critical edition


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by H. Michelson

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The effects of testosterone on early atherogenesis and the role of aromatase, an enzyme that converts testosterone to estrogens, were assessed in low density lipoprotein receptor-deficient male mice fed a Western diet. Castration of male mice increased the extent of fatty streak lesion formation in the aortic origin compared with testes-intact animals. Administration of anastrazole, a selective aromatase inhibitor, to testes-intact males increased lesion formation to the same extent as that observed with orchidectomized animals. Testosterone supplementation of orchidectomized animals reduced lesion formation when compared with orchidectomized animals receiving the placebo. This attenuating effect of testosterone was not observed when the animals were treated simultaneously with the aromatase inhibitor. The beneficial effects of testosterone on early atherogenesis were not explained by changes in lipid levels. Estradiol administration to orchidectomized males attenuated lesion formation to the same extent as testosterone administration. Aromatase was expressed in the aorta of these animals as assessed by reverse transcription–PCR and immunohistochemistry. These results indicate that testosterone attenuates early atherogenesis most likely by being converted to estrogens by the enzyme aromatase expressed in the vessel wall.

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"A continuation of the labors of Mr. Alexander Kenmure ... and of the still earlier work of Dr. Alexander Wylie."--Pref.

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Bibliography: p. 143-147.

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First published under title: Ante-Nicene Christian library.

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Mode of access: Internet.

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Mode of access: Internet.

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Title from spine; each vol. has special t.p. only.

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At head of title: Illustrated handbooks of art history.