Streaming Support for Data Intensive Cloud-Based Sequence Analysis

Cloud computing provides a promising solution to the genomics data deluge problem resulting from the advent of next-generation sequencing (NGS) technology. Based on the concepts of “resources-on-demand” and “pay-as-you-go”, scientists with no or limited infrastructure can have access to scalable and cost-effective computational resources. However, the large size of NGS data causes a significant data transfer latency from the client’s site to the cloud, which presents a bottleneck for using cloud computing services. In this paper, we provide a streaming-based scheme to overcome this problem, where the NGS data is processed while being transferred to the cloud. Our scheme targets the wide class of NGS data analysis tasks, where the NGS sequences can be processed independently from one another. We also provide the elastream package that supports the use of this scheme with individual analysis programs or with workflow systems. Experiments presented in this paper show that our solution mitigates the effect of data transfer latency and saves both time and cost of computation.

Latest Cretaceous to Late Paleocene radiolarian biostratigraphy from the New Zealand region

The scarcity of records of Early Paleocene radiolarians has meant that while radiolarian biostratigraphy is firmly established as an important tool for correlation, there has been a long-standing gap between established zonations for the Cretaceous and from latest Paleocene to Recent. It has also led to considerable speculation over the level of faunal change across the Cretaceous/Tertiary (K/T) boundary. Consequently, the discovery of rich and diverse radiolarian assemblages in well-delineated K/T boundary sections within siliceous limestones of the Amuri Limestone Group in eastern Marlborough, New Zealand, is of great significance for biostratigraphy and K/T boundary research. This initial report is restricted to introducing a new latest Cretaceous to mid Late Paleocene zonation based on the radiolarian succession at four of these sections and a re-examination of faunas from coeval sediments at DSDP Site 208 (Lord Howe Rise). Three new Paleocene species are described: Amphisphaera aotea, Amphisphaera kina and Stichomitra wero. Six new interval zones are defined by the first appearances of the nominate species. In ascending order these are: Lithomelissa? hoplites Foreman (Zone RK9, Cretaceous), Amphisphaera aotea n. sp. (Zone RP1, Paleocene), Amphisphaera kina n. sp. (RP2), Stichomitra granulata Petrushevskaya (RP3), Buryellaforemanae petrushevskaya (RP4) and Buryella tetradica (RP5). Good age control from foraminifera and calcareous nannofossils permits close correlation with established microfossil zonations. Where age control is less reliable, radiolarian events are used to substantially improve correlation between the sections. No evidence is found for mass extinction of radiolarians at the end of the Cretaceous. However, the K/T boundary does mark a change from nassellarian to spumellarian dominance, due to a sudden influx of actinommids, which effectively reduces the relative abundance of many Cretaceous survivors. An accompanying influx of diatoms in the basal Paleocene of Marlborough, together with evidence for an increase of total radiolarian abundance, suggests siliceous plankton productivity increased across the K/T boundary. Possible causes for this apparently localised phenomenon are briefly discussed.

Der neue Fund zur Sintflutgeschichte aus der Tempelbibliothek von Nippur.

Tr. by Dr. Rudolf Zehnpfund.

The garden of Eden and the flood.

Attempts to locate the garden of Eden in North America, on the strength of the fossil discoveries in the "Ashley beds" of South Carolina.

One hundred lectures on the ancient and modern dramatic poets,... down to the 19th century, commencing with Thespic, 6th century B.C.

Each v. contains nine lectures.

Le déluge mosaïque, l'historie et la géologie.

At head of title: Accord de la science et de la religion.

Accord des sciences naturelles avec les récits de Moise : et en particulier accord des phénomènes géologiques et de la Bible sur la date du déluge /

At head of title page: Thèse Publiquement Soutenue dans la Faculté de Théologie Protestante de Montauban.

Sündflut : nebst drei anderen der wichtigsten Episoden des Mahâ-Bhârata.

Mode of access: Internet.

Neue Theorie von der Entstehung der Gänge : mit Anwendung auf den Bergbau besonders den freibergischen /

Goldsmiths'-Kress no. 15057.6, suppl.

Documens hiéroglyphiques, emportés d'Assyrie, et conservés en Chine et en Amérique, sur le déluge de Noé, les dix générations avant le déluge, l'existence d'un premier homme, et celle du péché original: dogmes qui sont la base du christianisme, mais qui sont niés en ce jour,

"Pièces justificatives, textes et annotations relatives au mémoire précédent, sur le déluge": p. 41-56.

Rozbiór krytyczny zasad historyi o pocza̜tkach rodu ludzkiego /

Half-title, and binder's title, v. 3.: Badania historyczne.

The sacred theory of the earth : containing an account of the original of the earth, and of all the general changes which it hath already undergone, or is to undergo, till the consummation of all things.

First published 1681-89 in Latin under the title: Telluris theoria sacra.

A World without Causation: Big Data and the Coming of Age of Posthumanism

Advocates of Big Data assert that we are in the midst of an epistemological revolution, promising the displacement of the modernist methodological hegemony of causal analysis and theory generation. It is alleged that the growing ‘deluge’ of digitally generated data, and the development of computational algorithms to analyse them, has enabled new inductive ways of accessing everyday relational interactions through their ‘datafication’. This paper critically engages with these discourses of Big Data and complexity, particularly as they operate in the discipline of International Relations, where it is alleged that Big Data approaches have the potential for developing self-governing societal capacities for resilience and adaptation through the real-time reflexive awareness and management of risks and problems as they arise. The epistemological and ontological assumptions underpinning Big Data are then analysed to suggest that critical and posthumanist approaches have come of age through these discourses, enabling process-based and relational understandings to be translated into policy and governance practices. The paper thus raises some questions for the development of critical approaches to new posthuman forms of governance and knowledge production.

A novel hybrid swarm based approach for curriculum based course timetabling problem

This work applies a hybrid approach in solving the university curriculum-based course timetabling problem as presented as part of the 2nd International Timetabling Competition 2007 (ITC2007). The core of the hybrid approach is based on an artificial bee colony algorithm. Past methods have applied artificial bee colony algorithms to university timetabling problems with high degrees of success. Nevertheless, there exist inefficiencies in the associated search abilities in term of exploration and exploitation. To improve the search abilities, this work introduces a hybrid approach entitled nelder-mead great deluge artificial bee colony algorithm (NMGD-ABC) where it combined additional positive elements of particle swarm optimization and great deluge algorithm. In addition, nelder-mead local search is incorporated into the great deluge algorithm to further enhance the performance of the resulting method. The proposed method is tested on curriculum-based course timetabling as presented in the ITC2007. Experimental results reveal that the proposed method is capable of producing competitive results as compared with the other approaches described in literature

Strategic Alert Throttling for Intrusion Detection Systems

Network intrusion detection systems are themselves becoming targets of attackers. Alert flood attacks may be used to conceal malicious activity by hiding it among a deluge of false alerts sent by the attacker. Although these types of attacks are very hard to stop completely, our aim is to present techniques that improve alert throughput and capacity to such an extent that the resources required to successfully mount the attack become prohibitive. The key idea presented is to combine a token bucket filter with a realtime correlation algorithm. The proposed algorithm throttles alert output from the IDS when an attack is detected. The attack graph used in the correlation algorithm is used to make sure that alerts crucial to forming strategies are not discarded by throttling.