Matemática y química, ¿una integración posible?

Con la finalidad de establecer vínculos entre distintas áreas del conocimiento, se propone utilizar herramientas de la matemática e informática en una clase de Química de Escuela Secundaria Técnica. Se proponen distintas formas para procesar la información disponible. Se analiza el impacto de esta propuesta en los alumnos participantes. El trabajo realizado muestra lo escasamente significativo que resultan ciertos tratamientos de temas en matemática sin aplicación a situaciones específicas y de cómo se puede modificar esta realidad teniendo en cuenta que un conocimiento sólo será transformado en objeto matemático cuando previamente pueda utilizarse como herramienta de resolución, para luego ser reutilizado

β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function

The β1-integrin cytoplasmic domain consists of a membrane proximal subdomain common to the four known isoforms (“common” region) and a distal subdomain specific for each isoform (“variable” region). To investigate in detail the role of these subdomains in integrin-dependent cellular functions, we used β1A and β1B isoforms as well as four mutants lacking the entire cytoplasmic domain (β1TR), the variable region (β1COM), or the common region (β1ΔCOM-B and β1ΔCOM-A). By expressing these constructs in Chinese hamster ovary and β1 integrin-deficient GD25 cells (Wennerberg et al., J Cell Biol 132, 227–238, 1996), we show that β1B, β1COM, β1ΔCOM-B, and β1ΔCOM-A molecules are unable to support efficient cell adhesion to matrix proteins. On exposure to Mn++ ions, however, β1B, but none of the mutants, can mediate cell adhesion, indicating specific functional properties of this isoform. Analysis of adhesive functions of transfected cells shows that β1B interferes in a dominant negative manner with β1A and β3/β5 integrins in cell spreading, focal adhesion formation, focal adhesion kinase tyrosine phosphorylation, and fibronectin matrix assembly. None of the β1 mutants tested shows this property, indicating that the dominant negative effect depends on the specific combination of common and B subdomains, rather than from the absence of the A subdomain in the β1B isoform.

Mutual recognition, unemployment and the welfare state. Bruges European Economic Policy (BEEP) Briefing 3/2003

No abstract.

The 2005 Reform of the Stability and Growth Pact: Too Little, Too Late? Bruges European Economic Research (BEER) Papers 6/November 2006

This paper analyses the main critiques addressed by the literature and the policymakers to the 1997 Stability and Growth Pact. It further indicates to what extent the 2005 reform of the Pact meets those critics. It finally argues that the 2005 reform may be too little and arrive too late to restore the Pact credibility, ensure its enforceability and correctly set the derogations to the excessive deficit procedure on the nature of the shocks which cause the output gap rather than its size: a 3% of GDP limit on deficit spending may be a too binding constraint in front of a strongly negative demand shock, while it is irrationally large in front of a supply shock. Some empirical evidence is provided to identify in the last years strongly negative demand shocks from other shocks in the 25 EU Member States. Had this identifying method been adopted in November 2003, the European Commission and the Council would have both agreed to stop the excessive deficit procedure against Germany, but they would have both proceeded against France which apparently was not at the time hit by a strongly negative demand shock.

De summo bono /

Liber VI, Tractatus 3, capitulus 6 is the last known part of De summo bono--Liber VI, p. vii.

Notas de Población Vol. 43 N° 102

La edición núm. 102 de Notas de Población llega a los lectores con un diverso catálogo de temas de suma importancia en el campo de los estudios demográficos y de la población de América Latina y el Caribe. Estos temas, que se analizan a lo largo de los 12 artículos que conforman este volumen, abarcan resumidamente los censos y las proyecciones de población, el análisis de la fecundidad en relación con las características de las uniones, el derecho a la salud de las personas de edad, el envejecimiento demográfico en el Brasil, las formas de convivencia de los latinoamericanos en España, la migración uruguaya de retorno desde aquel país europeo, el proceso de urbanización en el Brasil, la segregación espacial en ciudades mineras de Chile, la movilidad laboral femenina en México, el impacto de la explotación minero-energética en Colombia, los rostros diversificados del envejecimiento en el Brasil y las interrelaciones entre escolaridad, estrato social y formación de la unión en México.

Cambios y continuidades en la movilidad laboral de la fuerza de trabajo femenina en México

Este artículo tiene por objeto analizar diferentes transiciones laborales de mujeres mexicanas de tres generaciones, desde su primer empleo hasta los 30 años. La finalidad es doble: por una parte, observar procesos de informalización, descalificación, desalarización y tercerización del mercado de trabajo femenino en los últimos años, y, por la otra, analizar en qué medida estos procesos se manifiestan en la movilidad individual de las trayectorias laborales femeninas. En primer término, los hallazgos indicarían que los cambios generacionales asociados a las transiciones laborales en el sector de actividad, la posición en el empleo, el estatus ocupacional y la rama de la economía no son procesos intercambiables. En segundo lugar, reflejarían que las movilidades estructurales del mercado de trabajo no se corresponden, punto por punto, con las movilidades individuales de la fuerza de trabajo femenina. Los resultados también dan cuenta de que las condiciones de entrada al mercado laboral tienen gran incidencia en las posibilidades futuras de las trayectorias laborales de las mujeres.

An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples

Lipid peroxidation products like malondialdehyde, 4-hydroxynonenal and F(2)-isoprostanes are widely used as markers of oxidative stress in vitro and in vivo. This study reports the results of a multi-laboratory validation study by COST Action B35 to assess inter-laboratory and intra-laboratory variation in the measurement of lipid peroxidation. Human plasma samples were exposed to UVA irradiation at different doses (0, 15 J, 20 J), encoded and shipped to 15 laboratories, where analyses of malondialdehyde, 4-hydroxynonenal and isoprostanes were conducted. The results demonstrate a low within-day-variation and a good correlation of results observed on two different days. However, high coefficients of variation were observed between the laboratories. Malondialdehyde determined by HPLC was found to be the most sensitive and reproducible lipid peroxidation product in plasma upon UVA treatment. It is concluded that measurement of malondialdehyde by HPLC has good analytical validity for inter-laboratory studies on lipid peroxidation in human EDTA-plasma samples, although it is acknowledged that this may not translate to biological validity.

The impact of ageing and gender on visual mental imagery processes:a study of performance on tasks from the Complete Visual Mental Imagery Battery (CVMIB)

In this study we aim to evaluate the impact of ageing and gender on different visual mental imagery processes. Two hundred and fifty-one participants (130 women and 121 men; age range = 18–77 years) were given an extensive neuropsychological battery including tasks probing the generation, maintenance, inspection, and transformation of visual mental images (Complete Visual Mental Imagery Battery, CVMIB). Our results show that all mental imagery processes with the exception of the maintenance are affected by ageing, suggesting that other deficits, such as working memory deficits, could account for this effect. However, the analysis of the transformation process, investigated in terms of mental rotation and mental folding skills, shows a steeper decline in mental rotation, suggesting that age could affect rigid transformations of objects and spare non-rigid transformations. Our study also adds to previous ones in showing gender differences favoring men across the lifespan in the transformation process, and, interestingly, it shows a steeper decline in men than in women in inspecting mental images, which could partially account for the mixed results about the effect of ageing on this specific process. We also discuss the possibility to introduce the CVMIB in clinical assessment in the context of theoretical models of mental imagery.

Data compilation on the biological response to ocean acidification: environmental and experimental context of data sets and related literature

The exponential growth of studies on the biological response to ocean acidification over the last few decades has generated a large amount of data. To facilitate data comparison, a data compilation hosted at the data publisher PANGAEA was initiated in 2008 and is updated on a regular basis (doi:10.1594/PANGAEA.149999). By January 2015, a total of 581 data sets (over 4 000 000 data points) from 539 papers had been archived. Here we present the developments of this data compilation five years since its first description by Nisumaa et al. (2010). Most of study sites from which data archived are still in the Northern Hemisphere and the number of archived data from studies from the Southern Hemisphere and polar oceans are still relatively low. Data from 60 studies that investigated the response of a mix of organisms or natural communities were all added after 2010, indicating a welcomed shift from the study of individual organisms to communities and ecosystems. The initial imbalance of considerably more data archived on calcification and primary production than on other processes has improved. There is also a clear tendency towards more data archived from multifactorial studies after 2010. For easier and more effective access to ocean acidification data, the ocean acidification community is strongly encouraged to contribute to the data archiving effort, and help develop standard vocabularies describing the variables and define best practices for archiving ocean acidification data.

Awareness and Learning in Participatory Noise Sensing

The development of ICT infrastructures has facilitated the emergence of new paradigms for looking at society and the environment over the last few years. Participatory environmental sensing, i.e. directly involving citizens in environmental monitoring, is one example, which is hoped to encourage learning and enhance awareness of environmental issues. In this paper, an analysis of the behaviour of individuals involved in noise sensing is presented. Citizens have been involved in noise measuring activities through the WideNoise smartphone application. This application has been designed to record both objective (noise samples) and subjective (opinions, feelings) data. The application has been open to be used freely by anyone and has been widely employed worldwide. In addition, several test cases have been organised in European countries. Based on the information submitted by users, an analysis of emerging awareness and learning is performed. The data show that changes in the way the environment is perceived after repeated usage of the application do appear. Specifically, users learn how to recognise different noise levels they are exposed to. Additionally, the subjective data collected indicate an increased user involvement in time and a categorisation effect between pleasant and less pleasant environments.