[Lettre autographe signée de Beurtez-Delancourt à Monsieur d'Etilly, Versailles, 20 janvier 1821]

Au sujet de Mademoiselle Duchesnois

Mémoire sur l'anatomie des tumeurs érectiles / par M. le docteur Charles Robin,.... [suivi d'une Observation d'une fracture de l'apophyse zygomatique...] / [par M. Hiffelsheim]

Comprend : Observation d'une fracture de l'apophyse zygomatique...

Relação entre poesia e prosa de Charles Baudelaire

Pós-graduação em Estudos Literários - FCLAR

Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels.

BACKGROUND Cavalier King Charles Spaniels (CKCS) have a high prevalence of inherited macrothrombocytopenia. The purpose of this study was to determine if a mutation in beta1-tubulin correlated with presumptive inherited macrothrombocytopenia. HYPOTHESIS A mutation in beta1-tubulin results in synthesis of an altered beta1-tubulin monomer. alpha-beta tubulin dimers within microtubule protofilaments are unstable, resulting in altered megakaryocyte proplatelet formation. ANIMALS Blood samples were obtained from CKCS and non-CKCS dogs. METHODS DNA was used in polymerase chain reaction (PCR) assays to evaluate beta1-tubulin. Platelet numbers and mean platelet volume (MPV) were evaluated for a correlation with the presence or absence of a mutation identified in beta1-tubulin. Platelets obtained from homozygous, heterozygous, and clear CKCS were further evaluated using electron microscopy and immunofluorescence. RESULTS A mutation in the gene encoding beta1-tubulin correlated with macrothrombocytopenia in CKCS. Electron microscopy and immunofluorescence studies suggest that platelet microtubules are present but most likely are unstable and decreased in number. CONCLUSIONS AND CLINICAL IMPORTANCE The macrothrombocytopenia of CKCS correlated with a mutation in beta1-tubulin. alpha-beta tubulin dimers within protofilaments most likely are unstable, leading to altered proplatelet formation by megakaryocytes. This information will aid in distinguishing inherited from acquired thrombocytopenia. It also provides insight into the mechanism of platelet production by megakaryocytes, and also may prove useful in understanding heart-related changes in macrothrombocytopenic CKCS with concurrent mitral valve regurgitation.

Payment order for Phillips Payson on behalf of his son, 1777 July 1

Handwritten order to John Sale to pay scholarship funds to Phillips Payson for use by his son, signed by Charles Chauncey and Jonathan Williams.

X. Harvard College Papers, 1st series, Volume 10, 1821-1824, 1831

The tenth volume of College Papers contains original documents dating from 1821 to 1824, spanning the tenures of president John Thornton Kirkland and treasurer John Davis. Much of the volume consists of general administrative correspondence exchanged between Kirkland and Davis, as well as correspondence between Davis and Steward Stephen Higginson. It also contains a printed document from 1831, during the tenure of president Josiah Quincy.

IX. Harvard College Papers, 1st series, Volume 9, 1819-1821

The ninth volume of College Papers contains original documents dating from 1819 to 1821, spanning the tenures of president John Thornton Kirkland and treasurer John Davis, as well as correspondence between Davis and Steward Stephen Higginson. Much of the volume consists of general administrative correspondence exchanged between Kirkland and Davis. It also contains an early 20th century typewritten document.

IX. Harvard College Papers, 1st series, Volume 9, 1819-1821

The ninth volume of College Papers contains original documents dating from 1819 to 1821, spanning the tenures of president John Thornton Kirkland and treasurer John Davis, as well as correspondence between Davis and Steward Stephen Higginson. Much of the volume consists of general administrative correspondence exchanged between Kirkland and Davis. It also contains an early 20th century typewritten document.

X. Harvard College Papers, 1st series, Volume 10, 1821-1824, 1831

The tenth volume of College Papers contains original documents dating from 1821 to 1824, spanning the tenures of president John Thornton Kirkland and treasurer John Davis. Much of the volume consists of general administrative correspondence exchanged between Kirkland and Davis, as well as correspondence between Davis and Steward Stephen Higginson. It also contains a printed document from 1831, during the tenure of president Josiah Quincy.

Narragansett Bay, Rhode Island, 1777 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A topographical chart of the bay of Narraganset in the province of New England : with all the isles contained therein, among which Rhode Island and Connonicut have been particularly surveyed, shewing the true position & bearings of the banks, shoals, rocks &c. as likewise the soundings, to which have been added the several works & batteries raised by the Americans, taken by order of the principal farmers on Rhode Island, by Charles Blaskowitz. It was published in 1777 by Wm. Faden. Scale [ca. 1:50,000]. Nautical chart showing American Revolution military defenses and points of interest. Covers the Narraganset Bay region, Rhode Island. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Rhode Island State Plane Coordinate System (Feet) (FIPS 3800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, selected buildings, farms, military defenses and structures, drainage, and more. Relief shown by hachures. Depths shown by soundings and form lines. Includes text, "References to the batteries," and "A list of the principal farms in Rhode Island." This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.