Cantor lectures on the modern methods of artificial illumination : delivered before the Royal Society of Arts on February 15, 22, and March 1 and 8, 1909 /

Mode of access: Internet.

Memorial meeting: Israel Friedlaender, Bernard Cantor whose lives were sacrificed July 5, 1920 in the cause of Israel ...

Mode of access: Internet.

El práctico cantor en el ministerio de la iglesia : obra de canto-llano y figurado, útil y necesaria, para el estado eclesiástico ... /

Mode of access: Internet.

CONSTRUÇÕES IMAGINÁRIAS NO CONTEXTO DE UM FENÔMENO MUSICAL DE MASSA: O CASO DO CANTOR MICHEL TELÓ

Estudo sobre o processo de construção imaginária do público de gênero feminino ao consumir os produtos dos fenômenos musicais de massa, no Brasil. Tendo como base o caso do sucesso do cantor Michel Teló, representante do gênero musical sertanejo universitário, o objetivo é compreender o processo de construção imaginária que permeia a relação do público feminino (fãs) e consumo do gênero musical sertanejo universitário, a partir do discurso do cantor Michel Teló. Para tal, será tomado referencial teórico do campo dos Estudos Culturais em diálogo com estudos sobre imaginário e música de massa. A análise do discurso, de linha francesa, é a metodologia empregada em duas instâncias para se testar as reflexões construídas com a base teórica: a priori, a partir de um processo de observação participante, durante um espetáculo do artista, em que será observada a interação entre fenômeno e público, no momento de execução da sua música Ai, se eu te pego! ; e, doravante, o discurso do músico é analisado, por meio de entrevistas realizadas em programas televisivos. Um questionário aplicado a uma amostra entre o público feminino apreciador do cantor e de suas músicas contribui ainda no aprofundamento da reflexão. Resulta desta pesquisa a compreensão da proeminência do discurso ao conteúdo. Desta maneira, a importância maior se encontra na forma com que o cantor dialoga com seu público, por meio da imagem que ele constrói em torno de si.

CONSTRUÇÕES IMAGINÁRIAS NO CONTEXTO DE UM FENÔMENO MUSICAL DE MASSA: O CASO DO CANTOR MICHEL TELÓ

Estudo sobre o processo de construção imaginária do público de gênero feminino ao consumir os produtos dos fenômenos musicais de massa, no Brasil. Tendo como base o caso do sucesso do cantor Michel Teló, representante do gênero musical sertanejo universitário, o objetivo é compreender o processo de construção imaginária que permeia a relação do público feminino (fãs) e consumo do gênero musical sertanejo universitário, a partir do discurso do cantor Michel Teló. Para tal, será tomado referencial teórico do campo dos Estudos Culturais em diálogo com estudos sobre imaginário e música de massa. A análise do discurso, de linha francesa, é a metodologia empregada em duas instâncias para se testar as reflexões construídas com a base teórica: a priori, a partir de um processo de observação participante, durante um espetáculo do artista, em que será observada a interação entre “fenômeno” e público, no momento de execução da sua música “Ai, se eu te pego!”; e, doravante, o discurso do músico é analisado, por meio de entrevistas realizadas em programas televisivos. Um questionário aplicado a uma amostra entre o público feminino apreciador do cantor e de suas músicas contribui ainda no aprofundamento da reflexão. Resulta desta pesquisa a compreensão da proeminência do discurso ao conteúdo. Desta maneira, a importância maior se encontra na forma com que o cantor dialoga com seu público, por meio da imagem que ele constrói em torno de si.

Relações de alteridade: dor e hospitalidade no romance colombiano La ceiba de la memoria, de Roberto Burgos Cantor

Esta dissertação pretende fazer uma leitura analítica, pelo viés ético, do romance histórico colombiano La ceiba de la memoria (2007), de Roberto Burgos Cantor. A pesquisa do romance terá a base teórica de três filósofos: Emmanuel Lévinas, com Totalidade e Infinito (1971) e a sua ideia de alteridade e a ética como filosofia primeira; Jacques Derrida, com Da Hospitalidade (2003) e o seu princípio de hospitalidade e Hannah Arendt, com base em A condição humana (1958) e o desenvolvimento da ideia do labor, que ela realiza nesta obra. O resultado será uma análise comparada, entre literatura e filosofia, que aprofundará a condição dos personagens escravizados no universo narrativo da obra literária, por intermédio dos conceitos filosóficos de alteridade-hospitalidade-labor, principalmente.

The Effects of Commercially Available Preservative-Free FDA-Approved Triamcinolone (Triesence (R)) on Retinal Cells in Culture

Purpose: To evaluate the effects of Triesence (R) (TRI), a new preservative-free triamcinolone approved by the U. S. Food and Drug Administration (FDA) for intraocular use, on human retina pigment epithelial (ARPE-19) and rat neurosensory (R28) cells in culture. Methods: ARPE-19 and R28 cell cultures were treated 24 h with 1,000, 500, 200, or 100 mu g/mL of crystalline (cTRI) or 1,000, 500, or 200 mu g/mL of solubilized (sTRI). TRI was solubilized by centrifuging the drug, discarding the supernatant containing the vehicle and then resuspending the drug pellet in an equivalent amount of Dimethyl sulfoxide to achieve the same concentration as the commercial preparation. Percentage of cell viability (CV) was evaluated by a trypan blue dye-exclusion assay. The mitochondrial membrane potential (Delta Psi m) was analyzed with the JC-1 assay. The caspase-3/7 activity was measured by a fluorochrome assay. Results: In the ARPE-19 cultures, the cTRI caused a decrease in CV at 1,000 mg/mL (13.03 +/- 6.51; P < 0.001), 500 mu g/mL (28.87 +/- 9.3; P < 0.001), 200 mu g/mL (54.93 +/- 5.61; P < 0.001), and 100 mu g/mL (82.53 +/- 0.65; P < 0.005) compared with the untreated controls (96.98 +/- 0.16). In R28 cultures, the cTRI treatment also reduced CV values significantly (P < 0.001) for the 1,000 mu g/mL (22.73 +/- 2.44), 500 mu g/mL (34.63 +/- 1.91), 200 mu g/mL (58.70 +/- 1.39), and 100 mu g/m (75.33 +/- 2.47) compared with the untreated controls (86.08 +/- 3.54). Once the TRI was solubilized (sTRI), the CV and Delta Psi m remained similar to the untreated controls for both ARPE-19 and R28 cells. The sTRI treatment with 1,000, 500, and 200 mu g/mL increased in caspase-3/7 activity in ARPE-19 cells (P < 0.01) and in R28 cells (P < 0.05) compared with dimethyl sulfoxide equivalent controls. Conclusion: The crystalline form of TRI (cTRI) can cause a significant decrease in CV to cultured retinal cells. Once the TRI is solubilized (sTRI), at the same concentrations, the cells remain viable with no decrease in CV or Delta Psi m. The sTRI can, however, increase caspase-3/7 activity, thus suggesting some degree of apoptosis.

AFFINE INTERVAL EXCHANGE TRANSFORMATIONS WITH FLIPS AND WANDERING INTERVALS

There exist uniquely ergodic affine interval exchange transformations of [0,1] with flips which have wandering intervals and are such that the support of the invariant measure is a Cantor set.

Process Capability Indexes Determination on Tabletting Performance during the Process Validation for Metamizol Tablets

The aim of the present study was to provide a numerical measure, through the process capability indexes (PCIs), C(p) and C(pk), on whether or not the manufacturing process can be considered capable of producing metamizol (500 mg) tablets. They were also used as statistical tool in order to prove the consistency of the tabletting process, making sure that the tablet weight and the content uniformity of metamizol are able to comply with the preset requirements. Besides that, the ANOVA, the t-test and the test for equal variances were applied to this study, allowing additional knowledge of the tabletting phase. Therefore, the proposed statistical approach intended to assure more safety, precision and accuracy on the process validation analysis.

Optimization of preservative system in ophthalmic suspension with dexamethasone and polymyxin B

A simplex-lattice statistical project was employed to study an optimization method for a preservative system in an ophthalmic suspension of dexametasone and polymyxin B. The assay matrix generated 17 formulas which were differentiated by the preservatives and EDTA (disodium ethylene diamine-tetraacetate), being the independent variable: X-1 = chlorhexidine digluconate (0.010 % w/v); X-2 = phenylethanol (0.500 % w/v); X-3 = EDTA (0.100 % w/v). The dependent variable was the Dvalue obtained from the microbial challenge of the formulas and calculated when the microbial killing process was modeled by an exponential function. The analysis of the dependent variable, performed using the software Design Expert/W, originated cubic equations with terms derived from stepwise adjustment method for the challenging microorganisms: Pseudomonas aeruginosa, Burkholderia cepacia, Staphylococcus aureus, Candida albicans and Aspergillus niger. Besides the mathematical expressions, the response surfaces and the contour graphics were obtained for each assay. The contour graphs obtained were overlaid in order to permit the identification of a region containing the most adequate formulas (graphic strategy), having as representatives: X-1 = 0.10 ( 0.001 % w/v); X-2 = 0.80 (0.400 % w/v); X-3 = 0.10 (0.010 % w/v). Additionally, in order to minimize responses (Dvalue), a numerical strategy corresponding to the use of the desirability function was used, which resulted in the following independent variables combinations: X-1 = 0.25 (0.0025 % w/v); X-2 = 0.75 (0.375 % w/v); X-3 = 0. These formulas, derived from the two strategies (graphic and numerical), were submitted to microbial challenge, and the experimental Dvalue obtained was compared to the theoretical Dvalue calculated from the cubic equation. Both Dvalues were similar to all the assays except that related to Staphylococcus aureus. This microorganism, as well as Pseudomonas aeruginosa, presented intense susceptibility to the formulas independently from the preservative and EDTA concentrations. Both formulas derived from graphic and numerical strategies attained the recommended criteria adopted by the official method. It was concluded that the model proposed allowed the optimization of the formulas in their preservation aspect.

Bioequivalence Evaluation of Two Different Tablet Formulations of Tinidazole in Healthy Volunteers

The bioequivalence of two different tablet formulations of tirtidazole (CAS 19387-91-8) was determined in healthy volunteers after a single dose in a randomized crossover study, with a 1-week washout period between the doses. Reference and test products were administered to 24 volunteers with 240 mL water after overnight fasting. Plasma concentrations of tinidazole were monitored by a high-performance liquid chromatographic method (HPLC) over a period of 72 h after the administration. The pharmacokinetic parameters AUC(0-t), AUC(0-infinity), C(max), T(max), T((1/2)el) and beta were determined from plasma concentration time profile of both formulations and found to be in good agreement with previously reported values. The calculated pharmacokinetic parameters were compared statistically to evaluate bioequivalence between the two brands. The analysis of variance (ANOVA) did not show any significant difference between the two formulations and 90% confidence intervals for the ratio of C(max) (93.9 - 102.6%), AUC(0-t), (94.9-101.1%) and AUC(0-infinity) (94.6-100.8%) values for the test and reference products were within the 80 - 125% interval, satisfying bioequivalence criteria of the European Committee for Proprietary Medicinal Products and the US Food and Drug Administration Guidelines. These results indicate that the test and the reference products of tinidazole are bioequivalent and, thus, may be prescribed interchangeably.

Bioequivalence study of two oral formulations of cefadroxil in healthy volunteers

Two different cefadroxil (CAS 50370-12-2) formulations were evaluated for their relative bioavailability in 24 healthy volunteers who received a single 500 mg oral dose of each preparation. An open, randomized clinical trial designed as a two-period crossover study with a 7-day washout period between doses was employed. Plasma samples for assessments of their cefadroxil concentration by HPLC-UV were obtained over 8 h after administration. Values of 48.94 +/- 10.18 mu g . h/ml for test, and 48.51 +/- 9.02 mu g . h/ml for the reference preparation AUC(0-t) demonstrate a nearly identical extend of drug absorption. Maximum plasma concentration C-max of 16.04 +/- 4.94 mu g/ml and 16.01 +/- 4.02 mu g/ml achieved for the test and reference preparations did not differ significantly. The parametric 90% confidence intervals (CI) of the mean of the difference (test-reference) between log-transformed values of the two formulations were 96.80% to 104.51% and 92.01% to 107.00% for AUC(0-t) and C-max, respectively. Since for both AUC(0-t) or C-max the 90% CI values are within the interval proposed by the Food and Drug Administration, the test product is bioequivalent to the reference product for both the rate and extent of absorption after single dose administration.