Les polymorphismes des gènes encodant les protéines apoptotiques Bim et Bax : leur rôle dans la réponse thérapeutique chez les enfants ayant la leucémie lymphoblastique aiguë

INTRODUCTION Des réponses thérapeutiques variables aux glucocorticoïdes (GCs) sont observées parmi les patients atteints de la leucémie lymphoblastique aiguë (LLA). Les protéines Bax et Bim ont déjà montré un rôle important dans l’apoptose des cellules leucémiques. L’expression de Bax était plus basse chez les patients leucémiques résistants au médicament, de même une sensibilité diminuée aux GCs a été associée avec une expression réduite de Bim. La différence dans l’expression pourrait être due à des polymorphismes présents dans ces gènes et donc être associés avec la résistance aux GCs. MÉTHODE Dix-huit polymorphismes en régions régulatrices, 2 polymorphismes exoniques et 7 polymorphismes en région 3’UTR de ces gènes ont été analysés chez les témoins (n=50) et ont permis de déterminer un nombre minimal de polymorphismes suffisants pour définir les haplotypes (tagSNPs). Ces 8 polymorphismes ont ensuite été génotypés chez 286 enfants atteints de la LLA et ont été testés pour l’issue de la maladie par l’analyse de survie. RÉSULTATS Une survie sans évènement et une survie sans rechute diminuées ont été observées pour l’haplotype 3 (p=0,03 et p=0,02). Une survie globale diminuée a été associée avec l’homozygotie pour l’allèle exonique T298C>T (p=0,03), de même que pour les haplotypes 1 et 4 (p=0,04 et p=0,02) du gène Bim. CONCLUSION Les polymorphismes ont été associés avec une survie diminuée chez des enfants atteints de LLA. Il reste à tester d’autres polymorphismes présents dans ces deux gènes ainsi qu’à définir leurs fonctions afin de comprendre leurs rôles dans la réponse aux GCs.

Análisis de la evolución en las prácticas de Mejoramiento Integral de Barrios (BIM) en la Gestión Urbana de Bogotá entre 1995-2011

La ciudad informal en las periferias urbanas ha sido una de las mayores preocupaciones de las grandes ciudades latinoamericanas. Distintos enfoques a este problema han derivado en distintas formas de abordarlo a partir de la política pública. En el caso de Bogotá, los Programas de Mejoramiento Integral han permitido visibilizar, intervenir e integrar grandes porciones de suelo objeto de procesos de urbanizaciones incompletas, dando solución a miles de familias que han tenido que asentarse de forma emergente y bajo condiciones urbanas muy precarias. De hecho, Bogotá se ha convertido en una referencia nacional e internacional sobre la forma en que se ha implementado este tipo de programa. Sin embargo, al hacer un repaso sobre las enseñanzas que ha dejado esta experiencia, se encuentra información pública limitada y se evidencia una pérdida de la memoria institucional sobre su operación y resultados.

Implementing ‘Site BIM’: a case study of ICT innovation on a large hospital project

Numerous Building Information Modelling (BIM) tools are well established and potentially beneficial in certain uses. However, issues of adoption and implementation persist, particularly for on-site use of BIM tools in the construction phase. We describe an empirical case-study of the implementation of an innovative ‘Site BIM’ system on a major hospital construction project. The main contractor on the project developed BIM-enabled tools to allow site workers using mobile tablet personal computers to access design information and to capture work quality and progress data on-site. Accounts show that ‘Site BIM’, while judged to be successful and actively supporting users, was delivered through an exploratory and emergent development process of informal prototyping. Technical IT skills were adopted into the construction project through personal relationships and arrangements rather than formal processes. Implementation was driven by construction project employees rather than controlled centrally by the corporate IT function.

BIM: innovation in design management, influence and challenges of implementation

The construction industry is widely being criticised as a fragmented industry. There are mounting calls for the industry to change. The espoused change calls for collaboration as well as embracing innovation in the process of design, construction and across the supply chain. Innovation and the application of emerging technologies are seen as enablers for integrating the processes ‘integrating the team’ such as building information modelling (BIM). A questionnaire survey was conducted to ascertain change in construction with regard to design management, innovation and the application of BIM as cutting edge pathways for collaboration. The respondents to the survey were from an array of designations across the construction industry such as construction managers, designers, engineers, design coordinators, design managers, architects, architectural technologists and surveyors. There was a general agreement by most respondents that the design team was responsible for design management in their organisation. There is a perception that the design manager and the client are the catalyst for advancing innovation. The current state of industry in terms of incorporating BIM technologies is posing a challenge as well as providing an opportunity for accomplishment. BIM technologies provide a new paradigm shift in the way buildings are designed, constructed and maintained. This paradigm shift calls for rethinking the curriculum for educating building professionals, collectively.

Interactive learning in UK construction practice: examining the role of BIM process standards

From a construction innovation systems perspective, firms acquire knowledge from suppliers, clients, universities and institutional environment. Building information modelling (BIM) involves these firms using new process standards. To understand the implications on interactive learning using BIM process standards, a case study is conducted with the UK operations of a multinational construction firm. Data is drawn from: a) two workshops involving the firm and a wider industry group, b) observations of practice in the BIM core team and in three ongoing projects, c) 12 semi-structured interviews; and d) secondary publications. The firm uses a set of BIM process standards (IFC, PAS 1192, Uniclass, COBie) in its construction activities. It is also involved in a pilot to implement the COBie standard, supported by technical and management standards for BIM, such as Uniclass and PAS1192. Analyses suggest that such BIM process standards unconsciously shapes the firm's internal and external interactive learning processes. Internally standards allow engineers to learn from each through visualising 3D information and talking around designs with operatives to address problems during construction. Externally, the firm participates in trial and pilot projects involving other construction firms, government agencies, universities and suppliers to learn about the standard and access knowledge to solve its specific design problems. Through its BIM manager, the firm provides feedback to standards developers and information technology suppliers. The research contributes by articulating how BIM process standards unconsciously change interactive learning processes in construction practice. Further research could investigate these findings in the wider UK construction innovation system.

Metodologia BIM: uma nova abordagem, uma nova esperança

A metodologia BIM (Building Information Modeling), tem vindo a ganhar grande importância na indústria da AEC (Arquitetura, Engenharia e Construção). Este conceito introduz alterações muito significativas na forma como atualmente se aborda a conceção, construção e manutenção de edifícios. Apesar da emergente utilização, não existem neste momento normas de boas práticas para a sua implementação em Portugal. O BIM tem como princípios a integração das fases do processo construtivo, a integração e trabalho colaborativo de todas as especialidades envolvidas na fase de projeto, sendo apoiada por aplicações de visualização tridimensional. O grande potencial do conceito BIM está também na normalização da informação, sendo suportada entre outros aspetos na normalização da forma como se devem modelar os objetos. Assente nesta base são várias as potencialidades que daqui decorrem. No âmbito desta dissertação pretende-se abordar e aplicar a metodologia BIM ao projeto de estruturas e de especialidades que foi previamente elaborado segundo a metodologia tradicional (CAD 2D). Pretende-se, clarificar a metodologia BIM e avaliar algumas das ferramentas computacionais disponíveis no mercado. O caso de estudo da presente dissertação, permitiu identificar algumas dificuldades e falhas existentes nos projetos a 2D, o que não acontece no caso da metodologia BIM.

Metodologia BIM: uma nova abordagem, uma nova esperança

A metodologia BIM (Building Information Modeling), tem vindo a ganhar grande importância na indústria da AEC (Arquitetura, Engenharia e Construção). Este conceito introduz alterações muito significativas na forma como atualmente se aborda a conceção, construção e manutenção de edifícios. Apesar da emergente utilização, não existem neste momento normas de boas práticas para a sua implementação em Portugal. O BIM tem como princípios a integração das fases do processo construtivo, a integração e trabalho colaborativo de todas as especialidades envolvidas na fase de projeto, sendo apoiada por aplicações de visualização tridimensional. O grande potencial do conceito BIM está também na normalização da informação, sendo suportada entre outros aspetos na normalização da forma como se devem modelar os objetos. Assente nesta base são várias as potencialidades que daqui decorrem. No âmbito desta dissertação pretende-se abordar e aplicar a metodologia BIM ao projeto de estruturas e de especialidades que foi previamente elaborado segundo a metodologia tradicional (CAD 2D). Pretende-se, clarificar a metodologia BIM e avaliar algumas das ferramentas computacionais disponíveis no mercado. O caso de estudo da presente dissertação, permitiu identificar algumas dificuldades e falhas existentes nos projetos a 2D, o que não acontece no caso da metodologia BIM.

Aplicação de ferramentas BIM em um projeto de cobertura do estádio Professor Dário Rodrigues Leite

In all segments, the companies are looking for the highest productivity with the lowest possible cost, and in the construction industry, the thinking is the same. Over time, techniques that generate more productivity supplanted previous techniques; an example is the CAD technology that replaced free drawings in projects execution. However, the Computer Aided Design (CAD) technology does not deal with certain factors that permeate the entire project. It is required the use of other techniques to supply this need in traditional projects. For example, a software for schedule management, another for assets management and a person who makes calculations for estimates and budgets. The BIM (Building Information Modeling) technology aims to integrate all this information, facilitating the communication among members of a work team and reducing the time required to carry out the project. This work is a applied research, a descriptive research, carried out through modeling and simulation, processes inherent in the use of BIM, a survey was also used only to contextualization. BIM was used for a soccer stadium roof project, in order to verify the feasibility of such use through the analysis of: BIM tools, difficulties encountered and implications of BIM use, and comparison of traditional methods and the use of BIM. To aid the contextualization, a survey was conducted to verify the use of BIM in medium and small companies

Aplicação de ferramentas BIM em um projeto de cobertura do estádio Professor Dário Rodrigues Leite

In all segments, the companies are looking for the highest productivity with the lowest possible cost, and in the construction industry, the thinking is the same. Over time, techniques that generate more productivity supplanted previous techniques; an example is the CAD technology that replaced free drawings in projects execution. However, the Computer Aided Design (CAD) technology does not deal with certain factors that permeate the entire project. It is required the use of other techniques to supply this need in traditional projects. For example, a software for schedule management, another for assets management and a person who makes calculations for estimates and budgets. The BIM (Building Information Modeling) technology aims to integrate all this information, facilitating the communication among members of a work team and reducing the time required to carry out the project. This work is a applied research, a descriptive research, carried out through modeling and simulation, processes inherent in the use of BIM, a survey was also used only to contextualization. BIM was used for a soccer stadium roof project, in order to verify the feasibility of such use through the analysis of: BIM tools, difficulties encountered and implications of BIM use, and comparison of traditional methods and the use of BIM. To aid the contextualization, a survey was conducted to verify the use of BIM in medium and small companies

El futuro de la profesión pasa por BIM

[ES]Presentación. BIM: Situación en el panorama nacional e internacional, Sergio Muñoz, Presidente de la BuildingSmart Spanish Chapter. ¿Qué BIM implantamos? Jesús Martínez, Arquitecto BIM Manager. BIM. Casos prácticos. Ciclo de vida de la edificación, Alejandro Núñez Noda, Director Técnico IMC Gestión Integral de la edificación. BG. BIM. Casos prácticos. Modelos BIM As-Built, Josep Coll, EiPM. BG. Smart Cities ¿Burbuja o Tendencia? Félix Herrera, responsable del Área de Ingeniería Telemática, Universidad de La Laguna. Láser Scaner 3D en la conservación del patrimonio y trabajo en grandes infraestructuras, Raúl Rubio, Captae. BG. Virtual BIM – Realidad Aumentada, Sergi Florensa, Virtual BIM.

Building Information Modelling (BIM) Effectiveness in Performing Life Cycle Assessment of Building

The scope of this project is to study the effectiveness of building information modelling (BIM) in performing life cycle assessment in a building. For the purposes of the study will be used “Revit” which is a BIM software and Tally which is an LCA tool integrated in Revit. The project is divided in six chapters. The first chapter consists of a theoretical introduction into building information modelling and its connection to life cycle assessment. The second chapter describes the characteristics of building information modelling (BIM). In addition, a comparison has been made with the traditional architectural, engineering and construction business model and the benefits to shift into BIM. In the third chapter it will be a review of the most well-known and available BIM software in the market. In chapter four life cycle assessment (LCA) will be described in general and later on specifically for the purpose of the case study that will be used in the following chapter. Moreover, the tools that are available to perform an LCA will be reviewed. Chapter five will present the case study that consists of a model in a BIM software (Revit) and the LCA performed by Tally, an LCA tool integrated into Revit. In the last chapter will be a discussion of the results that were obtained, the limitation and the possible future improvement in performing life cycle assessment (LCA) in a BIM model.