Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma

It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM.

24/12/19 Vel d'Hiv' départ du Bol d'or [les pistards : Georget, Van Neh, Deruyter, Godivier, Bartelemy, Léonard et Steux] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57305

25-12-19 Vel d'Hiv', Bol d'or [les pistards au repos] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57307

[25-12-19 Vel d'Hiv'] Barthelemy 4e, Georget vainqueur du Bol d'or, Godivier 2e : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57313

Le Travail et l'industrie de la construction, recherches et considérations sur leurs conditions économiques dans le passé, le présent et l'avenir, par P.-C.-M. Sauvage,... précédés d'une préface par M. Viollet-le-Duc

Comprend : Préface

Letter - E.C. Schmon to Arthur A. Schmon, 16 January 1919

The letter describes how Eleanor Celeste is a substitute teacher at this time. She also mentions a party held by her Uncle Dick in New York. Her uncle purchases a kewpie doll for her and each of the other girls worth six dollars. The letter is labelled number 216.

Letter - E.C. Schmon to Arthur A. Schmon, 16 February 1920

The letter begins with a description of the play "Three Wise Fools" that Eleanor Celeste attended at the Broad Theatre. She states it is "the best show that I have seen in years". She also talks about a garment she plans to make. The letter is labelled number 128.

Letter - E.C. Schmon to Arthur A. Schmon, 16 March 1918

The letter discusses a dress that she will have made and includes a fashion sketch with material done by Eleanore Celeste. She mentions going to the Fox Terminal Theatre to see the war picture "Lest We Forget". She later sees her friend Martha who has found out that her husband as been wounded via telegram from Washington. This letter is labelled number 71.

Letter - E.C. Schmon to Arthur A. Schmon, 16 September 1918

Eleanore Celeste mentions that planes were performing stunts and bands were playing so they made their way to Branch Brook Park to see the New Jersey State Militia Reserve. She also mentions plans to go to the movies and see "The Queen of the Sea" starring Annette Kellerman.

8AUG 6-D

Dark grey ground mass, with one other lighter domain. Both domains are extremely fine grained.