Progress: an episode in the history of hunger? Including also Mrs. Gardiner's receipts from 1763 and the Mount Hope electa of the nineteenth century; blandishments of life from the kitchen,

Bibliographical foot-notes.

The power of faith : exemplified in the life and writings of the late Mrs. Isabella Graham of New York.

The life of Mrs. Graham was written by her son-in-law Divie Bethune, and selections from her diary and letters were made by her daughter Joanna Graham Bethune.

Mrs. Gerald's niece : a novel /

Mode of access: Internet.

The complete works of Robert Burns : containing his poems, songs, and correspondence /

Added t.p.: Burns' complete works.

Memoirs of the late Mrs. Susan Huntington, of Boston, Mass. microform /

Checklist Amer. imprints

Lettres sur les peintures, sculptures et gravures de Mrs. de l'Académie royale : exposées au Sallon du Louvre depuis MDCCLXVII jusqu'en MDCCLXXIX /

Cicognara,

Prose works.

--v. 19 Periodical criticism:-v. 3, Miscellaneous: Tales of my landlord; Thornton's Sporting tour; Two cookery books; Johne's Translation of Froissart; Miseries of human life; Carr's Caledonian sketches; Lady Suffolk's correspondence; Kirkton's church history; Life & works of John Home.--v. 20 Periodical criticism:-v. 4 Miscellaneous: The Culloden papers; Pepy's Memoirs; Life of Kemble; Kelly's Reminiscences; Davy's Salmonia; Ancient history of Scotland.--v. 21 Periodical criticism:-v. 5 Miscellaneous: On planting waste lands--Monteath's Forester's guide; On landscape gardening--Sir H. Steuart's Planter's guide; Tytler's History of Scotland: Pitcairn's Criminal trials; Letters of Malachi Malagrowther on the currency.--v. 22-26 Tales of a grandfather: v. 1-5 Scotland.--v. 27-28 Tales of a grandfater: v. 6-7 France.

Trivial poems, and triolets. Written in obedience to Mrs. Tomkin's commands,

Edited from the original manuscript by Sir Walter Scott. cf. Introd.

Literature: I. Robert Burns. II. Sir Walter Scott. III. Lord Byron; from the Chicago record.

Mode of access: Internet.

The complete works of Mrs. Hemans /

Mode of access: Internet.

Ethyl-eicosapentaenoic acid in first-episode psychosis : a 1H-MRS study

Ethyl-eicosapentaenoic acid (E-EPA) is an omega-3 fatty acid that has been used in a range of neuropsychiatric conditions with some benefits. However, its mechanism of action is unknown. Here, we investigate its effects on in vivo brain metabolism in first-episode psychosis (FEP). Proton magnetic resonance spectroscopy at 3 T was performed in the temporal lobes of 24 FEP patients before and after 12 weeks of treatment in the context of a larger double-blind, placebo-controlled E-EPA augmentation study. Treatment group effects for glutathione (F1,12=6.1, p=0.03), and a hemisphere-by-group interaction for glutamine/glutamate (F1,20=4.4, p=0.049) were found. Glutathione increased bilaterally and glutamate/glutamine increased in the left hemisphere following E-EPA administration. Improvement in negative symptoms correlated with metabolic brain changes, particularly glutathione (r=-0.57). These results suggest that E-EPA augmentation alters glutathione availability and modulates the glutamine/glutamate cycle in early psychosis, with some of the metabolic brain changes being correlated with negative symptom improvement. Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted.

A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis

Schizophrenia is associated with significant brain abnormalities, including changes in brain metabolites as measured by proton magnetic resonance spectroscopy (MRS). What remains unclear is the extent to which these changes are a consequence of the emergence of psychotic disorders or the result of treatment with antipsychotic medication. We assessed 34 patients with first episode psychosis (15 antipsychotic naïve) and 19 age- and gender-matched controls using short-echo MRS in the medial temporal lobe bilaterally. Overall, there were no differences in any metabolite, regardless of treatment status. However, when the analysis was limited to patients with a diagnosis of schizophrenia, schizophreniform or schizoaffective disorder, significant elevations of creatine/phosphocreatine (Cr/PCr) and myo-inositol (mI) were found in the treated group. These data indicate a relative absence of temporal lobe metabolic abnormalities in first episode psychosis, but suggest that some treatment-related changes in mI might be apparent in patients with schizophrenia-spectrum diagnoses. Seemingly illness-related Cr/PCr elevations were also specific to the diagnosis of schizophrenia-spectrum disorder and seem worthy of future study.

The efficacy of an augmented virtual reality system to alleviate pain in children undergoing burns dressing changes : a randomised controlled trial

In children, the pain and anxiety associated with acute burn dressing changes can be severe, with drug treatment alone frequently proving to be inadequate. Virtual reality (VR) systems have been successfully trialled in limited numbers of adult and paediatric burn patients. Augmented reality (AR) differs from VR in that it overlays virtual images onto the physical world, instead of creating a complete virtual world. This prospective randomised controlled trial investigated the use of AR as an adjunct to analgesia and sedation in children with acute burns. Forty-two children (30 male and 12 female), with an age range of 3–14 years (median age 9 years) and a total burn surface area ranging from 1 to 16% were randomised into a treatment (AR) arm and a control (basic cognitive therapy) arm after administration of analgesia and/or sedation. Pain scores, pulse rates (PR), respiratory rates (RR) and oxygen saturations (SaO2) were recorded pre-procedurally, at 10 min intervals and post-procedurally. Parents were also asked to grade their child's overall pain score for the dressing change. Mean pain scores were significantly lower (p = 0.0060) in the AR group compared to the control group, as were parental pain assessment scores (p = 0.015). Respiratory and pulse rates showed significant changes over time within groups, however, these were not significantly different between the two study groups. Oxygen saturation did not differ significantly over time or between the two study groups. This trial shows that augmented reality is a useful adjunct to pharmacological analgesia.

Mrs Klein

Described as ‘ferociously sharp’, Crossbow Production’s Mrs Klein is about the formidable psychoanalyst Melanie Klein whose ruthlessly ‘objective’ case studies of her children won her acclaim as both an inspiring and appalling woman. Did her ‘study’ drive her son to suicide? Starring Therese Collie (La Boite), Louise Brehmer (QTC, La Boite) and Caroline Beck (New York Broadway credits). Directed by Dr Christian Heim. Live classical music and sharp wit combine to make this a memorable production.