Becker muscular dystrophy with marked divergence between clinical and molecular genetic findings: case series

Both Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are caused by mutations of the X-linked dystrophin gene. BMD patients are less affected clinically than DMD patients. We present five patients with a diagnosis of BMD. First, two identical twins, with a deletion of exon 48 of the dystrophin gene, who experienced prominent muscle cramps from the age of three. The histopathological examination of muscle biopsies of these two twins revealed only very slight muscle fiber alterations. Second, two brothers who displayed marked, unusual intrafamilial variability of the clinical picture as well as showing a new point mutation in the dystrophin gene. And finally, a fifth boy who displayed a new point mutation in the dystrophin gene. Although he was clinically asymptomatic at the age of 15 and muscle biopsy only showed very minor myopathic signs, serum Creatine Kinase (CK) levels had been considerably elevated for years. Taken together, these cases add to the spectrum of marked discrepancies in clinical, histopathological and molecular genetic findings in BMD.

Ferdinand Wilhelm Becker : eine Heldengestalt in d. Judenmission des 19. Jahrhunderts

von W. Becker

Ansprache an die vor der Abstimmung seiner Glaubensgenossen in der Communalschul-Angelegenheit in der Becker-schen Hütte versammelt gewesenen Bürger hiesiger Stadt

von Adolf Salvendi

Benno Becker

Karl Schwarz

Benno Becker [Illustration] : (Porträt)

Scan von Monochrom-Mikroform

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 575 - Übersendung an Johann August Becker seines Buches "Schopenhauer und seine Freunde"

u.a.: Umstände der Werkentstehung;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 965 - Mitteilung der Erwerbung des Briefwechsels von Arthur Schopenhauer mit Johann August Becker

u.a. Jean Paul; Johann Wolfgang von Goethe; Friedrich Schiller; Julius Frauenstädt; Pessimismus; Otto von Bismarck; Politik; Schopenhauer-Denkmal; Wille; Theorie; Philosophie; Publikationen zu Schopenhauer; Ethik; Materialismus;

Referat über "Die Coniferen zu Miechowitz, zusammengestellt von B. Becker, Garten-Inspector in Miechowitz"

Von J. Kramer

Albert Becker, Brustbild

Signatur des Originals: S 36/F00096

Karl Becker, Ganzfigurbildnis

Signatur des Originals: S 36/F00097

Georg Becker, Brustbild

Signatur des Originals: S 36/F00098