Œuvres posthumes d'André Chénier, augmentées d'une notice historique,

Mode of access: Internet.

Quelques traits de la vie privée de Frédéric-Guillaume II, roi de Prusse.

Mode of access: Internet.

Guillaume Tell; mélodrame en six parties.

Without music, tunes indicated by title.

Arnold, the American traitor; André, the British spy; Washington, the defender of constitutional liberty, the father of his country, the commander-in-chief of the American army.

Mode of access: Internet.

Tong ren ji : 12 juan /

Block print.

Data compilation on the biological response to ocean acidification: environmental and experimental context of data sets and related literature

The exponential growth of studies on the biological response to ocean acidification over the last few decades has generated a large amount of data. To facilitate data comparison, a data compilation hosted at the data publisher PANGAEA was initiated in 2008 and is updated on a regular basis (doi:10.1594/PANGAEA.149999). By January 2015, a total of 581 data sets (over 4 000 000 data points) from 539 papers had been archived. Here we present the developments of this data compilation five years since its first description by Nisumaa et al. (2010). Most of study sites from which data archived are still in the Northern Hemisphere and the number of archived data from studies from the Southern Hemisphere and polar oceans are still relatively low. Data from 60 studies that investigated the response of a mix of organisms or natural communities were all added after 2010, indicating a welcomed shift from the study of individual organisms to communities and ecosystems. The initial imbalance of considerably more data archived on calcification and primary production than on other processes has improved. There is also a clear tendency towards more data archived from multifactorial studies after 2010. For easier and more effective access to ocean acidification data, the ocean acidification community is strongly encouraged to contribute to the data archiving effort, and help develop standard vocabularies describing the variables and define best practices for archiving ocean acidification data.

Princesses et duchesses bibliophiles à la cour de René d'Anjou

De nombreuses dames de la cour d'Anjou ont exercé un mécénat littéraire et bibliophilique important à la cour d'Anjou. Parmi elles se trouvent Marie de Blois (v. 1340-1404), Yolande d'Aragon (1381-1442), Isabelle de Lorraine (v. 1400-1453), Jeanne de Laval (1433-1498) et Marie de Clèves (1426-1487). Le mécénat de ces femmes, parentes, épouses ou amies de René d'Anjou, est ici abordé à travers les documents d'archives et les manuscrits conservés qui attestent d'un intérêtréel et constant pour l'art du livre et de l'enluminure et pour la littérature en vogue à la cour. Une attention toute particulière est réservée au Pèlerinage de Vie humaine de Guillaume de Digulleville dont la version rimée, et plus tard la version en prose commandée par Jeanne de Laval, n'a cessé de captiver le lectorat féminin et notamment Marguerite d'Anjou, Blanche d'Anjou et Guyonne de Beauvau

FTO genotype is associated with phenotypic variability of body mass index

There is evidence across several species for genetic control of phenotypic variation of complex traits1, 2, 3, 4, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ~170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)5, 6, 7, is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ~0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation9, 10. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Development of a Multiplexed Bead-Based Suspension Array for the Detection and Discrimination of Pospiviroid Plant Pathogens

Efficient and reliable diagnostic tools for the routine indexing and certification of clean propagating material are essential for the management of pospiviroid diseases in horticultural crops. This study describes the development of a true multiplexed diagnostic method for the detection and identification of all nine currently recognized pospiviroid species in one assay using Luminex bead-based suspension array technology. In addition, a new data-driven, statistical method is presented for establishing thresholds for positivity for individual assays within multiplexed arrays. When applied to the multiplexed array data generated in this study, the new method was shown to have better control of false positives and false negative results than two other commonly used approaches for setting thresholds. The 11-plex Luminex MagPlex-TAG pospiviroid array described here has a unique hierarchical assay design, incorporating a near-universal assay in addition to nine species-specific assays, and a co-amplified plant internal control assay for quality assurance purposes. All assays of the multiplexed array were shown to be 100% specific, sensitive and reproducible. The multiplexed array described herein is robust, easy to use, displays unambiguous results and has strong potential for use in routine pospiviroid indexing to improve disease management strategies.

Graenum Berger papers, undated, (1825)-2002

Contains correspondence, minutes, reports, clippings, manuscripts, research materials, journal articles, photographs and publications; primarily relating to Berger's involvement with Ethiopian Jewry and his efforts to bring about their rescue through the organization he formed, the American Association for Ethiopian Jews. Also contains material from Berger's other interests- his writings, travels through the world and to Israel and Ethiopia, community affiliations, research in Black American Jews, profession as a Jewish social work executive, his commitment to Jewish causes and to Israel. There are also many personal and biographical materials from the numerous long-term friendships and associations he established.

Collecção das Leis do Imperio do Brazil de 1825

Parte 1 - Decretos, Cartas Imperiaes e Alvarás

Collecção dos breves pontificios, e leys regias, que forão expedidos, e publicadas desde o anno de 1741, sobre a liberdade das pessoas, bens, e commercio dos indios do Brasil : dos excessos que naquelle Estado obraram os regulares da companhia denominada de Jesu; das reprezentaçoens que Sua Magestade Fidelissima fez à Santa Séde Apostolica, sobre esta materia até a expedição do breve que ordenou a reforma dos sobreditos regulares

Brasil. [Leis etc]

Ibex-35 eta IGBM-ren eraginkortasunaren analisia

Artikulu honetan Markowitz-en eredua azaltzen da. Hasieratik Markowitz-en ereduak garrantzia handia izan du teorikoki, garapen eta eratorri ugari eraginez. Gainera, finantza aktiboen merkatuko oreka teoria desberdinen oinarria ere izan dela esan daiteke. Dena den, karteren kudeatzaile eta analisigileen artean praktikan duen erabileran ez da teorian izan duen adina arrakastatsua izan. Egindako ikerketa enpirikoan Markowitz-en ereduak merkatuko erreferentzia karterak (IBEX-35 eta IGBM) gainditzeko gai diren karterak ematen ditu alde batetik. Eta bestetik, IBEX-35 eta IGBM ez dira kartera eraginkorrak eta ez dute merkatuko kartera teorikoaren portaera islatzen.

Kazetaritza infografiaren garapena espainiako prentsan. "El Correo Español-El Pueblo Vasco"-ren kasua

383 p. : il.; gráf.